Category: 115932-00-8

Synthetic Route of 115932-00-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115932-00-8, name is Ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate, molecular formula is C9H9N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of ethyl pyrazolo[l,5-a]pyrimidine-3-carboxylate (3.15 g, 16.4 mmol) in ethanol (50 mL) and water (40 mL) was added potassium hydroxide aqueous solution (2 M, 40 mL). The reaction mixture was stirred at 50 C for 2 h and cooled down to room temperature and then concentrated in vacuo. The resulting mixture was adjusted to pH = 2 with 1M hydrochloric acid aqueous solution, and white solid was appeared, then filtered to afford the product as a white solid (2.6 g, 97%).LC-MS (ESI, neg. ion) m/z: 162.1 [M-H] . H NMR (600 MHz, DMSO-Lambda): delta (ppm) 9.26 (dd, J= 7.0, 1.7 Hz, 1H), 8.80 (dd, J = 4.1, 1.7 Hz, 1H), 8.58 (s, 1H), 7.26 (dd, J= 7.0, 4.1 Hz, 1H).

According to the analysis of related databases, 115932-00-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; LI, Minxiong; LI, Xiaobo; WO2015/73267; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 115932-00-8 , The common heterocyclic compound, 115932-00-8, name is Ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate, molecular formula is C9H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of pyrazolo [1,5-a] pyrimidine-3-carboxylic acid ethyl ester (3.15 g, 16.4 mmol)In ethanol (50 mL) and water (40 mL)Aqueous potassium hydroxide (2M, 40 mL) was added,The resulting reaction was stirred at 50 C for 2 hours,Cool to room temperature and concentrate under reduced pressure. A 1 M aqueous solution of dilute hydrochloric acid was added to the resulting reaction mixture to adjust to pH = 2. A white solid appeared and was filtered. The filter cake was collected to give the title compound as a white solid (2.6 g, 97%).

The synthetic route of 115932-00-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; (88 pag.)CN104650092; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 115932-00-8, Adding some certain compound to certain chemical reactions, such as: 115932-00-8, name is Ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate,molecular formula is C9H9N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 115932-00-8.

To a solution of pyrazolo [1,5-a] pyrimidine-3-carboxylic acid ethyl ester (3.15 g, 16.4 mmol)In ethanol (50 mL) and water (40 mL)Aqueous potassium hydroxide (2M, 40 mL) was added,The resulting reaction was stirred at 50 C for 2 hours,Cool to room temperature and concentrate under reduced pressure. A 1 M aqueous solution of dilute hydrochloric acid was added to the resulting reaction mixture to adjust to pH = 2. A white solid appeared and was filtered. The filter cake was collected to give the title compound as a white solid (2.6 g, 97%).

According to the analysis of related databases, 115932-00-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; (88 pag.)CN104650092; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia