Category: 108381-23-3

Adding a certain compound to certain chemical reactions, such as: 108381-23-3, Ethyl 2-chloro-4,6-dimethylpyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Ethyl 2-chloro-4,6-dimethylpyrimidine-5-carboxylate, blongs to pyrimidines compound. Safety of Ethyl 2-chloro-4,6-dimethylpyrimidine-5-carboxylate

General procedure: To a solution of appropriate 10 (0.5 g, 2.56 mmol) in dry CH3CN (30 ml), dry K2CO3 (1.06 g, 7.69 mmol) and propargyl alcohol (0.2 ml, 3.84 mmol) were added in that sequence and reaction mixture was refluxed overnight. After completion of reaction (TLC), CH3CN was removed under vacuum. Water was then added to the residue and the product extracted with DCM (2 x 20 ml). Solvent was removed to obtain crude 11, which was purified by column chromatography over silica 60-120 using 20:80 (ethyl acetate/hexane) as eluent to isolate analytically pure 11a-f.

The synthetic route of 108381-23-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chopra, Rakesh; De Kock, Carmen; Smith, Peter; Chibale, Kelly; Singh, Kamaljit; European Journal of Medicinal Chemistry; vol. 100; 1; (2015); p. 1 – 9;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 108381-23-3 ,Some common heterocyclic compound, 108381-23-3, molecular formula is C9H11ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 2-amino-6-methoxy-l,2,3,4-tetrahydro-naphthalene hydrochloride (87mg, 0.43mmol), 2-chloro-4,6-dimethyl-pyrimidine-5-carboxylic acid ethyl ester (71mg, O.33mmol) and KOAc (150mg, 1.5mmol) in ethanol (3ml) was microwaved at 120 C for lh. The reaction mixture was cooled to rt, quenched with 1NHC1 and extracted with EtOAc. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated. The crude residue was purified by flash chromatography with a 5-60% EtOAC in hexane gradient to afford the desired product (69mg, 60% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108381-23-3, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GILLESPIE, Paul; MICHOUD, Christophe; RUPERT, Kenneth Carey; THAKKAR, Kshitij Chhabilbhai; YI, Lin; WO2012/123467; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 108381-23-3, name is Ethyl 2-chloro-4,6-dimethylpyrimidine-5-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Ethyl 2-chloro-4,6-dimethylpyrimidine-5-carboxylate

Step 3. Synthesis of ethyl 2-(3,4-dihydroisoquinolin-2(1H)-yl)-4,6-dimethylpyrimidine-5-carboxylate, 6c 1,8-diazabicyclo[5.4.0]undec-7-ene (1.086 g, 7.15 mmol) was added to a mixture of 6b (1.02 g, 4.75 mmol) and 1,2,3,4-tetrahydroisoquinoline (0.95 g, 7.13 mmol) in DMSO (5 ml) at 0 C. over 5 minutes. The mixture was stirred for an additional 5 minutes at room temperature. The mixture was washed with brine, extracted with ethyl acetate and chromatographed to yield 6c (1.43 g, 4.5 mmol, 95%).

With the rapid development of chemical substances, we look forward to future research findings about 108381-23-3.

Reference:
Patent; VALEANT PHARMACEUTICALS INTERNATIONAL; US2008/318979; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia