Category: 108-79-2

Adding a certain compound to certain chemical reactions, such as: 108-79-2, 4,6-Dimethylpyrimidin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-79-2, blongs to pyrimidines compound. category: pyrimidines

Phosphoric trichloride was added to 4,6-dimethylpyrimidin-2-ol at 0 C. and was heated at 110 C. for 16 h. The solvent was evaporated from the reaction mixture. The reaction was quenched with ice cold water and extracted with ethyl acetate. The combined organic layer was dried with sodium sulphate and evaporated under reduced pressure to obtain 2-chloro-4,6-dimethylpyrimidine.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-79-2, its application will become more common.

Reference:
Patent; LANDOS BIOPHARMA, INC.; Bassaganya-Riera, Josep; Leber, Andrew; Hontecillas, Raquel; (43 pag.)US10487057; (2019); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

108-79-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108-79-2, name is 4,6-Dimethylpyrimidin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

Example 246 Methyl-phenyl-carbamic Acid 4,6-dimethyl-pyrimidin-2-yl Ester A solution of 4,6-dimethyl-2-hydroxypyrimidine (0.37 g, 3.00 mmol)), 1-methyl-3-(methyl-phenyl-carbamoyl)-3H-imidazol-1-ium iodide (1.03 g, 3.00 mmol) and triethylamine (0.42 ml, 3.00 mmol) in acetonitrile (15 ml) was stirred at room temperature for 18 hours. The solvent was evaporated in vacuo and the residue was purified by flash column chromatography (SiO2, ethyl acetate:heptane (50:50)) yielding the title compound (0.46 g, 60% yield) as a white solid. 1H NMR (300 MHz, CDCl3): delta 2.48 (s, 6H), 3.43 (br.s, 3H), 6.92 (br.s, 1H), 7.22 (m, 1H), 7.37 (m, 4H); HPLC-MS (Method A): m/z=258 (M+H); Rt=2.77 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 108-79-2, 4,6-Dimethylpyrimidin-2(1H)-one.

Reference:
Patent; Ebdrup, Soren; de Jong, Johannes Cornelis; Jacobsen, Poul; Hansen, Holger Claus; Vedso, Per; US2003/166644; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia