The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 116436-03-4, name is 2,4-Diamino-6-ethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 116436-03-4
General procedure: A solution of 6-morpholinopyrimidine-2,4-diamine 1a (5.0 g, 25.6 mmol) and potassium thiocyanate (14.9 g, 0.15 mol) in DMF (120 ml) was heated at 65 C. Pyridine (4.14 ml, 51.2 mmol) was added and the solution cooled to 5 C. Bromine (1.31 ml, 25.6 mmol) was added slowly and the reaction mixture stirred for 2 h at 5-10 C. The reaction mixture was poured into ice-water (100 ml) and stirred for 1 h. The volatiles were removed under reduced pressure and the resulting solid was diluted with water, filtered and dried. The crude solid was purified by flash chromatography on silica gel (CH2Cl2/MeOH 30:1) to yield the title compound as white solid (3.61 g, 56%).
With the rapid development of chemical substances, we look forward to future research findings about 116436-03-4.
Reference:
Article; Jang, Mi-Yeon; Jonghe, Steven De; Segers, Kenneth; Anne, Jozef; Herdewijn, Piet; Bioorganic and Medicinal Chemistry; vol. 19; 1; (2011); p. 702 – 714;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia