Category: 115617-41-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine, molecular formula is C6H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H6Cl2N2

5-Chloro-4-(3,3-diethyl-1,5-dioxaspiro[5.5]undec-9-yloxy)-6-ethylpyrimidine 2.0 g (8.8 mmol) of 3,3-diethyl-1,5-dioxaspiro[5.5]-undecan-9-ol were added to a suspension of 0.80 g (13.2 mmol) of sodium hydride (80%) in 20 ml of dry THF under a nitrogen atmosphere and the mixture was refluxed for 2 hours until deprotonation was complete. The reaction solution was then allowed to cool to approximately 35 C., and 1.60 g (8.9 mmol) of 4,5-dichloro-6-ethylpyrimidine dissolved in 3 ml of dry THF were added rapidly, and the reaction mixture was refluxed until the reaction was complete (approximately 2 hours, TLC check). After the reaction mixture had cooled to room temperature, 3 ml of isopropanol were added to destroy excess sodium hydride, the mixture was stirred for a further 15 minutes and poured into a mixture of in each case 100 ml of ether and saturated aqueous ammonium chloride solution. The aqueous phase was extracted thoroughly using ether, and the combined organic phases were dried over magnesium sulfate and subsequently concentrated in vacuo. Silica gel chromatography (petroleum ether/ethyl acetate 3:2) gave 2.0 g (60.3% of theory) of a colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 115617-41-9.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5859009; (1999); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 115617-41-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115617-41-9 as follows.

(2) Synthesis of dl-5-chloro-6-ethyl-4-(alpha-methyl-4-methylthiobenzylamino)pyrimidine (Compound No. 62) 2 g (3.3 mmol) of 4,5-dichloro-6-ethylpyrimidine which is a material compound (IIc), 1.9 g (11 mmol) of dl-alpha-methyl-4-methylthiobenzylamine which is a material compound (IIId), 2 ml of triethylamine and a catalytic amount of 4-(N,N-dimethylamino)pyridine were dissolved in 10 ml of N,N-dimethylformamide and the solution was heated under reflux for 8 hours. After the reaction, extraction with toluene and washing with water were conducted, followed by drying over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the resulting oily product was purified by silicagel column chromatography (Wako gel C-200, eluted with toluene:ethyl acetate = 4:1). The resultant was crystallized with hexane to give 1.8 g of the desired compound as colorless crystals (indicated in Table 19 as Compound No. 62).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115617-41-9, its application will become more common.

Reference:
Patent; UBE INDUSTRIES, LTD.; EP424125; (1991); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 115617-41-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 1 Preparation of d,l-4-[1′-(beta-naphthyl)-ethylamino]-5-chloro-6-ethylpyrimidine of the formula STR22 11.98 g of 1-(beta-naphthyl)-1-aminoethane and 20 ml of triethylamine are added to a solution of 12.39 g of 4,5-dichloro-6-ethylpyrimidine in 150 ml of n-butanol. The mixture is boiled under reflux for 12 hours. After concentration of the reaction solution by evaporation, the crude product is dissolved in 20 ml of chloroform, 6 ml of concentrated hydrochloric acid are added, and the product is extracted by shaking with water. The organic phase is separated off and dried with sodium sulfate and the solvent is distilled off, yielding a light-brown oil. The oil is triturated with hexane, whereupon the desired end product crystallises out. Filtration yields 11.6 g of substance; m.p.: 80-81 C. The resulting racemate can be separated into a (+)-enantiomer and its biologically more active (-)-enantiomer by fractional crystallisation with, for example, optically active tartaric acid, or can be resolved by separation on a chiral column by means of HPLC.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115617-41-9, 4,5-Dichloro-6-ethylpyrimidine.

Reference:
Patent; Ciba-Geigy Corporation; US5468751; (1995); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine, molecular formula is C6H6Cl2N2, molecular weight is 177.03, as common compound, the synthetic route is as follows.Recommanded Product: 115617-41-9

EXAMPLE 7 5-Chloro-6-ethyl-4-[cis-4-(isopropenyl)cyclohexylamino]pyrimidine (alternative synthesis) 1.6 g (0.009 mol) of 4,5-dichloro-6-ethylpyrimidine and 1.2 g (0.009 mol) of 4-isopropenylcyclohexylamine were stirred with 1.8 g (0.013 mol) of K2 CO3 in 10 ml of DMF at 80 C. for 6 hours. After cooling to room temperature, the mixture was placed in water and extracted with ether. The organic phase was washed with water, dried and filtered, and the filtrate was chromatographed on silica gel with petroleum ether/ethyl acetate 7:3 in order to separate the cis/trans isomers. The cis-cyclohexylamino derivative is eluted first (1.4 g, yellow oil) followed by the trans-cyclohexylamino derivative (0.6 g, yellow oil).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,115617-41-9, 4,5-Dichloro-6-ethylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Hoechst-Schering AgrEvo GmbH; US5889012; (1999); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine, molecular formula is C6H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 4,5-Dichloro-6-ethylpyrimidine

Step E 5-chloro-6-ethyl-N-[1-[4-(trimethylsilyl)phenyl]ethyl]-4-pyrimidinamine The product of Step D (17 g, 86 mole), 4,5-dichloro-6-ethylpyrimidine (15 g, 86 mole) and triethylamine (24 mL, 170 mole) were dissolved in toluene (65 mL). The reaction mixture was heated to reflux overnight and then cooled. Ether and water were added and the mixture was partitioned. The aqueous phase was extracted two times with ether and the combined organic phases were dried (MgSO4) and concentrated. The resultant solid was recrystallized from acetonitrile to give the title compound as a white solid (17 g, 60% yield), mp 79-80 C. 1 H NMR (CDCl3): delta 8.40 (s, 1H), 7.51, 7.36 (ABq, 4H), 5.60 (brd, 1H), 5.37 (q, 1H), 2.78 (q, 2H), 1.60 (d, 3H), 1.25 (t, 3H), 0.26 (s, 9H).

With the rapid development of chemical substances, we look forward to future research findings about 115617-41-9.

Reference:
Patent; E. I. Du Pont de Nemours and Company; US5378708; (1995); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 115617-41-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

5-Chloro-6-ethyl-4-(1,4-dioxaspiro[4,5]dec-8-yloxy)pyrimidine STR27 5 g (0.16 mol) of 80% sodium hydride are added to a solution of 19 g (0.12 mol) of 4-hydroxycyclohexanone ethylene acetal in 200 ml of absolute THF and the mixture is refluxed for 1 hour. The reaction solution is then cooled to room temperature and 21.2 g (0.12 mol) of 4,5-dichloro-6-ethylpyrimidine are added dropwise. The reaction mixture is refluxed for a further 2 hours. To destroy excess sodium hydride, 20 ml of isopropanol are slowly added dropwise, and the reaction mixture, which is still warm, is stirred for a further 30 minutes. 100 ml of aqueous ammonium chloride solution are subsequently added, the aqueous phase is extracted using ether, and the combined organic phases are dried over magnesium sulfate. The solvent is concentrated in vacuo to dryness. This gives 35.0 g (93%) of a yellow oil. The crude product can be reacted further without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115617-41-9, 4,5-Dichloro-6-ethylpyrimidine.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5691321; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 115617-41-9, 4,5-Dichloro-6-ethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 115617-41-9, blongs to pyrimidines compound. COA of Formula: C6H6Cl2N2

(1) Synthesis of 5-chloro-6-ethyl-4-[alpha-(2,2,3-trifluorobenzo-1,4-dioxane-6-yl) ethylamino] pyrimidine 0.7 g (4.0 mmol) of 4,5-dichloro-6-ethylpyrimidine which is a material compound (IIb), 0.8 g (3.4 mmol) of 1-(2,2,3-trifluorobenzo-1,4-dioxane-6-yl)ethylamine which is a material compound (IIIc) and a catalytic amount of 4-(N,N-dimethylamino)pyridine were suspended in 5 ml of triethylamine and the suspension was heated under reflux for 5 hours. After the reaction, extraction with toluene and washing with water were conducted. After drying with anhydrous sodium sulfate, toluene was removed by evaporation under reduced pressure. The resulting oily product was purified by silicagel column chromatography (Wako gel C-200, eluted with toluene:ethyl acetate = 5:1) to give 0.5 g of the desired compound as colorless oily product (indicated in Table 12 as Compound No. 41).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115617-41-9, its application will become more common.

Reference:
Patent; UBE INDUSTRIES, LTD.; EP424125; (1991); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 115617-41-9, 4,5-Dichloro-6-ethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 115617-41-9, blongs to pyrimidines compound. COA of Formula: C6H6Cl2N2

(1) Synthesis of 5-chloro-6-ethyl-4-[alpha-(2,2,3-trifluorobenzo-1,4-dioxane-6-yl) ethylamino] pyrimidine 0.7 g (4.0 mmol) of 4,5-dichloro-6-ethylpyrimidine which is a material compound (IIb), 0.8 g (3.4 mmol) of 1-(2,2,3-trifluorobenzo-1,4-dioxane-6-yl)ethylamine which is a material compound (IIIc) and a catalytic amount of 4-(N,N-dimethylamino)pyridine were suspended in 5 ml of triethylamine and the suspension was heated under reflux for 5 hours. After the reaction, extraction with toluene and washing with water were conducted. After drying with anhydrous sodium sulfate, toluene was removed by evaporation under reduced pressure. The resulting oily product was purified by silicagel column chromatography (Wako gel C-200, eluted with toluene:ethyl acetate = 5:1) to give 0.5 g of the desired compound as colorless oily product (indicated in Table 12 as Compound No. 41).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115617-41-9, its application will become more common.

Reference:
Patent; UBE INDUSTRIES, LTD.; EP424125; (1991); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine, molecular formula is C6H6Cl2N2, molecular weight is 177.03, as common compound, the synthetic route is as follows.Formula: C6H6Cl2N2

Example D 5-Chloro-6-ethyl-4-[cis-2-(4-methylphenyl)-1,3-dithian-5-ylamino]-pyrimidine 1.77 g (10 mmol) of 4,5-dichloro-6-ethyl-pyrimidine and 2.2 g (10 mmol) of 5-amino-2-(4-methylphenyl)-1,3-dithian were stirred with 2.02 g of triethylamine at 80-90 C. for 6 hours. The mixture was taken up in water/methylene chloride and the organic phase was dried and concentrated. For purification, the residue was chromatographed over silica gel (eluding agent petroleum ether/ethyl acetate 4:1). This gave 1.0 g of colorless solid (27.3% of theory), melting point: 138-139 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,115617-41-9, 4,5-Dichloro-6-ethylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Hoechst Scering AgrEvo GmbH; US6281221; (2001); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia