Category: 1100318-96-4

Reference of 1100318-96-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1100318-96-4, name is 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4IN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

K2CO3 was added to a solution of 4-iodo-7H-pyrrolo[2,3-d]pyrimidine (4) in dry DMF and then stirred for 30 min at room temperature. After 30 min, 2-(trimethylsilyl)ethoxymethyl chloride was added drop-wise to the solution, and the reaction was stirred for 6 h at room temperature. For quenching, saturated NH4Cl aqueous solution was added. The mixture was poured into ethyl acetate and extracted twice. The combined organic layers were dried with Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to yield the desired compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1100318-96-4, 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Article; Lee, Sun-Mi; Yoon, Kyoung Bin; Lee, Hyo Jeong; Kim, Jiwon; Chung, You Kyoung; Cho, Won-Jea; Mukai, Chisato; Choi, Sun; Kang, Keon Wook; Han, Sun-Young; Ko, Hyojin; Kim, Yong-Chul; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5036 – 5046;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1100318-96-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1100318-96-4, name is 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4IN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[00304] 206 mg (0.84 mmol) of 4-iodo-7H-pyrrolo[2,3-d]pyrimidine was dissolved in 1 ml_ DMF. 37 mg (0.92 mmol) of 60% sodium hydride was added followed by 58 mul_ (0.92 mmol) of iodomethane. The reaction was quenched by adding 10 ml_ of water, the solid filtered off, washed with 10 ml_ of water, then 10 ml_ of hexanes and dried. Yield: 142 mg of a tan powder, 90% pure.

According to the analysis of related databases, 1100318-96-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2009/9740; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1100318-96-4, Adding some certain compound to certain chemical reactions, such as: 1100318-96-4, name is 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C6H4IN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1100318-96-4.

[00349] 4-lodopyrrolo[2,3-d]pyrimidine(2b, 50.3 g, 95.5% purity, 196 mmol) was dissolved/suspended in 0.64 L of anhydrous THF in a three- necked 2 L round bottom flask under nitrogen atmosphere, equipped with a mechanical stirrer and a thermometer. The solution was cooled down to -15 0C in a dry ice-acetone bath and 206 ml_ of a 1.0 M o-tolylmagnesium chloride THF solution (1.05 equiv.) was added slowly, so the internal temperature would not exceed -10 C. During the addition all of the solids dissolved. The cooling bath was removed and 104 ml_ of a 1.95 M isopropylmagnesium chloride THF solution (1.03 equiv.) was added over a period of 3 minutes. During the addition tan solids precipitate; the stirring should be vigorous to avoid clumping. The resulting solution was warmed rapidly to room temperature using warm water bath. To this suspension, 59.9 g of the nitrile sodium salt (19, 0.77 equiv.) in 120 ml_ dry THF was added and the resulting mixture was stirred at 45 C for 16 hours. The mixture was cooled down in an ice bath and 101 mL of 36% aqueous HCI was added dropwise, so the internal temperature would not exceed 30 C, while vigorously stirred. Yellow solids precipitated and the entire thick suspension was mechanically stirred for 30 minutes at 50 0C (yellow solids become orange), cooled down to room temperature and then filtered. The solids were washed with 700 mL of THF, followed by 700 mL of diethyl ether, followed by two 1 L portions of 1 M aqueous HCI. The resulting wet orange solid was taken up in a mixture of 0.9 L ethyl acetate, 0.5 L water and 50 g of sodium bicarbonate and stirred until completely dissolved. The solution was filtered through a pad of CELITE and the layers were separated. The aqueous layer was extracted with 50 mL of ethyl acetate. The combined organic layers were filtered through a pad of 200 g of silica gel, followed by washing silica with additional 0.8 L of ethyl acetate. The solution was concentrated down in vacuo to yield 56.5 g of the product as a yellow solid (contains 2 wt % of ethyl acetate, yield 74 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1100318-96-4, 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2009/9740; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1100318-96-4, 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, blongs to pyrimidines compound. Safety of 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine

Dry DMFWas added K2CO3 to a solution of 4-iodo-7h-pyrrolo [2,3-d] pyrimidine (4) and the mixture was stirred at room temperature for 30 minutes. After 30 minutes, 2- (trimethylsilyl) ethoxymethyl chloride was added dropwise to the solution,The reaction was stirred for 6 hours. For quenching, a saturated aqueous NH4Cl solution was added to the solution. The mixture was poured into ethyl acetate and extracted twice with ethyl acetate. The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography (hexane / ethyl acetate) to give the desired compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1100318-96-4, 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Gwangju Institute of Science and Technology; INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY; Kim, Yong-Chul; Han, Son-Young; Ko, Hyo-Jin; Lee, Son-Mi; (28 pag.)KR2016/124034; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1100318-96-4, name is 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

306) To a solution of 4-iodo-7H-pyrrolo[2,3-d]pyrimidine (2784.4 mg, 11.36 mmol) in dry THF (30.0 mL) was added pyridine (0,92 mL, 1 1.34 mmol), DIAD (4,7 mL, 23.82 mmol), tributylphosphane (5.7 mL, 22.68 mmol) and [(R)-(4-chlorophenyl)-[(2S,3S,4R)-3,4,5- trihydroxytetrahydrofuran -2-yl] methyl] 4-phenylbenzoate (Int-2-3) (5000.0 mg, 11.34 mmol) under N2. The reaction mixture was stirred at 30 C for 1 h under N2. LCMS showed the reaction was completed. The mixture was purified by silica chromatography column (DCM : CH OH = 100 : 1 to 60 : 1) to give [(R)-(4-chlorophenyl)-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(4-iodopyrrolo[2,3- d]pyrimidin-7-yl)tetrahydrofuran-2-yl]methyl] 4-phenylbenzoate (104a) (2.0 g, 2.99 mmol, 26.4% yield). LCMS [M+H] : 668.2.

With the rapid development of chemical substances, we look forward to future research findings about 1100318-96-4.

Reference:
Patent; PRELUDE THERAPEUTICS, INCORPORATED; LUENGO, Juan; LIN, Hong; (0 pag.)WO2018/160855; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1100318-96-4, name is 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below., Product Details of 1100318-96-4

Description 84; 1,1 -Dimethylethyl (4-iodo-7H-pyrrolo[2,3-cf]pyrimidin-7-yl)acetate (D84)To a solution of 4-iodo-7H-pyrrolo[2,3-d]pyrimidine (3 g, 8.07 mmol) in dry N, N- dimethylformamide (50 ml.) was added sodium hydride (0.71 g, 17.75 mmol) portionwise and the mixture stirred for 10 minutes to give a clear solution. tert-Butyl bromoacetate (2.62 ml_, 17.75 mmol) was added and the mixture stirred for 1 hour. Ethyl acetate (250 ml.) was added and washed with water (2×200 ml_). Dried over magnesium sulfate and solvent evaporated to give a yellow oil. A small amount of solid started to form. Ether (10 ml.) was added followed by hexane (40 ml.) and a white solid slowly precipitated. After collection and washing with hexane the title compound was obtained as a white solid. LC/MS (ES+ve): [M+H]+ at m/z 360 (Ci2H14IN3O2 requires [M+H]+ at m/z 360).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1100318-96-4, 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/80682; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia