Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1161763-15-0, name is 4-Amino-6-bromo-2-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 4-Amino-6-bromo-2-methylpyrimidine
60% sodium hydride (12.0 g, 0.30 mol) was suspended in THF (300 mL) and cooled down to 0 C. 4-amino-6-bromo-2-methylpyrimidine (Compound 9) (18.7 g, 0.1 mol) was then added in batches and stirred for 30 min. After methyl 2-chlorothiazole-5-formate (Compound 10) (17.7 g, 0.1 mol) was added in batches, the reactants were heated and reacted by refluxing for 4 h, and then cooled down to room temperature for reaction overnight. When controlling the temperature between 0 C. and 5 C., hydrochloric acid (2N) was added for neutralization reaction. After adding keep heat and stirred to grow grains for 1 h. Filtrate and wash the cake with water, and then dry to give target Compound 11 (25.8 g, yield is 78.4%).[0177]Element analysis: C10H9BrN4O2S, Calculated: C, 36.49; H, 2.76; N, 17.02. Found: C, 36.51; H, 2.77; N, 16.99.[0178]1H-NMR (500 MHz, DMSO-d6): delta(ppm) 2.580 (s, 3H), 3.820 (s, 3H), 6.960 (S, 1H), 8.160 (s, 1H), 12.376 (s, 1H) (which disappeared after exchanging D2O)[0179]13C-NMR (500 MHz, DMSO-d6): delta(ppm) 25.700, 52.800, 104.161, 121.662, 146.010, 157.910, 159.124, 162.412, 162.949, 167.871.
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Reference:
Patent; Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang; US2013/30177; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia