Category: 109-12-6

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Formula: C4H5N3.

Belardinelli, Juan M.;Li, Wei;Martin, Kevin H.;Zeiler, Michael J.;Lian, Elena;Avanzi, Charlotte;Wiersma, Crystal J.;Nguyen, Tuan Vu;Angala, Bhanupriya;de Moura, Vinicius C. N.;Jones, Victoria;Borlee, Bradley R.;Melander, Christian;Jackson, Mary research published 《 The 2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner》, the research content is summarized as follows. Biofilm growth is thought to be a significant obstacle to the successful treatment of Mycobacterium abscessus infections. A search for agents capable of inhibiting M. abscessus biofilms led to our interest in 2-aminoimidazoles and related scaffolds, which have proven to display antibiofilm properties against a number of Gram-neg. and Gram-pos. bacteria, including Mycobacterium tuberculosis and Mycobacterium smegmatis. The screening of a library of 30 compounds led to the identification of a compound, AB-2-29, which inhibits the formation of M. abscessus biofilms with an IC₅₀ (the concentration required to inhibit 50% of biofilm formation) in the range of 12.5 to 25μM. Interestingly, AB-2-29 appears to chelate zinc, and its antibiofilm activity is potentiated by the addition of zinc to the culture medium. Preliminary mechanistic studies indicate that AB-2-29 acts through a distinct mechanism from those reported to date for 2-aminoimidazole compounds

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Formula: C4H5N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). COA of Formula: C4H5N3.

Olyaei, Abolfazl;Ebrahimi, Sepideh;Sadeghpour, Mahdieh research published 《 Convenient one-pot synthesis of some novel heteroaryl aminoindandione derivatives》, the research content is summarized as follows. An efficient, one-pot, three-component synthesis of some heteroaryl aminoindandiones I [Ar = 2-pyridyl, 4-methyl-2-pyridyl, 4,6-dimethylpyrimidin-2-yl, etc.] using ninhydrin, heteroaryl amines and barbituric/2-thiobarbituric acids catalyzed by p-toluenesulfonic acid as organocatalyst was achieved within a short period of time. The present methodol. offered several advantages included operational simplicity, clean reaction, high yield, short reaction times, high atom economy, easy workup procedure and simple purification of products by nonchromatog. methods.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., COA of Formula: C4H5N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The systematic study of pyrimidines began in 1884 with Pinner, who synthesized derivatives by condensing ethyl acetoacetate with amidines. Pinner first proposed the name “pyrimidin” in 1885. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The parent compound was first prepared by Gabriel and Colman in 1900, by conversion of barbituric acid to 2,4,6-trichloropyrimidine followed by reduction using zinc dust in hot water. HPLC of Formula: 109-12-6.

Rana, Bidyut K.;Roymahapatra, Gourisankar;Das, Himadri Sekhar;Giri, Santanab;Cardoso, Marlon H.;Franco, Octavio L.;Kiran, N. K.;Santra, Manas K.;Bag, Partha Pratim;Bertolasi, Valerio;Dinda, Joydev research published 《 Pyridine and pyrimidine functionalized half-sandwich Ru(II)-N heterocyclic carbene complexes: Synthesis, structures, spectra, electrochemistry and biological studies》, the research content is summarized as follows. New set of Ru-N-Heterocyclic Carbene (Ru-NHC) complexes 1a and 2a were synthesized from their ligand precursors 1-Methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate (1) and 1-Methyl-2-pyrimidin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate (2). The mols. were characterized and their structures were investigated through single crystals X-ray diffraction. The overall coordination around the Ru center can be described as a half-sandwich geometry. Absorption spectra and electrochem. behavior of the complexes were also evaluated, supported by DFT anal. The complexes were applied on lung (A549), colon (HCT116) and breast (MCF7) cancer cells to examine their in vitro cytotoxicity activity.

HPLC of Formula: 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Application In Synthesis of 109-12-6.

Olyaei, Abolfazl;Taheri, Neda;Sadeghpour, Mahdieh research published 《 Solvent and catalyst-free synthesis of some new aminonaphthoquinones from lawsone, ninhydrin and heteroaryl amines》, the research content is summarized as follows. An efficient and easy method was developed for the preparation of some new aminonaphthoquinone derivatives from a one-pot three-component condensation of 2-hydroxy-1,4-naphthoquinone, ninhydrin and heteroaryl amines under catalyst and solvent-free conditions at 75°C. The protocol described in-situ generated imine as intermediate from the condensation reaction of ninhydrin with heteroaryl amines followed by the addition of 2-hydroxynaphthalene-1,4-dione to the imine, afforded the desired products. The operational simplicity of the procedure, shorter reaction times, simple workup procedure, clean reaction, easy purification of products by non-chromatog. methods, environmentally friendly conditions and high yields made this method much attractive.

Application In Synthesis of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Name: Pyrimidin-2-amine.

Rana, Bidyut K.;Roymahapatra, Gourisankar;Das, Himadri Sekhar;Giri, Santanab;Cardoso, Marlon H.;Franco, Octavio L.;Nakka, Kiran K.;Santra, Manas K.;Bag, Partha Pratim;Bertolasi, Valerio;Dinda, Joydev research published 《 Pyridine and pyrimidine functionalized half-sandwich Ru(II) N-heterocyclic carbene complexes: Synthesis, structures, spectra, electrochemistry and biological studies》, the research content is summarized as follows. New set of Ru N-Heterocyclic Carbene (Ru-NHC) complexes 1a and 2a were synthesized from their ligand precursors 1-Methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate (1) and 1-Methyl-2-pyrimidin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium hexafluorophosphate (2). The mols. were characterized and their structures were investigated through single crystals X-ray diffraction. The overall coordination around the Ru center can be described as a half-sandwich geometry. Absorption spectra and electrochem. behavior of the complexes were also evaluated, supported by DFT anal. The complexes were applied on lung (A549), colon (HCT116) and breast (MCF7) cancer cells to examine their in vitro cytotoxicity activity.

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Name: Pyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Name: Pyrimidin-2-amine.

Abdelshafi, N. S.;Sadik, M. A.;Shoeib, Madiha A.;Halim, Shimaa Abdel research published 《 Corrosion inhibition of aluminum in 1 M HCl by novel pyrimidine derivatives, EFM measurements, DFT calculations and MD simulation》, the research content is summarized as follows. Four pyridine-pyrimidine derivatives, namely pyridine-2,6-diamine (PD), pyrimidine-2-amine (PA), 6-amino-3,4-dihydropyrimidine-2(1H)-thione (ADT) and Et (R)-6-(4-chlorophenyl)-2-mercapto-4-methyl-1,6-dihydropyrimidine-5-carboxylate (EMMD) are used as effective inhibitors for aluminum corrosion in 1 M HCl solution The anti-corrosive potential of these heterocyclic compounds has been evaluated by electrochem. frequency modulation (EFM) method, The inhibition efficiency of these inhibitors was strongly associated to the concentration (10^-7-10^-3 M) and the structure of the mols.; reached a maximum of 95.68% for EMMD at 10^-3 M owing to more anchoring functional groups. The effect of temperature on the corrosion behavior was assessed at solution temperature range 298-323 K. The four inhibitors adsorbed according to the Langmuir’s adsorption isotherm. Thermodn. activation parameters for the dissolution process of aluminum in 1 M HCl and inhibited solutions were calculated and discussed. Surface anal. (SEM, EDX, and AFM) confirmed the formation of a protective layer adsorbed on the aluminum surface. In addition, theor. studies by DFT and MD revealed the correlation between the mol. chem. structure of studied inhibitors and their inhibition efficiency. The adsorption mechanism is revealed by theor. calculations

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Name: Pyrimidin-2-amine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Quality Control of 109-12-6.

Abu-Dief, Ahmed M.;El-khatib, Rafat M.;Aljohani, Faizah S.;Alzahrani, Seraj Omar;Mahran, Asmaa;Khalifa, Mohamed E.;El-Metwaly, Nashwa M. research published 《 Synthesis and intensive characterization for novel Zn(II), Pd(II), Cr(III) and VO(II)-Schiff base complexes; DNA-interaction, DFT, drug-likeness and molecular docking studies》, the research content is summarized as follows. A novel bioactive series was synthesized from Zn(II), Pd(II), Cr(III) and VO(II) ions with a new Schiff base derivative (HNP) [HNP = 1-(Pyrimidin-2-yliminomethyl)-naphthalen-2-ol]. The proposed structures were defined from elemental anal., molar conductivity, magnetic moment, IR, ¹H NMR, UV-visible, and TGA. Based on anal. and spectroscopic data, suitable geometry was suggested for all complexes. The HNP ligand acts as a tri-dentate via NNO donors towards the metal ions inside octahedral geometry with Cr(III), square pyramidal with VO(II), tetrahedral with Zn²⁺ and square planner with Pd²⁺ ion. The kinetic and thermodn. parameters of complexes were determined by using Coats-Redfern method and their values suggested that the activated complexes were more ordered. The binding efficiency of the investigated complexes with calf thymus DNA (ctDNA), was examined by using different methods and the binding feature was suggested to be electrostatic, intercalation, or replacement mode. Also, in-vitro antimicrobial and anticancer potency of the compounds were evaluated. The new complexes showed an effective impact on decreasing cell viability of breast carcinoma cells (MCF-7) in a concentration-dependent manner. In-vitro antioxidant activity of all compounds was investigated and the results showed appreciated free radical scavenging activity of Pd(II) complex. Also, Mol. docking inspection was carried out to explain the binding affinity of the tested compounds towards breast cancer cell-protein (PDB: 3hb5).

Quality Control of 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109-12-6, name is Pyrimidin-2-amine. A new synthetic method of this compound is introduced below., Formula: C4H5N3

General procedure: To a Schlenk tube charged with Pd2(dba)3 (2 mol %) and Xantphos (3 mol %) was added 2-aminopyrimidine (1 mmol) and NaOtBu (1 mmol). The tube was evacuated and backfilled with Ar three times. Toluene (1 mL /mmol aryl halide) was then added via syringe followed by aryl bromide (0.5 mmol) by syringe.The mixture was heated to 95 C. Once deemed complete (TLC) the reaction mixture wascooled, filtered through a pad of Celite, washed with EtOAc (20 mL) and diluted with water (20ml), then extracted with EtOAc (3 x 20 mL). The organic layers were then combined, washedwith brine (50 mL), dried over MgSO4 and concentrated under reduced pressure. The product was then purified using column chromatography (hexanes: ethyl acetate, gradient from 20-70%ethyl acetate).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109-12-6, Pyrimidin-2-amine.

Reference:
Article; Shaw, Julian W.; Grayson, David H.; Rozas, Isabel; ARKIVOC; vol. 2014; 2; (2014); p. 161 – 174;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 109-12-6, Pyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 109-12-6, blongs to pyrimidines compound. Product Details of 109-12-6

General procedure: 0.5 mol% ruthenium(II) catalyst was stirred with 4 mmol ofKOH in toluene. To this mixture, 2 mmol of alcohol and 2 mmolof amine were added and the temperature was raised up to120 C. The progress of the reactions was monitored using TLC.As soon as the reaction was completed, the mixture was cooledto room temperature and added 3 mL of distilled water. The combinedmixture was extracted with CH2Cl2 and dried by addingmagnesium sulfate. The crude product was purified by columnchromatography (n-hexane/EtOAc) and characterized by 1H NMRspectral analyses. The 1H NMR data obtained for the catalytic productswere compared with literature [19].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-12-6, its application will become more common.

Reference:
Article; Prakash, Govindan; Ramachandran, Rangasamy; Nirmala, Muthukumaran; Viswanathamurthi, Periasamy; Sanmartin, Jesus; Inorganica Chimica Acta; vol. 427; (2015); p. 203 – 210;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 109-12-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109-12-6, name is Pyrimidin-2-amine. A new synthetic method of this compound is introduced below.

General procedure: Alcohol (1.00 mmol)and amine (1.10 mmol) were weighed into an oven-dried Schlenkflask containing 4A molecular sieves (60 mg). tBuOK (0.50 mmol)was added, followed by dry toluene (0.50 mL). The mixture wasput under an atmosphere of nitrogen, and catalyst (0.01 mmol)was added before stoppering the flask and immersing it in a pre-heated oil bath (110C) for 48 h. Then, the solvent was evaporatedand the crude solid was purified by column chromatography using petroleum ether and triethylamine. The analytical data of all products are consistent with the data reported in literature [6j,8,11e].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-12-6, its application will become more common.

Reference:
Article; Zhu, Xiao-Han; Cai, Li-Hua; Wang, Chen-Xi; Wang, Ya-Nong; Guo, Xu-Qing; Hou, Xiu-Feng; Journal of Molecular Catalysis A: Chemical; vol. 393; (2014); p. 134 – 141;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia