Pyrimidine, also known as pyrimidine base or 1, 3-diazin, belongs to the class of organic compounds known as pyrimidines and pyrimidine derivatives.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1111237-76-3, its application will become more common.
Electric Literature of 1111237-76-3 ,Some common heterocyclic compound, 1111237-76-3, molecular formula is C7H5BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 5-bromo-4-chloro-2-methyl-7H-pyrrolo[2,3-
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1111237-76-3, 5-Bromo-4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine.
Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1111237-76-3, name is 5-Bromo-4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines
b) Preparation of intermediate 152; A solution of intermediate 151 (0.01014 mol) in THF (50 ml) was stirred under N2- flow at -78 0C and a solution of n-BuLi 2.5M (0.0305 mol) in THF (10 ml) was added dropwise. After addition, the reaction was continued for one hour at -78 C. A solution of DMF (0.02029 mol) in THF (10 ml) was added dropwise. The reaction mixture was stirred for 30 min at -78 0C. The reaction mixture was allowed to reach -30 0C, and H2O (10 ml) was added dropwise. The reaction mixture was stirred for 30 min. The organic layer was separated and filtered over silica gel (eluent: THF). The collected fractions were concentrated under reduced pressure and the residue was stirred in a mixture of 2% CH3OH and 98% DCM. The precipitate was filtered off, washed and dried under vacuo, yielding 0.85 g (42.8%) of intermediate 152.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1111237-76-3, 5-Bromo-4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/16132; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia