Reference of 1086382-38-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1086382-38-8, name is 4-Bromo-6-hydroxypyrimidine, molecular formula is C4H3BrN2O, molecular weight is 174.98, as common compound, the synthetic route is as follows.
Step A: 6-Bromo-3-methylpyrimidin-4(3H)-one To a solution 6-bromopyrimidin-4(3H)-one (696 mg, 2.0 mmol) in DMF (3.0 mL) was added K2CO3 (828 mg, 6.0 mmol), CH3I (568 mg, 4.0 mmol), the reaction mixture was stirred at 50 C for 30 minutes. The mixture was cooled to ambient temperature, diluted with EtOAc (20 mL), washed with sodium bicarbonate (10 mL) and brine (10 mL), dried over MgS04, filtered and concentrated. The residue was purified with silica gel column (Petroleum ether : ethyl acetate = 1 : 1) to obtaine product: LC/MS m/z = 189.01 (M+H) +.
The chemical industry reduces the impact on the environment during synthesis 1086382-38-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MCCOMAS, Casey, C.; KUDUK, Scott, D.; REGER, Thomas, S.; WO2014/81617; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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