Category: 106157-82-8

Related Products of 106157-82-8 ,Some common heterocyclic compound, 106157-82-8, molecular formula is C6H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 11a: 1 -(2-aminopyrimidin-4-yl)ethanone oxime; To a suspension of 1 -(2-aminopyrimidin-4-yl)ethanone (3a) (4 g) in ethanol (70 mL) and water (14 mL) was added hydroxylamine hydrochloride (4.05 g) followed by sodium acetate (7.18 g) and the mixture was stirred at room temperature for one hour. After this time the reaction mixture was concentrated in vacuo, water was added and stirred for 15 minutes. The precipitate was collected by filtration and washed with water and dried in vacuo at 40C overnight to afford the title product (4.29 g) as a light yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 106157-82-8, 1-(2-Aminopyrimidin-4-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; N.V. Organon; GROVE, Simon James Anthony; MORRISON, Angus John; JAMIESON, Craig; PALIN, Ronald; MACLEAN, John Kinnaird Ferguson; WO2011/76723; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106157-82-8, name is 1-(2-Aminopyrimidin-4-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1-(2-Aminopyrimidin-4-yl)ethanone

Step C: Preparation of tert-Butyl [7- {2- [L- (2-AMINO-] [PYRIMIDIN-4-YL)-ETHYLAMINO]-BENZOYLAMINO}-4,] 4-dimethyl-3,4- [DIHYDRO-LH-ISOQUINOLINE-2-CARBOXYLATE] To a solution of [1-(2-AMINO-PYRIMIDIN-4-YL)-ETHANONE] (Step B, 200 mg, 1.46 mmol) in toluene (15 mL) was added, 7- [(2-AMINO-BENZOYLAMINO)-4,] 4-dimethyl-3, [4-DIHYDRO-LH-] isoquinoline-2-carboxylic acid tert-butyl ester (Example 15, Step A) (288 mg, 0.73 mmol), and HOAc (3 drops). The resulting mixture was heated at [95 C] under N2 for 20 h. The reaction was cooled to RT and NaBH (OAc) 3 (620 mg, 2.92 mmol) was added and reheated for 3 h. The reaction was cooled to RT, quenched with [NA2CO3] solution (2 M, 5 mL), solvent was evaporated in vacuo. The residue was extracted with CHC13. The organic layer was washed with saturated [NAHC03,] water, brine, dried over [MGS04,] and evaporated in vacuo. The crude solid was purified by chromatography on silica gel. Elution with [CH2CL2 : MEOH] (95: 5) gave THE final compound. MS [M/Z] : 517.3 (M+H). [CALC’D.] for [C2GH37N603-] 517.63.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106157-82-8, 1-(2-Aminopyrimidin-4-yl)ethanone.

Reference:
Patent; AMGEN INC.; WO2004/5279; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 106157-82-8, Adding some certain compound to certain chemical reactions, such as: 106157-82-8, name is 1-(2-Aminopyrimidin-4-yl)ethanone,molecular formula is C6H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106157-82-8.

Example 2 1- (2-AMINOPYRIMIDIN-4-YL)-2-BROMOETHANONE hydrobromide The title compound (a) was prepared by working as described in J. Het. Chem. 1985,22, 1723. A mixture of 3,3-dimethoxy-2-butanone (25 9, 189.16 MMOL) and N, N-DIMETHYLFORMAMIDE DIMETHYLACETAL (22.5 g, 189.16 MMOL) were stirred at 110C for 30 hours and then distilled (115C, 1 mmHg) thus obtaining 1-(DIMETHYLAMINO)-4, 4-DIMETHOXYPENT-1-EN-3-ONE, as a yellow solid (27.3 G, 146 mmol, 77%). Onto a solution of sodium (3.48 g, 151.67 MMOL) in anhydrous ethanol (400 mL), solid guanidine hydrochloride (14.5 G, 151.67 MMOL) was added at r. t. , to give a white suspension into which a solution of 1-(DIMETHYLAMINO)-4, 4-DIMETHOXYPENT-1-EN-3-ONE (28.4 g, 151.67 MMOL) in anhydrous ethanol (50 mL) was added. The mixture was refluxed for 19 hours. After cooling, the precipitate was filtered and washed with ethanol and with plenty of water, thus obtaining a white solid (8.56 G). The ethanolic solutions were concentrated to dryness, taken up with boiling ethyl acetate (1000 mL), filtered while hot and then cooled to yield a second crop. Total amount of 4- (1, 1-DIMETHOXYETHYL) PYRIMIDIN-2-AMINE : 17.66 G, 63. 5%. A solution of the said amine (17. 5 G, 95.5 MMOL) in formic acid was stirred at r. t. for 6 hours and concentrated to dryness and the residue was stirred in ethanol (50 mL) and then filtered thus obtaining 1- (2-aminopyrimidin-4-yl) ethanone (9.2 g, 70%). To a solution of 1- (2- aminopyrimidin-4-yl) ethanone (412 mg, 3 MMOL) in glacial acetic acid (1 mL) and 48% aq. HBr (0.3 mL), bromine (0.153 mL) in acetic acid (0.4 mL) was added and the resulting orange solution was stirred at r. t. for 15 hours. After diluting with ethyl acetate (15 mL) the precipitate was filtered and washed with ethyl acetate thus affording the title compound as a whitish solid (580 mg, 65%).

According to the analysis of related databases, 106157-82-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PHARMACIA & ITALIA S.p.A.; WO2005/14572; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia