Category: 111196-81-7

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Chloro-5-ethylpyrimidine

<142> Preparation Example l:Synthesis of l-(5-methyl-pyrimidin-2-yl )- din-4- l<144> Under a nitrogen atmosphere, in a 500ml flask, 9.6g of 4- hydroxypiper idine and 250ml of 2:1 acetonitr i le/dist i 1 led water-solution were placed, stirred and dissolved. Then, 19.5ml of di isopropylethylamine and 11.2g of 2-chloro-5-ethylpyr imidine were added thereto, followed by heating and reflux for 2.5 days or more. The temperature was lowered to a room temperature, and the resultant product was dissolved in 200ml of IN HC1 aqueous solution, and washed with 200ml of ethyl acetate. The aqueous layer was adjusted to pH 7 by using IN NaOH aqueous solution, and was extracted with 200mL of ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate and vacuum-dried so as to provide a target compound. H NMR (400MHz, CDC13): 8.18(2H, s), 4.37-4,48(2H, m), 3.91-4.0K 1H, m) ,3.22-3.3K2H, m), 2.42-2.5K2H, m) , 1.49-1.99(4H, m) , 1.17-1.2K3H, m).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 111196-81-7, 2-Chloro-5-ethylpyrimidine.

Reference:
Patent; HYUNDAI PHARM CO., LTD.; PARK, Yong Kyu; BANG, Sung Hun; KIM, Jin Woong; LEE, Han Kyu; KIM, Jae Hyun; SON, Chang Mo; LEE, Jun Hee; SHIN, Chang Yong; LEE, Jong Chan; RHEE, Jae Keol; WO2012/11707; (2012); A2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111196-81-7, name is 2-Chloro-5-ethylpyrimidine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Chloro-5-ethylpyrimidine

3-Hydroxypropylamine (5.62 mL, 73.5 mmol, 1.2 equiv. ) was dissolved in 250 mL of TMOF/MEOH (1: 5) (TMOF = TRIMETHYL ORTHOFORMATE) and then 2,4- bis (trifluoromethyl) benzaldehyde (14.83g, 61.2 mmol, 1.0 equiv. ) was added to this solution at room temperature with stirring. The resulting solution was stirred at rt for 6 hours and then cooled to 0C. NaBH4 was added to the cooled reaction solution in portions with vigorous stirring. After TLC indicated the reduction complete, the reaction mixture was concentrated under reduced pressure. The residue was diluted with 250 mL of ethyl acetate and washed with water, brine and then dried over NA2SO4. After removal of solvent, 17.1 g (93% yield) colorless oil was obtained as desired N-2,5- bis (trifluoromethyl) benzyl-3-hydroxypropylamine (1C). H NMR (400 MHz, CDCL3), 8 (ppm): 7.9 (s, 1H), 7.75 (M, 2H), 4.0 (s, 2H), 3.8 (t, 2H), 2.85 (t, 2H), 1.76 (M, 2H). To a high pressure flask was added intermediate (1C) (12.23g, 40.6 mmol, 1.0 equiv. ), 2-chloro-5-ethylpyrimidine (4.9 mL, 40.6 mmol, 1.0 equiv. ), triethylamine (11.3 mL, 81.2 mmol, 2.0 equiv. ) and 50 mL of toluene. After the flask was sealed, it was heated to 180C with stirring. After reaction at same temperature for 48 hours, the reaction mixture was cooled to room temperature and then diluted with 100 mL of ethyl acetate. The resulting solution was washed with water, brine and the dried over NA2S04.- After removal of solvent, the residue was purified by chromatography to give 7.7 g (46% yield) of product (LE) as bright brown SOLID. H NMR (400 MHz, CDC13), 8 (ppm): 8. 15 (s, 2H), 7.90 (s, 1H), 7.67 (d, 1H) 9 7.30 (d, 1H), 5.02 (s, 2H), 3.71 (m, 2H), 3.53 (m, 2H), 2.42 (Q, 2H), 1.75 (M, 2H), 1.15 (T, 3H).

The synthetic route of 111196-81-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KALYPSYS, INC.; WO2004/92130; (2004); A2;,
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Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. A new synthetic method of this compound is introduced below., Quality Control of 2-Chloro-5-ethylpyrimidine

To a solution of 4-hydroxypiperidine (710 mg) in ethanol (5 mL) was added 5-ethyl-2-chloropyrimidine (425 muL), and the mixture was stirred at 80C overnight. To the reaction mixture was added water, and then the mixture was extracted with ethyl acetate, and the organic layer was dried over magnesium sulfate and then filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by column chromatography on silica gel (solvent; chloroform/methanol = 100/0 to 90/10) to give 1-(5-ethylpyrimidin-2-yl)piperidin-4-ol (699 mg) as a colorless solid (yield: 96%). MS(APCI)m/z; 208[M+H]+.

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Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2390254; (2011); A1;,
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Electric Literature of 111196-81-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Step-4: Synthesis of 5-ethyl-2-(5,6-dihydro-4-(4-(4-(methyl sulfonyl)phenyl)-1,2,5-thiadiazol-3-yl)pyridin-1(2H)-yl)pyrimidine To a stirred solution of 1,2,3,6-tetrahydro-4-(4-(4-(methylsulfonyl)phenyl)-1,2,5-thiadiazol-3-yl)pyridine hydrochloride (0.04 g, 0.111 mmol) and 2-chloro-5-ethylpyrimidine (0.023 g, 0.166 mmol) in DMF (5 mL) was added DIPEA (0.45 mL, 0.555 mmol) and stirred at 100 C. for 16 h. Reaction was monitored by TLC. On completion reaction mass was quenched with water, extracted with ethyl acetate. The organic layer was washed with water, brine, dried over sodium sulphate evaporated under reduced pressure obtained crude which was purified by silica gel (100-200 Mesh) column chromatography, eluent 25% EtOAc/Hexane to afford 5-ethyl-2-(5, 6-dihydro-4-(4-(4-(methylsulfonyl)phenyl)-1,2,5-thiadiazol-3-yl)pyridin-1(2H)-yl)pyrimidine (0.024 g, 51.06%) as off white solid. MS: 428.11 [M++1]

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111196-81-7, 2-Chloro-5-ethylpyrimidine.

Reference:
Patent; Mankind Pharma Ltd.; Patil, Rakesh Ishwar; Verma, Jeevan; Kumar, Puneet; Gunjal, Amol Pandurang; Rai, Himanshu; Rai, Santosh Kumar; Kumar, Anil; (106 pag.)US2017/291894; (2017); A1;,
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Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 111196-81-7

[0570] A mixture of (S)-3-((4-bromo-2-fluorophenoxy)methyl)pyrrolidine hydrochloride (1.70 g, 5.5 mmol), 2-chloro-5-ethylpyrimidine (0.85 g, 6.1 mmol) and diisopropylethylamine (1.77 g, 13.8 mmol) in dimethylformamide (150 mL) was stirred at 130oC overnight. After cooling to ambient temperature, dimethylformamide was removed under reduced pressure and the residue was treated with water (200 mL). A brown precipitate was formed which was filtered and re-dissolved in methylene chloride until the solution was clear. This was then dried over sodium sulfate, and filtered through a 3 cm silica gel pad. The solution was then evaporated in vacuo and the residue was purified by column chromatography by eluting with hexanes-ethyl acetate mixture (4:1) to obtain the title product (1.3 g, 62%) as colorless crystals. 1H-NMR (400 MHz, DMSO-d6) delta 8.21 (s, 2H), 7.52 (d, J = 8.7 Hz, 1H), 7.32 (d, J = 8.7Hz, 1H), 7.19 (t, J =8.7 Hz, 1H), 4.17-4.02 (m, 2H), 3.77-3.58 (m, 2H), 3.53-3.35 (m, 2H), 2.87-2.73 (m, 1H),2.41 (q, J = 7.5 Hz, 2H), 2.22-2.11 (m, 1H), 1.94-1.80 (m, 1H), 1.12 (t, J = 7.5 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 111196-81-7, 2-Chloro-5-ethylpyrimidine.

Reference:
Patent; PRAMANA PHARMACEUTICALS INC.; CHAFEEV, Mikhail; (240 pag.)WO2019/104418; (2019); A1;,
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Pyrimidine – Wikipedia

Application of 111196-81-7 ,Some common heterocyclic compound, 111196-81-7, molecular formula is C6H7ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of(S)-3-((4-bromophenoxy)methyl)pyrrolidine hydrochloride (1.15 g, 3.9 mmol), 2- chloro-5-ethylpyrimidine (0.62 g, 4.3 mmol) and diisopropylethylamine (1.27 g, 9.7 mmol) in dimethylformamide (50 mL) was stirred at 130C overnight. After cooling to ambient temperature, dimethylformamide was removed under reduced pressure and the residue was treated with water (200 mL). A brown precipitate was formed and then the mother liquor was decanted. The precipitate was re dissolved in dichloromethane, dried over sodium sulfate and purified on a 3 em silica gel pad eluted with hexanes: ethyl acetate mixture gradient (4:1 to 2:1) to afford the title product (0.73 g, 51%) as colorless powder.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111196-81-7, its application will become more common.

Reference:
Patent; Peu Lama Na Perm Syutikeolseu In Keu .; Man Su-reu-ta-rek-su-ha-il; Cha Pi-beu-mi-ka-il; Yu Din-mi-ka-il; Ge Jen-cheu-be-i-yu-ri; Ni Ki-tin-al-rek-san-deu-reu; (190 pag.)KR2019/15535; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 111196-81-7, 2-Chloro-5-ethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Chloro-5-ethylpyrimidine, blongs to pyrimidines compound. Safety of 2-Chloro-5-ethylpyrimidine

Piperidinemethanol (10.7 g, 93 mmol) is dissolved in DMA (60 niL), treated with 2-chloro-5-ethylpyrimidine (14.57 g, 102 mmol) and K2CO3 (19.3 g, 140 mmol) and heated to 130C overnight. The solid is filtered, washed with DMA and discarded. The filtrate is evaporated and the crude purified by flash chromatography (EtOAc/hexanes gradient) to afford (l-(5-ethylpyrimidin-2-yl)piperidin-4-yl)methanol Ala as yellow oil: 1H-NMR (400 MHz, CDCl3) delta = 8.16 (s, 2H), 4.75-4.72 (m, 2H), 3.53 (d, J = 6.0 Hz, 2H), 2.91-2.83 (m, 2H), 2.45 (q, J = 7.6 Hz, 2H), 1.84-1.73 (m, 3H), 1.27- 1.20 (m, 2H), 1.18 (t, J = 7.6 Hz, 3H); MS calcd. for [M+H]+ C12H20N3O: 222.1, found: 222.1.

The synthetic route of 111196-81-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IRM LLC; EPPLE, Robert; LELAIS, Gerald; NIKULIN, Victor; WESTSCOTT-BAKER, Lucas; WO2010/6191; (2010); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 111196-81-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111196-81-7, name is 2-Chloro-5-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

3-[(5-Ethyl-pyrimidin-2-yl)-(4-trifluoromethoxy-benzyl)-amino]-propan-1-ol: A solution of 3-(4-trifluoromethoxy-benzylamino)-propan-1-ol (3.1 g, 12.4 mmol), 2-chloro-5-ethylpyrimidine (1.51 mL, 12.4 mmol) and K2CO3 (2.6 g, 18.7 mmol) in DMF (50 mL) was heated to 165 C. overnight in a sealed tube. After cooling to room temperature, the mixture was diluted with ethyl acetate (100 mL) and then washed with water, brine and dried over Na2SO4. After removal of solvent, the residue was purified by silica gel chromatography to give 2.15 g (49%) of the desired product as a colorless solid. 1H NMR (400 MHz, CDCl3) delta 8.18 (s, 2H), 7.26 (d, 2H), 7.13 (d, 2H), 4.83 (s, 2H), 3.71 (t, 2H), 3.52 (t, 2H), 2.48 (q, 2H), 1.73 (m, 2H), 1.20 (t, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111196-81-7, 2-Chloro-5-ethylpyrimidine.

Reference:
Patent; KALYPSYS, INC; US2007/219193; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 111196-81-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 111196-81-7 as follows.

Step 1: l-(5-ethylpyrimidin-2-yl)piperidin To a solution of piperidin-4-ol (2.55 g, 25.2 mmol) in MeCN (50 mL) was added 2-chloro-5-ethylpyrimidine (3.00 g, 21.0 mmol), followed by N-ethyl-N-isopropylpropan-2-amine (7 mL, 42.0 mmol) and the resulting reaction mixture was heated to 80C for 16 hrs. The mixture was diluted with water, extracted with EtOAc, washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified with column chromatography (CH2C12: EtOAc = 3:1 to 1:1) to afford the desired product (3.69 g, 85%) as a yellow solid.1H NMR (CDC13): delta 8.16 (2H, s), 4.37-4.42 (2H, m), 3.92-3.94 (1H, m), 3.24-3.30 (2H, m), 2.45 (2H, q, / = 7.6 Hz), 1.92-1.98(2H, m), 1.69 (1H, brs), 1.48-1.53 (2H, m), 1.19 (3H, t, / = 7.6 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111196-81-7, its application will become more common.

Reference:
Patent; CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Yan; HU, Yuandong; WANG, Huting; LIU, Yuliang; LI, Jijun; SUN, Deguang; WANG, Zhe; WEI, Yongheng; WANG, Zanping; TANG, Guojing; JING, Lutao; WO2012/103806; (2012); A1;,
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Pyrimidine – Wikipedia

Synthetic Route of 111196-81-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 111196-81-7, name is 2-Chloro-5-ethylpyrimidine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 17a-f (7.78 mmol), 1-Boc-piperazine 13(7.78 mmol) in anhydrous ethanol (10 mL)was added triethylamine(15.56 mmol). The mixture was heated to reflux for 12 h. Aftercooling to the ambient temperature, ice-cold water (20 mL) wasadded. The precipitate was separated by filtration, washed withwater (10 mL) and dried to afford 18a-f. The compounds 18a-f wereused to the next step without further purification.

According to the analysis of related databases, 111196-81-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gong, Ningbo; Huan, Yi; Huang, Haihong; Jiang, Qian; Lei, Lei; Li, Gang; Li, Yan; Lu, Yang; Ma, Chen; Meng, Bingxu; Shen, Zhufang; Sheng, Li; Wang, Weiping; Yuan, Baokun; Zhou, Tian; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Pyrimidine | C4H4N2 – PubChem,
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