Category: 110099-94-0

Electric Literature of 110099-94-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110099-94-0, name is 2-(Methylthio)pyrimidine-5-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of crude 19 (100 mg, 0.48 mmol ) in THF (5 mL) is added isobutyl chloroformate (0.05 mL, 0,58 mmol) followed by NMM (0.06 mL, 0.58 mmol) at – 10 C. After stirring for 10 minutes, the mixture is filtered and sodium borohydride (37 mg, 0,96 mmol) in water (0.2 mL) is added dropwise at 0 C. After stirring at room temperature for 20 minutes, the mixture is concentrated and the residue is partitioned between EA (20 mL) and water (10 mL). The organic layer is washed with brine (10 mL), dried over anhydrous sodium sulfate, concentrated, and purified by silica gel column chromatography (MeOH:DCM = 1 : 100) to give A38 as a colorless oil (50 mg, 74% yield). (MS: i 1 · 1 11 194.1 ).Following the procedure for A38 using 133 (1.18 g, 6.9 mmoi), NMM (695 mg.6.9 mmoi), THF (20 mL), isohutyl chioroformate (1.13 g. 8.25 mmol), sodium borodeuteride(289 mg, 6.9 mmoi), and deueterate water (0.5 mL), then purii with silica gel columnchromatography (EA:PE == 1:5) to give i13d2 as a light yellow solid (290 rng, 25%). (MS:[M+H] 159.1)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110099-94-0, 2-(Methylthio)pyrimidine-5-carboxylic acid.

Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110099-94-0, name is 2-(Methylthio)pyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below., Formula: C6H6N2O2S

The N-{5-[(cyclopropylamino) carbollyl]-2-methylphenyl}-2-(methylthio) pyrimidine- 5-carboxamide used as starting material was prepared as follows:- To a solution of2- (methylthio) pyrimidine-5-carboxylic acid (1. 50g, 8.82 mmol) and 3-amino-N-cyclopropyl-4-methylbenzamide (1. 6Sg, 8.82 mmol) in DMF (7.5 mL) was added HATU (3.69 g, 9.70 mmol) and DIPEA (4. 30 mL, 26.46 mmol) and the resulting mixture stirred for 16 h at room temperature. Saturated aqueous sodium bicarbonate was added and the mixture extracted with ethyl acetate, washed with brine and concentrated under reduced pressure to give the title compound as a solid (3.04 g, 100%); NMR Spectrum: (DMSOdo) 0.57 (m, 2H), 0.69 (m, 2H), 2. 28 (s, 3H), 2.60 (s, 3H), 2.86 (m, 1H), 7.36 (m, 1H), 7.65 (m, 1H), 7.85 (m, 1H), 8.39 (m, 1H), 9.12 (s, 2H), 10. 18 (m, 1H) ; Mass Spectrum : M-H-341.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 110099-94-0, 2-(Methylthio)pyrimidine-5-carboxylic acid.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/61465; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia