Category: 109-12-6

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Application In Synthesis of 109-12-6.

Huang, Ronghui;Zhao, Weijia;Xu, Shengwen;Xu, Jingkai;Li, Chunxiao;Lu, Changsheng;Yan, Hong research published ã€?Photoredox B-H functionalization to selective B-N(sp³) coupling of nido-carborane with primary and secondary aminesã€? the research content is summarized as follows. Access to nido-carborane site-selective B-N(sp³) coupling by photoredox catalyzed B-H activation has been achieved for the first time, which leads to the synthesis of a series of nitrogen-containing nido-carboranes with moderate to good yields. This protocol is applicable to primary and secondary amines containing alkyl, or heteroaryl groups as well as sulfonamides. Furthermore, the open to air and metal-free conditions with excellent site-selectivity represent a significant improvement for B-H functionalization of nido-carboranes with organic functionalities.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Application In Synthesis of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. SDS of cas: 109-12-6.

Ignatovich, Zhanna;Novik, Khristina;Abakshonok, Anna;Koroleva, Elena;Beklemisheva, Anna;Panina, Larisa;Kaniukov, Egor;Anisovich, Marina;Shumskaya, Alena research published ã€?One-step synthesis of magnetic nanocomposite with embedded biologically active substanceã€? the research content is summarized as follows. Magnetic nanocomposites based on hydroxyapatite were prepared by a one-step process using the hydrothermal coprecipitation method to sinter iron oxides (Fe3O4 and γ-Fe2O3). The possibility of expanding the proposed technique for the synthesis of magnetic composite with embedded biol. active substance (BAS) of the 2-arylaminopyrimidine group was shown. The composition, morphol., structural features, and magnetic characteristics of the nanocomposites synthesized with and without BAS were studied. The introduction of BAS into the composite synthesis resulted in minor changes in the structural and phys. properties. The specificity of the chem. bonds between BAS and the hydroxyapatite-magnetite core was revealed. The kinetics of the BAS release in a solution simulating the stomach environment was studied. The cytotoxicity of (HAP)FexOy and (HAP)FexOy + BAS composites was studied in vitro using the primary culture of human liver carcinoma cells HepG2. The synthesized magnetic composites with BAS have a high potential for use in the biomedical field, for example, as carriers for magnetically controlled drug delivery and materials for bone tissue engineering.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., SDS of cas: 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Recommanded Product: Pyrimidin-2-amine.

Iwamori, Ryota;Sato, Ryota;Kuwabara, Junpei;Yasuda, Takeshi;Kanbara, Takaki research published �Synthesis of Pyrrole-Based Poly(arylenevinylene)s via Co-Catalyzed Hydroarylation of Alkynes� the research content is summarized as follows. Polyaddition via the Co-catalyzed hydroarylation of 1-(2-pyrimidinyl)pyrrole with aromatic diynes affords poly(arylenevinylene)s under mild conditions. This reaction avoids production of stoichiometric amounts of byproducts. Although structural anal. of the obtained polymers reveals the presence of 1,1-vinylidene unit, switching the counter anion of the Co catalyst and steric hindrance of the diyne monomers improves the regioselectivity of the polymers. When a catalyst with bulky counter anions is used for the reaction of less hindered diyne monomers, 1,2-vinylene linkages are formed dominantly over 1,1-vinylidene linkages (93:7). The effect of the regioselectivity of the polymer on the optical and semiconducting properties is also evaluated.

Recommanded Product: Pyrimidin-2-amine, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Synthetic Route of 109-12-6.

Jadhav, Mrunal;Sankhe, Kaksha;Bhandare, Richie R.;Edis, Zehra;Bloukh, Samir Haj;Khan, Tabassum Asif research published �Synthetic Strategies of Pyrimidine-Based Scaffolds as Aurora Kinase and Polo-like Kinase Inhibitors� the research content is summarized as follows. A review. Small mols. containing heterocyclic moieties have attracted considerable interest for designing new antitumor agents. Of these, the pyrimidine ring system is found in multitude of drug structures, and being the building unit of DNA and RNA makes it an attractive scaffold for the design and development of anticancer drugs. Currently, 22 pyrimidine-containing entities are approved for clin. use as anticancer drugs by the FDA. An exhaustive literature search indicates several publications and more than 59 patents from the year 2009 onwards on pyrimidine derivatives exhibiting potent antiproliferative activity. These pyrimidine derivatives exert their activity via diverse mechanisms, one of them being inhibition of protein kinases. Aurora kinase (AURK) and polo-like kinase (PLK) are protein kinases involved in the regulation of the cell cycle. Within the numerous pyrimidine-based small mols. developed as anticancer agents, this review focuses on the pyrimidine fused heterocyclic compounds modulating the AURK and PLK proteins in different phases of clin. trials as anticancer agents. This article aims to provide a comprehensive overview of synthetic strategies for the preparation of pyrimidine derivatives and their associated biol. activity on AURK/PLK. It will also present an overview of the synthesis of the heterocyclic-2-aminopyrimidine, 4-aminopyrimidine and 2,4-diaminopyrimidine scaffolds, and one of the pharmacophores in AURK/PLK inhibitors is described systematically.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Synthetic Route of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Related Products of 109-12-6.

Jati, Ayan;Dey, Kaushik;Nurhuda, Maryam;Addicoat, Matthew A.;Banerjee, Rahul;Maji, Biplab research published ã€?Dual Metalation in a Two-Dimensional Covalent Organic Framework for Photocatalytic C-N Cross-Coupling Reactionsã€? the research content is summarized as follows. Herein, a dual metalation strategy in a single two-dimensional-COF TpBpy for performing a variety of C-N cross-coupling reactions. [Ir(ppy)₂(CH₃CN)₂]PF₆ [ppy = 2-phenylpyridine], containing two labile CH₃CN groups, and NiCl₂ were used as iridium and nickel-metal precursors, resp., for postsynthetic decoration of the TpBpy COF was reported. Moving from the traditional approach, the COF-backbone host for visible-light-mediated nickel-catalyzed C-N coupling reactions was focused. The controlled metalation and recyclability without deactivation of both catalytic centers were unique with respect to previously reported coupling strategies. Various photoluminescence, electrochem., kinetic, and Hammett correlation studies to understand the salient features of the catalyst and reaction mechanism was performed. Furthermore, theor. calculations delineated the feasibility of electron transfer from the Ir center to the Ni center inside the confined pore of the TpBpy COF. The dual metal anchoring within the COF backbone prevented nickel-black formation. The developed protocol enables selective and reproducible coupling of a diverse range of amines (aryl, heteroaryl, and alkyl), carbamides, and sulfonamides with electron-rich, neutral, and poor (hetero) aryl iodides up to 94% isolated yield. The reaction was also be performed on a gram scale. Furthermore, to establish the practical implementation of this approach, was applied the on synthetic strategy for the late-stage diversification of the derivatives of ibuprofen, naproxen, gemfibrozil, helional, and amino acids. The methodol. could also be applied to synthesize pharmacophore N,5-diphenyloxazol-2-amine and Food and Drug Administration-approved drugs, including flufenamic acid, flibanserin, and tripelennamine.

Related Products of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Application In Synthesis of 109-12-6.

Guan, Shengjie;Wu, Fan;Wu, Qian;He, Zhichao;Jiang, Jing;Huang, Yudong;Liu, Li research published 《 Modification of silicone resins by Si-N cross-dehydrocoupling with perfect thermal stability and mechanical performance》, the research content is summarized as follows. A series of new types of modified hydrosilanes were synthesized, using hydrosilanes and nitrogen heterocycles (triethoxysilane, 2-aminopyrimidine, 1,2,4-triazin-3-amine, benzylamine and 2-aminobenzothiazole), by Si-N cross-dehydrocoupling catalyzed by Ru₃CO₁₂. The results of the synthesis were then demonstrated by ¹H NMR and GPC testing. Furthermore, modified silicone resins were obtained by a hydrolytic condensation reaction catalyzed by tetramethylammonium hydroxide and characterized by TGA, DSC and FT-IR. Next, excellent thermal stabilities were determined (best initial decomposition temperature was approx. 400°C, T95% was 595°C, the mass residue rate at 800°C was 87.2%). Carbon fiber reinforced silicone matrix composites were manufactured according to the tech. process developed using DSC and rotary viscometer test results, and the mech. property (ILSS) showed great improvement from 34.8 to 45.8 MPa because of the modification of Si-N cross-dehydrocoupling. After pyrolysis up to 1000°C, the composites still showed a superior ILSS value (19.6 MPa) and the modified silicone resins had a more regular and rounded microstructure and appeared to have ceramic-like particles of Si3N4. This work indicated that the silicone resin (Si-N) modified by cross-dehydrocoupling had greater competitiveness in the field of resin matrix composites.

Application In Synthesis of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Computed Properties of 109-12-6.

Guchhait, Sankar K.;Saini, Meenu;Khivsara, Viren J.;Giri, Santosh K. research published 《 Annulation of Conjugated Azine-Imine with a Sulfoxonium Ylide in a Noncarbenoid Route to Synthesize Multisubstituted Imidazole-Fused Heterocycles》, the research content is summarized as follows. A new [4+1]-annulation of in situ generated heterocyclic azine-aldimines with β-keto sulfoxonium ylides has been developed. The reaction constructs N-fused imidazole rings I (X=Y= CH,N; Ar¹= 4-ClC₆H₄, 4-BrC₆H₄, 4-CNC₆H₄, etc.; Ar² = 4-ClC₆H₄, 4-MeOC₆H₄, 4-FC₆H₄, etc.). In the reaction, the ylides play a dual-functional role of a nucleophilic 1,1-dipolar one-carbon synthon and a source of an internal oxidant, DMSO, that promotes in situ dehydrogenation to product scaffolds. The method enables access to imidazo-pyridine, pyrazine, and pyrimidine heteroaromatics

Computed Properties of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Synthetic Route of 109-12-6.

Guo, Ming;Zuo, Daiying;Zhao, Tianming;Li, Xiangyu;Cao, Jianshuang;Qiu, Yuxuan;Wei, Shangfei;Zhai, Xin research published 《 Structure-based optimization identified novel furyl-containing 2,4-diarylaminopyrimidine analogues as ALK/ROS1 dual inhibitors with anti-mutation effects》, the research content is summarized as follows. Aiming to develop ALK/ROS1 dual inhibitors overcoming ceritinib-resistant G1202R mutant, a dedicated structure-guided modification campaign was conducted based on ALK co-crystal structures. Twenty eight diarylaminopyrimidine (DAAP) analogs I [R = methanesulfonyl, acetyl; R¹ = furan-2-yl, oxolan-2-yl, (furan-2-ylmethyl)dimethylamine, etc.; X = O, NH, SO₂] possessing furan or THF group were designed and synthesized, among which compound I [R = methanesulfonyl, R¹ = (furan-2-ylmethyl)dimethylamine, X = S] bearing ((((dimethylamino)methyl)furan-2-yl)methyl)thio fragment was identified. Compound I [R = methanesulfonyl, R¹ = (furan-2-ylmethyl)dimethylamine, X = S] exhibited significant cytotoxicity on ALK-pos. Karpas299 and H2228 cells with IC₅₀ values of 20 nM and 110 nM. Meanwhile, compound I [R = methanesulfonyl, R¹ = (furan-2-ylmethyl)dimethylamine, X = S] turned out as the most potent entity superior to ceritinib with IC₅₀ values of 2.8, 2.6, 3.8 and 2.3 nM against ALKWT, ALKL1196M, ALKG1202R and ROS1WT, resp. Subsequently, western blot assay showed that compound I [R = methanesulfonyl, R¹ = (furan-2-ylmethyl)dimethylamine, X = S] significantly suppressed ALK and its downstream protein expression in a dose-dependent manner. Alternatively, the Hoechst 33258 and AO/EB staining assays illustrated that compound I [R = methanesulfonyl, R¹ = (furan-2-ylmethyl)dimethylamine, X = S] could induce H2228 cell apoptosis. Ultimately, the binding models of compound I [R = methanesulfonyl, R¹ = (furan-2-ylmethyl)dimethylamine, X = S] with ALKWT, ALKG1202R as well as ROS1 clearly presented the essential interactions within the active site. Together, compound I [R = methanesulfonyl, R¹ = (furan-2-ylmethyl)dimethylamine, X = S] was validated as a promising ALK/ROS1 dual inhibitor for ALKG1202R mutation correlated tumors.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Synthetic Route of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). COA of Formula: C4H5N3.

Haghbeen, Faheimeh;Ghorbanian, Nargess;Hajatpour, Golnaz;Amirzakaria, Javad Zamani;Eshghi, Hossein;Haghbeen, Kamahldin research published 《 Introducing a potential lead structure for the synthesis of more specific inhibitors of tyrosinases and catechol oxidases》, the research content is summarized as follows. Based on tyrosinase inhibition science, two pyrimidine derivatives were designed and studied. Docking of 2-dibenzylamine-5-hydroxy pyrimidine (dba5HP) and 2-benzylamino-5-hydroxy pyrimidine (ba5HP) on mushroom tyrosinase (MT) showed that the former could not occupy MT active site pocket, while ba5HP could do so (Moldock score = – 63.95). MD simulation revealed that the complex of ba5HP-MT reached stability < 30 ns. In silico biocompatibility examinations predicted high permeability, good bioavailability, low toxicity, and synthetic accessibility of 1.59 for ba5HP with high probability for CYP-mediated metabolism Subsequently, both compounds were synthesized in good yields. Kinetics studies proved that, unlike dba5HP, ba5HP could strongly inhibit MT competitively (IC₅₀ = 32.28, K_i = 11.32μM). Considering the facile synthesis, potential for structural modifications, and passing most of the lead-likeness filters, it seems likely that ba5HP plays key roles in the syntheses of novel depigmentation medicines as well as more specific inhibitors for various tyrosinases and polyphenol oxidases.

COA of Formula: C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Name: Pyrimidin-2-amine.

Ham, Won Seok;Choi, Hoonchul;Zhang, Jianbo;Kim, Dongwook;Chang, Sukbok research published 《 C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic Functionalization》, the research content is summarized as follows. A synthetic platform for site-selective C-H functionalization that affords pyrimidinyl iminium salt intermediates, which then can be transformed into various amine products I (R = azanyl, 5-(trifluoromethyl)-1,2,3,4-tetrahydropyridin-1-yl, methylaminyl, etc.; R¹ = H, Ph) in situ. was described. Mechanism-based reagent design allowed for the C2-selective amination of pyrimidines II, opening the new scope of site-selective heteroaryl C-H functionalization. This method is compatible with a broad range of pyrimidines II with sensitive functional groups, and can access complex aminopyrimidines I in high selectivity.

Name: Pyrimidin-2-amine, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia