Category: 110100-00-0

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110100-00-0, name is 1-(2-Chloropyrimidin-5-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H5ClN2O

To a stirred solution of Intermediate 16 (1.14 g, 4.24 mmol) in dry DMF (10 mL), TEA (1.1 mL, 16.5 mmol) and 1-(2-chloropyrimidin-5-yl)ethan-1-one obtained in the previous step (0.6 g, 3.85 mmol) were added at rt. The resulting mixture was heated to 90 C for 12 h. It was cooled to rt and concentrated. Dichloromethane (50 mL) was added and was washed with a saturated NaCI solution (10 mL), dried over anhydrous Na2SO4 and concentrated. The crude product was purified by flash chromatography, affording the title compound (off white solid). 1H NMR (400 MHz, DMSO-d6): delta 8.83 (s, 2H), 6.90 (s, 1H), 6.84 (d, J = 7.6 Hz, 1H), 6.74 (dd, J = 8.0, 1.2 Hz, 1H), 5.99-5.98 (m, 2H), 3.84 (t, J = 4.8 Hz, 4H), 3.40-3.36 (m, 1H), 2.49-2.47 (m, 5H), 2.38-2.35 (m, 2H), 1.27 (d, J = 6.8 Hz, 3H). LCMS: (Method A) 355.0 (M+H), Rt. 2.61 min, 99.78% (Max). HPLC: (Method A) Rt. 2.55 min, 99.51 % (Max).

With the rapid development of chemical substances, we look forward to future research findings about 110100-00-0.

Reference:
Patent; ASCENEURON SA; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; (243 pag.)WO2016/30443; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 110100-00-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110100-00-0, name is 1-(2-Chloropyrimidin-5-yl)ethanone, molecular formula is C6H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1. In a microwave oven, 1.000 g (6.387 mmol) of 1- (2-chloropyrimidin-5-yl) ethanone,1.236g (7.664mmol) (1R, 2S) -2,6-dimethylindene-1-amineA mixture of 2.476 g (19.161 mmol) of N, N-diisopropylethylamine in 8.0 mL of 1,4-dioxane was heated at 140 C for 45 minutes.The solvent was removed under reduced pressure, water and dichloromethane were added to the mixture, and the aqueous phase was extracted twice with dichloromethane.The combined organic phases were dried over sodium sulfate, and the solvent was distilled off under reduced pressure. : 50)] purification residue,Yielded 1.630 g (85%)1- (2-{[(1R, 2S) -2,6-dimethyl-2,3-dihydro-1H-inden-1-yl] amino} pyrimidin-5-yl) ethanone.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110100-00-0, 1-(2-Chloropyrimidin-5-yl)ethanone.

Reference:
Patent; Baier Crop Science Co., Ltd.; Baier Corporation; H ¡¤zhankebi; E ¡¤busikatuo¡¤aersaikeer; K ¡¤maien; U ¡¤duole; H ¡¤ditelixi; E ¡¤jiaciweile; A ¡¤B¡¤maqiedila; C ¡¤H¡¤luoxinge; D ¡¤shimucile; (88 pag.)CN110461833; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia