Category: 108-52-1

Analyzing the synthesis route of 4-Methylpyrimidin-2-amine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-52-1, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 108-52-1, 4-Methylpyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-52-1, blongs to pyrimidines compound. SDS of cas: 108-52-1

Step 44a: 5-Bromo-4-methylpyrimidin-2-amine (Compound 0601-125)[0378]A mixture of 2-amino-4-methylpyrimidine (4.0 g, 36.7 mmol), NBS (7.18 g, 40.3 mmol) in chloroform (100 mL) was stirred for 2 h at room temperature, then the solvent was removed in vacuum. Water (100 mL) was added and stirred for 30 min at room temperature, filtered. The solid was washed with water and dried to get compound 0601-125 (6.3 g, 91percent) as a white solid. LCMS: 188 [M+1]+, 1H NMR (400 MHz, DMSO-d6) delta 2.32 (s, 3H), 6.79 (s, 2H), 8.21 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-52-1, its application will become more common.

Reference:
Patent; Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng; US2013/102595; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The origin of a common compound about 108-52-1

Statistics shows that 108-52-1 is playing an increasingly important role. we look forward to future research findings about 4-Methylpyrimidin-2-amine.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 108-52-1, name is 4-Methylpyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. 108-52-1

[0242] To a solution of 4-methylpyrimidine-2-ylamine (10.9 g, lOO mmol) in chloroform (400 mL) was added N-bromosuccinimide (17.8 g, 100 mmol). The solution was stirred in the dark for 15 hours, at which time it was added to CH2Cl2 (140O mL), washed with IN NaOH (3×200 mL) and NaCl(sat.) (100 mL), dried over Na2SO4, filtered and concentrated, yielding 5-bromo-4-methylpyrimidine-2-ylamine (18.8 g, 99percent). LCMS (m/z): 188.0/190.0 (MH+). 1H NMR (CDCl3): delta 8.22 (s, IH), 5.02 (bs, 2H), 2.44 (s, 3H).

Statistics shows that 108-52-1 is playing an increasingly important role. we look forward to future research findings about 4-Methylpyrimidin-2-amine.

Reference:
Patent; NOVARTIS AG; WO2007/84786; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia