Category: 118-70-7

Reference of 118-70-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 118-70-7, name is Pyrimidine-4,5,6-triamine, molecular formula is C4H7N5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 1 Preparation of 7-Amino[1,2,5]thiadiazolo[3,4-d]pyrimidine A flask was charged with 19.78 g. (0.15 mole) of 4,5,6-triaminopyrimidine and 163.0 g. (137 mole) of thionyl chloride and the mixture stirred at reflux for 18 hours. The dark orange reaction mixture was evaporated to dryness on the rotary evaporator and to the residue was added 500 ml. water and 40 ml. methanol. The resulting solution was adjusted to a pH of 7.5-8.0 with saturated sodium bicarbonate solution and heated to reflux. The hot mixture was filtered and the filtrate cooled to 0-5 C. in an ice-bath. The solid was collected by filtration, washed twice with 50 ml. ice water and twice with 50 ml. ether. The resulting tan product was dried in vacuo at 70 C. overnight to afford 18.2 g. (79%) of product. M.p. 247-249 C.; tlc on silica gel in chloroform-methanol (8:1) showed one spot at Rf =

According to the analysis of related databases, 118-70-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck & Co., Inc.; US4098787; (1978); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

118-70-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 118-70-7 as follows.

10 mL of formamide and 90 g of 4,5,6-triaminopyrimidine (Formula 6) were added to a 1000 mL reaction flask and heated to 140 to 150 C for 4 hours. The reaction was completed and cooled to a temperature of 25 to 15 C Crystallization, filtration, formamide rinsing, water elution, gray adipate crude, refined with water, activated carbon decolorization after 79.5g white crystalline powder adenine (Formula 1), yield 81.8%, HPLC 99.9%.

The chemical industry reduces the impact on the environment during synthesis 118-70-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Taizhou Xingming Pharmaceutical Co., Ltd.; Liu Yi; Zhao Wujie; (10 pag.)CN106749043; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia