Category: 1060815-90-8

Reference of 1060815-90-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1060815-90-8, name is 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3ClIN3, molecular weight is 279.47, as common compound, the synthetic route is as follows.

Methyl 2-bromo-2-methylpropanoate (663 mL, 5.13 mmol) was added to 2-chloro-5- iodo-7H-pyrrolo[2,3-c/]pyrimidine (Preparation 74, 358.1 g, 1 .28 mol), potassium iodide (21 .3 g, 128 mmol) and cesium carbonate (1670 g, 5.13 mol) in DMF (7162 mL). The mixture was heated at 60C for 19 hours. The reaction mixture was diluted with water (7000 mL) and stirred at room temperature for 42 hours. The mixture was filtered and the solid was washed with water (500 mL) to afford the title compound as a beige solid in 92% yield, 445.8 g. 1H NMR (400 MHz, CDCl3): delta ppm 1.89 (s, 6H), 3.65 (s, 3H), 7.39 (s, 1 H), 8.56 (s, 1 H)

Statistics shows that 1060815-90-8 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; PFIZER LIMITED; ANDREWS, Mark, David; BAGAL, Sharanjeet, Kaur; BROWN, David, Graham; GIBSON, Karl, Richard; OMOTO, Kiyoyuki; RYCKMANS, Thomas; SABNIS, Yogesh; SKERRATT, Sarah, Elizabeth; STUPPLE, Paul, Anthony; WO2014/53967; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1060815-90-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1060815-90-8, name is 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3ClIN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

-lodopropane (2.1 mL, 19.68 mmol) was added to a mixture of 2-chloro-5-iodo-7H- pyrrolo[2,3-d]pyrimidine (5.50 g, 19.8 mmol) and cesium carbonate (19.18 g, 59.04 mmol) in DMF (30 mL). The mixture was stirred at room temperature for 3 hours. The reaction mixture was diluted with EtOAc, washed with water, brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 10% EtOAc in hexane to afford the title compound as a white solid (5.5 g, 87%). 1H NMR (400 MHz, CDCl3): delta ppm 1.50 (d, 6H), 5.10 (m, 1 H), 7.36 (s, 1 H), 8.55 (s, 1 H). LCMS (System 10) Rt = 3.6 minutes MS m/z 322 [M+H]+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060815-90-8, 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; PFIZER LIMITED; ANDREWS, Mark, David; BAGAL, Sharanjeet, Kaur; BROWN, David, Graham; GIBSON, Karl, Richard; OMOTO, Kiyoyuki; RYCKMANS, Thomas; SABNIS, Yogesh; SKERRATT, Sarah, Elizabeth; STUPPLE, Paul, Anthony; WO2014/53967; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1060815-90-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1060815-90-8, name is 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3ClIN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A.21 (400 mg, 1.43 mmol), benzenesulphonyl chloride (272 muL, 2.13 mmol), DMAP (18 mg, 0.15 mmol) and Hnig base (350 muL, 2.17 mmol) are taken up in 10 mL DCM and stirred for 16 h at 200C. The solvent is eliminated in vacuo, the residue is purified by column chromatography (method prep. HPLC2; 10 % acetonitrile to 95 % in 12 min) and A.21-PG (HPLC-MS: tRet. = 1.98 min; MS(M+H)+ = 420; method FEC3) is obtained.

According to the analysis of related databases, 1060815-90-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; McCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7114; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1060815-90-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1060815-90-8, name is 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

A.21 (400 mg, 1.43 mmol), benzenesulphonyl chloride (272 muL, 2.13 mmol), DMAP (18 mg, 0.15 mmol) and Hnig base (350 muL, 2.17 mmol) are taken up in 10 mL DCM and stirred for 16 h at 200C. The solvent is eliminated in vacuo, the residue is purified by column chromatography (method prep. HPLC2; 10 % acetonitrile to 95 % in 12 min) and A.21-PG (HPLC-MS: tRet. = 1.98 min; MS(M+H)+ = 420; method FEC3) is obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060815-90-8, 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; MCCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7116; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia