Category: 109-12-6

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. HPLC of Formula: 109-12-6.

Fu, Zhequan;Lin, Qingyu;Xu, Zhan;Zhao, Yanzhao;Cheng, Yuan;Shi, Dai;Fu, Wenhui;Yang, Tingting;Shi, Hongcheng;Cheng, Dengfeng research published 《 P2X7 receptor-specific radioligand ¹⁸F-FTTM for atherosclerotic plaque PET imaging》, the research content is summarized as follows. P2X7 receptors have been considered as a promising biomarker for vulnerable atherosclerotic plaques, which are highly expressed by that instability-associated factors such as macrophages. Thus, we aim to investigate the feasibility of using specific P2X7-targeted 18F-labeled tracer 18F-FTTM ((2-chloro-3-[18F]fluorophenyl)[1,4,6,7-tetrahydro-1-(2-pyrimidinyl)-5H-1,2,3-triazolo[4,5-c]pyridin-5-yl]methanone) for PET study of vulnerable atherosclerotic plaques identification. The radioligand 18F-FTTM was achieved based on the copper-mediated radiofluorination of arylstannane. In vitro and in vivo experiments were performed to verify the biochem. properties. Dynamic 18F-FTTM Micro-PET/CT imaging was performed for 1 h on ApoE-/- mice (10, 20, 30 wk on high-fat diet) and wild-type C57BL/6 J mice on normal diet. Ex vivo PET imaging was conducted to verify the specificity of the radioligand. Serum inflammatory cytokines, lipids, and lipoproteins profiles were detected by ELISA. The lipid distribution and morphol. of plaques were evaluated by Oil Red O, HE, Masson, and immunofluorescence stainings. 18F-FTTM was afforded with decay-corrected radiochem. yields of 5-10%, specific activity of 269-320 MBq/nmol (n = 8, EOS), and radiochem. purity of above 99%. 18F-FTTM showed excellent stability in vitro, rapid blood clearance in mice, good affinity to RAW264.7 cells. We observed an increase in both in vivo and ex vivo imagings as disease progressed, and the imaging signatures correlated with histopathol. features. Furthermore, compared with 18F-FDG imaging, the SUVmax values of 18F-FTTM at the aortic arch of ApoE-/- mice of high-fat feeding for 20 and 30 wk were 43% and 53% higher than those of the control group, resp. We innovatively apply a new type P2X7-targeted PET probe (18F-FTTM) to identify vulnerable atherosclerotic plaques, to detect the inflammatory response of atherosclerosis, and to provide a powerful non-invasive method for the diagnosis of atherosclerotic lesions and new drug screening for accurate treatment.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., HPLC of Formula: 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Application In Synthesis of 109-12-6.

Gao, Kai;Shaabani, Shabnam;Xu, Ruixue;Zarganes-Tzitzikas, Tryfon;Gao, Li;Ahmadianmoghaddam, Maryam;Groves, Matthew R.;Doemling, Alexander research published 《 Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers》, the research content is summarized as follows. Hit finding in early drug discovery is often based on high throughput screening (HTS) of existing and historical compound libraries, which can limit chem. diversity, is time-consuming, very costly, and environmentally not sustainable. On-the-fly compound synthesis and in situ screening in a highly miniaturized and automated format has the potential to greatly reduce the medicinal chem. environmental footprint. Here, acoustic dispensing technol. has been used to synthesize a library in a 1536 well format based on the Groebke-Blackburn-Bienayme’ reaction (GBB-3CR) on a nanomole scale. The unpurified library was screened by differential scanning fluorimetry (DSF) and cross-validated using microscale thermophoresis (MST) against the oncogenic protein-protein interaction menin-MLL. Several GBB reaction products were found as μM menin binder, and the structural basis of the interactions with menin was elucidated by co-crystal structure anal. Miniaturization and automation of the organic synthesis and screening process can lead to an acceleration in the early drug discovery process, which is an alternative to classical HTS and a step towards the paradigm of continuous manufacturing

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Application In Synthesis of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Application In Synthesis of 109-12-6.

Djud, Mateja;Tichotova, Marketa;Prochazkova, Eliska;Baszczynski, Ondrej research published 《 Phosphate-Based Self-Immolative Linkers for the Delivery of Amine-Containing Drugs》, the research content is summarized as follows. Amine-containing drugs often show poor pharmacol. properties, but these disadvantages can be overcome by using a prodrug approach involving self-immolative linkers. Accordingly, we designed l-lactate linkers as ideal candidates for amine delivery. Furthermore, we designed linkers bearing two different cargos (aniline and phenol) for preferential amine cargo release within 15 min. Since the linkers carrying secondary amine cargo showed high stability at physiol. pH, we used our strategy to prepare phosphate-based prodrugs of the antibiotic Ciprofloxacin. Therefore, our study will facilitate the rational design of new and more effective drug delivery systems for amine-containing drugs.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Application In Synthesis of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Computed Properties of 109-12-6.

Dong, Chencheng;Bao, Yan;Sheng, Tian;Yi, Qiuying;Zhu, Qiaohong;Shen, Bin;Xing, Mingyang;Lo, Irene M. C.;Zhang, Jinlong research published 《 Singlet oxygen triggered by robust bimetallic MoFe/TiO₂ nanospheres of highly efficacy in solar-light-driven peroxymonosulfate activation for organic pollutants removal》, the research content is summarized as follows. Sulfate-radical (SO·₄^–) based Advanced Oxidation Process (SR-AOP), which is mainly generated from peroxymonosulfate (PMS) activation, is an excellent route for water treatment. Bimetallic nanoparticles have been widely applied in electronic, chem., biol., and mech. fields, etc.; however, few researchers have attempted to adopt bimetallic nanoparticles in environmental remediation. Further, in recent years, element molybdenum (Mo) has addressed much more environmental field attention than ever. Although singlet oxygen (¹O₂) generated commonly in SR-AOPs, its generation mechanism remains controversial. Hence, in this work, bimetallic MoFe/TiO₂ nanospheres were rationally constructed via a facile two-step methodol. Undoubtedly, it exhibited superior performance for the degradation of organic pollutants (e.g., rhodamine, phenol, 4-chlorophenol and sulfadiazine) irradiated by simulated solar light. Both photo-generated electrons and transition metallic redox couples (i.e., Mo⁶⁺/Mo⁴⁺, Fe³⁺/Fe²⁺ and Mo⁴⁺/Fe³⁺) play vital roles in the PMS activation. Distinct from conventional SR-AOPs, sulfate radicals (SO^·_4-), hydroxyl radicals (^·OH) and peroxymonosulfate radicals (SO^·₅^–) indeed participate in the transformation and generation of singlet oxygen (¹O₂). With the combination of DFT calculation, the Mo sites on the bimetallic MoFe (110) facet are more favorable to adsorb PMS mols., then followed by the dissociation of PMS progressing on the Mo sites. Electrons transferring from the Mo atoms to the Fe atoms facilitated the adsorption of the neg. charged HSO_5- anions, resulting in enhanced PMS activation efficiency. Considering its novelty and generation mechanism, this work highlights the mechanism of ¹O₂ generation from PMS reduction and oxidation simultaneously and furnishes theor. support for further relevant studies.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Computed Properties of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. HPLC of Formula: 109-12-6.

El-Sayed, Yusif;Gaber, Mohamed;El-Wakeil, Nadia;Abdelaziz, ahmed;El-Nagar, Asmaa research published 《 Metal complexes of azo mesalamine drug: Synthesis, characterization, and their application as an inhibitor of pathogenic fungi》, the research content is summarized as follows. A novel azo dye ligand, formed by the coupling of 5-aminosalycalic acid (mesalamine drug) with 2-amino pyrimidine (H₂L) and its Co²⁺, Ni²⁺, and Cu²⁺ complexes, was synthesized. The structures of ligand and its complexes were described by elemental anal., inductively coupled plasma (ICP), TGA, magnetic moment measurements, molar conductance, UV-visible, x-ray powder diffraction, IR, ¹H-NMR, ¹³C NMR, and electron impact (EI) mass spectral studies. The obtained data detected that the H₂L ligand acts as monobasic tridentate via C:N, azo nitrogen, and deprotonated OH groups. The data supported the formation of 1:2 (M:L) for Co²⁺ complex, while Ni²⁺ and Cu²⁺ gave 1:1 (M:L) complexes mononuclear formulation. The Co²⁺ and Ni²⁺ complexes have octahedral structures, while Cu²⁺ complex has tetrahedral geometry. The ligand and its Co²⁺, Ni²⁺, and Cu²⁺ complexes were applied as an antifungal against a set of root rot-associated soil-born phytopathogenic fungi and compared with the effect of Hatric (recommended fungicide). The authors’ findings revealed that the metal complexes exhibited greater antifungal activity than the parent ligand. The Cu²⁺ complex is the most effective compound The effect of Hatric and Cu²⁺ complex on structural alterations of Fusarium semitectum was studied by SEM.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., HPLC of Formula: 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. COA of Formula: C4H5N3.

Cui, Hao;Tian, Yu;Zhang, Jun;Ma, Shanshan;Li, Lipin;Zuo, Wei;Zhang, Lei;Wang, Tong research published 《 Enhanced oxidation of sulfadiazine by two-stage ultrasound assisted zero-valent iron catalyzed persulfate process: Factors and pathways》, the research content is summarized as follows. The existence of sulfonamides (SAs) in water bodies leads to a series of human health problems and environmental risks. Ultrasound (US) enhanced zero-valent iron catalyzed persulfate (ZVI/PS) process is a potential approach to eliminate SAs. However, high energy consumption and large ZVI usage limited its application. In this study, a novel two-stage US-ZVI/PS process was first proposed, which reduced 35% of ZVI usage and saved 74.2% of energy consumption compared with traditional US-ZVI/PS process. The effect of introduction time and operation mode of US on sulfadiazine (SD, 20 mg L^-1) degradation was first investigated. The intermittent operation method of US (60 s on/60 s off) could help controlling the releasing of Fe²⁺ in a reasonable range (0.37-0.56 mg L^-1), which was the key reason for the high SD degradation efficiency. SO·-4, ·OH were confirmed as the key radicals for SD removal, and four degradation pathways were proposed. The initial pH of 5.0-7.0, the initial ZVI and PS doses of 0.6 mM and 1.4 mM were determined as the optimal conditions for high SD removal efficiency. Compared to other SD removal processes (traditional US/ZVI/PS, ozonation and UV-based process), two-stage US-ZVI/PS saved 68.3-98.5% energy consumption and enhanced 0.7-14.0 times degradation rate. Therefore, two-stage US-ZVI/PS system is promising and cost-effective for the removal of SD.

COA of Formula: C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. Electric Literature of 109-12-6.

Dash, Sibananda G.;Thakur, Tejender S. research published 《 Computational Screening of Multicomponent Solid Forms of 2-Aryl-Propionate Class of NSAID, Zaltoprofen, and Their Experimental Validation》, the research content is summarized as follows. A rational coformer screening methodol. was adopted to identify new multicomponent solid preformulations of the 2-aryl propionate class of nonsteroidal anti-inflammatory drugs. The coformer screening was performed using a modified mol. electrostatic potential based site-pair interaction energy computations used in conjunction with the free energy of cocrystal formation calculations to attain better predictability. The computational results were validated against the available exptl. data and used for optimizing the cocrystal screening methodol. for the drug zaltoprofen. A new polymorph and three new cocrystal forms of zaltoprofen were reported in the study, which exhibits up to four times enhancement in the drug solubility than that of the marketed form. We also report one new salt and two new cocrystals of (+)-ibuprofen, a drug from the same 2-aryl propionate family. In hindsight, we propose incorporating secondary heteromeric interactions formed by homo/heterodimer in the calculations of site-pair interaction energy differences for improving the predictability of the mol. electrostatic potential (MESP) based screening. A combined coformer screening strategy utilizing an MESP site-pair interaction energy and the free energy of cocrystal formation calculations helped to develop several novel multicomponent solids of zaltoprofen.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Electric Literature of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Quality Control of 109-12-6.

Decker, Ann M.;Brackeen, Marcus F.;Mohammadkhani, Aida;Kormos, Chad M.;Hesk, David;Borgland, Stephanie L.;Blough, Bruce E. research published 《 Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist》, the research content is summarized as follows. Human trace amine-associated receptor subtype 1 (hTAAR1) is a G protein-coupled receptor that has therapeutic potential for multiple diseases, including schizophrenia, drug addiction, and Parkinson’s disease (PD). Although several potent agonists have been identified and have shown pos. results in various clin. trials for schizophrenia, the discovery of potent hTAAR1 antagonists remains elusive. Herein, we report the results of structure-activity relationship studies that have led to the discovery of a potent hTAAR1 antagonist (RTI-7470-44, 34). RTI-7470-44 exhibited an IC₅₀ of 8.4 nM in an in vitro cAMP functional assay, a K_i of 0.3 nM in a radioligand binding assay, and showed species selectivity for hTAAR1 over the rat and mouse orthologues. RTI-7470-44 displayed good blood-brain barrier permeability, moderate metabolic stability, and a favorable preliminary off-target profile. Finally, RTI-7470-44 increased the spontaneous firing rate of mouse VTA dopaminergic neurons and blocked the effects of the known TAAR1 agonist RO5166017. Collectively, this work provides a promising hTAAR1 antagonist probe that can be used to study TAAR1 pharmacol. and the potential therapeutic role in hypodopaminergic diseases such as PD.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Quality Control of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Recommanded Product: Pyrimidin-2-amine.

Deng, Tianning;Mazumdar, Wrickban;Yoshinaga, Yuki;Patel, Pooja B.;Malo, Dana;Malo, Tala;Wink, Donald J.;Driver, Tom G. research published 《 Rh₂(II)-Catalyzed Intermolecular N-Aryl Aziridination of Olefins using Nonactivated N-Atom Precursors.》, the research content is summarized as follows. The development of the first intermol. Rh₂(II)-catalyzed aziridination of olefins using anilines as nonactivated N atom precursors and an iodine(III) reagent as the stoichiometric oxidant was reported. This reaction required the transfer of an N-aryl nitrene fragment from the iminoiodinane intermediate to a Rh₂(II)-carboxylate catalyst; in the absence of a catalyst only diaryldiazene formation was observed This N-aryl aziridination was general and was successfully realized using as little as 1 equiv of the olefin. Di-, tri- and tetrasubstituted cyclic- or acyclic olefins was employed as substrates and a range of aniline- and heteroarylamine N atom precursors were tolerated. The Rh₂(II)-catalyzed N atom transfer to the olefin was stereospecific, chemo- and diastereoselective to produce the N-aryl aziridine as the only amination product. Because the chem. of nonactivated N-aryl aziridines was underexplored, the reactivity of N-aryl aziridines was explored toward a range of nucleophiles to stereoselectively access privileged 1,2 stereodiads unavailable from epoxides, and removal of the N-2,4-dinitrophenyl group was demonstrated to show that functionalized primary amines was constructed.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Recommanded Product: Pyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. COA of Formula: C4H5N3.

Dharuman, Suresh;Wallace, Miranda J.;Reeve, Stephanie M.;Bulitta, Jurgen B.;Lee, Richard E. research published 《 Synthesis and Structure-Activity Relationship of Thioacetamide-Triazoles against Escherichia coli》, the research content is summarized as follows. Infections due to Gram-neg. bacteria are increasingly dangerous due to the spread of multi-drug resistant strains, emphasizing the urgent need for new antibiotics with alternative modes of action. Authors have previously identified a novel class of antibacterial agents, thioacetamide-triazoles, using an antifolate targeted screen and determined their mode of action which is dependent on activation by cysteine synthase A. Herein, authors report a detailed examination of the anti-E. coli structure-activity relationship of the thioacetamide-triazoles. Analogs of the initial hit compounds were synthesized to study the contribution of the aryl, thioacetamide, and triazole sections. A clear structure-activity relationship was observed generating compounds with excellent inhibition values. Substitutions to the aryl ring were generally best tolerated, including the introduction of thiazole and pyridine heteroaryl systems. Substitutions to the central thioacetamide linker section were more nuanced; the introduction of a Me branch to the thioacetamide linker substantially decreased antibacterial activity, but the isomeric propionamide and N-benzamide systems retained activity. Changes to the triazole portion of the mol. dramatically decreased the antibacterial activity, further indicating that 1,2,3-triazole is critical for potency. From these studies, authors have identified new lead compounds with desirable in-vitro ADME properties and in-vivo pharmacokinetic properties.

COA of Formula: C4H5N3, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia