1193-21-1 | Pyrimidines

Haaz, Eniko’s team published research in ACS Omega in 2022 | CAS: 1193-21-1

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Formula: C4H2Cl2N2

《Vapor-Liquid Equilibrium Study of the Monochlorobenzene-4,6-Dichloropyrimidine Binary System》 was written by Haaz, Eniko; Fozer, Daniel; Thangaraj, Ravikumar; Szori, Milan; Mizsey, Peter; Toth, Andras Jozsef. Formula: C4H2Cl2N2This research focused onvapor liquid equilibrium monochlorobenzene dichloropyrimidine binary system. The article conveys some information:

The number of newly synthesized and produced organic chems. has increased extremely quickly. However, the measurements of their phys. properties, including their vapor-liquid equilibrium (VLE) data, are time-consuming. It so happens that there is no phys. property data about a brand-new chem. Therefore, the importance of calculating their physicochem. properties has been playing a more and more important role. 4,6-Dichloropyrimidine (DCP) is also a relatively new mol. of high industrial importance with little existing data. Therefore, their measurements and the comparison with the calculated data are of paramount concern. DCP is a widespread heterocyclic moiety that is present in synthetic pharmacophores with biol. activities as well as in numerous natural products. Isobaric VLE for the binary system of 4,6-dichloropyrimidine and its main solvent monochlorobenzene (MCB) was measured using a vapor condensate and liquid circulation VLE apparatus for the first time in the literature. D. functional-based VLE was calculated using the COSMO-SAC protocol to verify the laboratory results. The COSMO-SAC calculation was found to be capable of representing the VLE data with high accuracy. Adequate agreement between the exptl. and calculated VLE data was acquired with a minimal deviation of 3.0 x 10-3, which allows for broader use of the results. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Formula: C4H2Cl2N2)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Zhang, Yiwen’s team published research in ACS Catalysis in 2021 | CAS: 1193-21-1

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Recommanded Product: 1193-21-1

Zhang, Yiwen; Zhang, Min; Han, Zhengbo; Huang, Shijun; Yuan, Daqiang; Su, Weiping published an article in 2021. The article was titled 《Atmosphere-Pressure Methane Oxidation to Methyl Trifluoroacetate Enabled by a Porous Organic Polymer-Supported Single-Site Palladium Catalyst》, and you may find the article in ACS Catalysis.Recommanded Product: 1193-21-1 The information in the text is summarized as follows:

The efficient conversion of methane into methanol at low temperature under low pressure remains a great challenge largely because of the inertness and poor solubility of methane. Herein, we report that a porous organic polymer-supported Pd catalyst, which was constructed via Friedel-Crafts type polymerization between 4,6-dichloropyrimidine and 1,3,5-tri-Ph benzene and subsequent metalation, enabled the conversion of methane to Me trifluoroacetate, a precursor to methanol, under atm. pressure (1 atm) at 80°C to afford a 51% yield relative to methane with a TON of 664 over 20 h. On increasing the pressure to 30 bar, this palladium catalyst offered a TON of 1276 for a run and could be reused for at least five runs without a notable loss of activity. The characterization of this Pd catalyst revealed its good affinity for methane uptake that would increase the concentration of methane in the local space around the Pd center and the homogeneous distribution of Pd2+ on support that would protect the catalytically active metal species, shedding light on the high catalytic activity of this Pd catalyst toward methane conversion. The experimental process involved the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1Recommanded Product: 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Achelle, Sylvain’s team published research in Molecules in 2019 | CAS: 1193-21-1

Application In Synthesis of 4,6-DichloropyrimidineIn 2019 ,《Carbazole- and triphenylamine-substituted pyrimidines: synthesis and photophysical properties》 was published in Molecules. The article was written by Achelle, Sylvain; Rodriguez-Lopez, Julian; Larbani, Massinissa; Plaza-Pedroche, Rodrigo; Robin-le Guen, Francoise. The article contains the following contents:

A series of pyrimidine derivatives bearing one, two or three triphenylamine/9-ethylcarbazole substituents has been synthesized by Suzuki cross-coupling reaction. All compounds showed absorption bands in the UV region and the emission of violet-blue light upon irradiation Protonation led to quenching of the fluorescence, although some derivatives remained luminescent with the appearance of a new red-shifted band in the spectra. Accurate control of the amount of acid enabled white photoluminescence to be obtained both in solution and in solid state. In addition to this study using 4,6-Dichloropyrimidine, there are many other studies that have used 4,6-Dichloropyrimidine(cas: 1193-21-1Application In Synthesis of 4,6-Dichloropyrimidine) was used in this study.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hyodo, Tadashi’s team published research in CrystEngComm in 2019 | CAS: 1193-21-1

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Reference of 4,6-Dichloropyrimidine

In 2019,CrystEngComm included an article by Hyodo, Tadashi; Kawahata, Masatoshi; Hikami, Yuya; Komatsu, Ai; Tominaga, Masahide; Yamaguchi, Kentaro. Reference of 4,6-Dichloropyrimidine. The article was titled 《Cycloalkanes and cycloalkenes in dispersive force oriented inclusion crystals by a functionalized acyclic host molecule》. The information in the text is summarized as follows:

A disubstituted adamantane derivative bearing chloropyrimidine units (1) was synthesized as an acyclic host mol. to construct guest-inclusion crystalline materials, and the mol. structures of these crystalline materials were determined by X-ray crystallog. anal. The crystallization of 1 and trans-decahydronaphthalene (a) in chloroform afforded co-crystal (1a) with 2 : 1 host : guest complexation stoichiometry. The guest mol. was accommodated within the cavity of the cyclic dimers of 1 built from Cl···π interactions between the chloropyrimidine units. These complexes were assembled into network structures through intermol. interactions. From the Hirshfeld surface anal. and the 2D fingerprint plot of a in co-crystal 1a, the maximum contribution is from the H···H contacts between 1 and a, indicating that the main driving force for the guest inclusion is dispersive force. Co-crystals containing cycloalkanes and cycloalkenes (b-f) and having the same stoichiometry were obtained under identical conditions. In all the co-crystals, the shapes and sizes of the cyclic dimers and the mol. networks were similar to those of crystal 1a, and the mol. structures of the guests were characterized. In addition to this study using 4,6-Dichloropyrimidine, there are many other studies that have used 4,6-Dichloropyrimidine(cas: 1193-21-1Reference of 4,6-Dichloropyrimidine) was used in this study.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Cheng, Wei’s team published research in Dyes and Pigments in 2020 | CAS: 1193-21-1

《Blue iridium(III) complexes with high internal quantum efficiency based on 4-(pyridin-3-yl)pyrimidine derivative and their electroluminescent properties》 was written by Cheng, Wei; Wang, Li-Ding; Zhou, Yue-Yue; Bian, Zu-Qiang; Tong, Bi-Hai; Liu, Zhi-Wei; Wang, Song. HPLC of Formula: 1193-21-1 And the article was included in Dyes and Pigments in 2020. The article conveys some information:

Three novel highly efficient blue bicyclometalated Ir(III) complexes (Ir1-Ir3) were designed and synthesized with 4-(2,6-difluoropyridin-3-yl)-6-mesitylpyrimidine as primary ligands. The alternation of ancillary ligands had precisely regulated their emitting peaks from sky-blue to deep-blue. These complexes exhibit unimodal emission with PLQYs >90% and lifetimes shorter than 1.1μs. These complexes also show good thermal stability with Td > 320°. The OLED using complex Ir3 as emitter in 13% exhibited a maximum luminous efficiency of 16.9 cd A-1 with a high EQE of 13.0%. The CIE coordinates of this device are (0.15, 0.16), which are close to the standard blue color region. The experimental process involved the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1HPLC of Formula: 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Krasnov, Victor P.’s team published research in Molecules in 2022 | CAS: 1193-21-1

Application of 1193-21-1In 2022 ,《Synthesis of Pyrimidine Conjugates with 4-(6-Amino-hexanoyl)-7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and Evaluation of Their Antiviral Activity》 appeared in Molecules. The author of the article were Krasnov, Victor P.; Musiyak, Vera V.; Levit, Galina L.; Gruzdev, Dmitry A.; Andronova, Valeriya L.; Galegov, Georgii A.; Orshanskaya, Iana R.; Sinegubova, Ekaterina O.; Zarubaev, Vladimir V.; Charushin, Valery N.. The article conveys some information:

A series of pyrimidine conjugates containing a fragment of racemic 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine and its (S)-enantiomer attached via a 6-aminohexanoyl fragment were synthesized by the reaction of nucleophilic substitution of chlorine in various chloropyrimidines. Enantiomeric purity of optically active derivatives was confirmed by chiral HPLC. Antiviral evaluation of the synthesized compounds has shown that the replacement of purine with a pyrimidine fragment leads to a decrease in the anti-herpesvirus activity compared to the lead compound, purine conjugate. The studied compounds did not exhibit significant activity against influenza A (H1N1) virus. After reading the article, we found that the author used 4,6-Dichloropyrimidine(cas: 1193-21-1Application of 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kharlamova, Alisa D.’s team published research in Molecules in 2021 | CAS: 1193-21-1

Kharlamova, Alisa D.; Abel, Anton S.; Averin, Alexei D.; Maloshitskaya, Olga A.; Roznyatovskiy, Vitaly A.; Savelyev, Evgenii N.; Orlinson, Boris S.; Novakov, Ivan A.; Beletskaya, Irina P. published an article in 2021. The article was titled 《Mono- and diamination of 4,6-dichloropyrimidine, 2,6-dichloropyrazine and 1,3-dichloroisoquinoline with adamantane-containing amines》, and you may find the article in Molecules.Related Products of 1193-21-1 The information in the text is summarized as follows:

N-heteroaryl substituted adamantane-containing amines, e.g., I were of substantial interest for their perspective antiviral and psychotherapeutic activities. Chlorine atom at alpha-position of N-heterocycles was substituted by amino group using convenient nucleophilic substitution reactions with a series of adamantylalkylamines. The prototropic equilibrium in these compounds was studied using NMR spectroscopy. The introduction of second amino substituent in 4-amino-6-chloropyrimidine, 2-amino-chloropyrazine and 1-amino-3-chloroisoquinoline was achieved using Pd(0) catalysis. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

AlNeyadi, Shaikha S.’s team published research in Molecules in 2020 | CAS: 1193-21-1

Application In Synthesis of 4,6-DichloropyrimidineIn 2020 ,《Controlled release of pyrimidine compound using polymeric coated ZIF-8 metal-organic framework as glucagon-like peptide-1 receptor agonist carrier》 appeared in Molecules. The author of the article were AlNeyadi, Shaikha S.; Amir, Naheed; Ghattas, Mohammad A.; Atatreh, Noor; Alketbi, Shaikha S.; Al Ajeil, Ruba; Adem, Abdu. The article conveys some information:

This work demonstrates synthetic strategies for the incorporation of a synthesized pyrimidine glucagon-like peptide-1 (GLP-1) agonist into alginate-coated ZIF-8. The prepared pyrimidine GLP-1 agonist used for the treatment of diabetes type II, was trapped inside polymer coated ZIF-8. The encapsulation of the GLP-1 agonist was confirmed by UV-visible and FT-IR spectroscopies. Furthermore, the release kinetics of GLP-1 agonist drug from alginate-coated ZIF-8 were investigated in phosphate-buffered saline at 37°C at pH 8 and 1.5. The alginate-coated ZIF-8 exhibited much faster drug release at basic pH than at pH 1.5, indicating the potential of the alginate-coated ZIF-8 system to overcome the fast degradation at acidic pH of the stomach and improve the drug’s activity. This study may open the way for the synthesis of new metal organic frameworks (MOFs) to enhance drug delivery systems. In the experimental materials used by the author, we found 4,6-Dichloropyrimidine(cas: 1193-21-1Application In Synthesis of 4,6-Dichloropyrimidine)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Singh, Manpreet’s team published research in Inorganic Chemistry in 2022 | CAS: 1193-21-1

《Selective and Multicyclic CO2 Adsorption with Visible Light-Driven Photodegradation of Organic Dyes in a Robust Metal-Organic Framework Embracing Heteroatom-Affixed Pores》 was written by Singh, Manpreet; Neogi, Subhadip. Quality Control of 4,6-DichloropyrimidineThis research focused onzinc MOF CSMCRI 16 preparation crystal structure adsorbent photocatalyst; carbon dioxide multicyclic selective adsorption; cationic organic dye photodegradation. The article conveys some information:

Pore environment modulation with polarizing groups is one of the essential prerequisites for selective carbon dioxide (CO2) adsorption in metal-organic frameworks (MOFs), wherein judicious installation of the photocatalytic feature can promise visible light-triggered degradation of toxic organic dye mols. However, astute amalgamation of both these attributes over a single MOF is rather rare, yet much anticipated in view of sustainable applications. Pore engineering is effectively harnessed in a Zn(II)-based three-dimensional (3D) MOF, CSMCRI-16 (CSMCRI = Central Salt and Marine Chems. Research Institute), through mixed-ligand assembly of a N-rich linker (L), 4,4′-oxybis(benzoic acid) (H2oba) ligand, and [Zn2(CO2)4N2] paddle-wheel secondary building units (SBUs). The noninterpenetrated structure contains unbound nitrogen and accessible oxygen atom-decorated porous channels and exhibits admirable stability in diverse organic solvents, open air, and at elevated temperatures The heteroatom-decorated porous channels facilitated excellent CO2 uptake in the activated MOF (16a) with high selectivity over N2 (CO2/N2: 155.3) at 273 K. The framework further exhibits reasonable CO2 affinity and multicyclic CO2 sorption recurrence without a significant loss in the uptake capacity. Benefitting from the presence of the [Zn2(CO2)4N2] cluster in conjugation with π-conjugated organic ligands, the extended 3D network revealed an optical band gap energy of 2.55 eV, which makes the MOF an efficient photocatalyst toward the degradation of the cationic dyes crystal violet (CV) and methylene blue (MB) in the presence of a simple 40 W visible light lamp without any assistance of external oxidants. The catalyst exhibits multicyclic performance and short reaction time in addition to the fact that catalytic efficiencies (CV: 97.2%, MB: 97.8%) are comparable to those of contemporary materials. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1Quality Control of 4,6-Dichloropyrimidine)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Serevicius, Tomas’s team published research in Organic Electronics in 2020 | CAS: 1193-21-1

《Achieving efficient deep-blue TADF in carbazole-pyrimidine compounds》 was published in Organic Electronics in 2020. These research results belong to Serevicius, Tomas; Skaisgiris, Rokas; Fiodorova, Irina; Steckis, Vytautas; Dodonova, Jelena; Banevicius, Dovydas; Kazlauskas, Karolis; Jursenas, Saulius; Tumkevicius, Sigitas. COA of Formula: C4H2Cl2N2 The article mentions the following:

An approach for achieving deep blue thermally activated delayed fluorescence (TADF) is presented. A simple carbazole-pyrimidine compound Cbz-PYR with near-UV emission and simultaneous room-temperature phosphorescence (RTP) was selectively modified by lowering the singlet state energy, simultaneously preserving high triplet energy. The modified compound tCbz-mPYRs was shown to be efficient TADF emitter with 0.5 solid-state emission yield and peak wavelength of 428 nm. When used in OLED device, tCbz-mPYRs based OLED showed electroluminescence with 8.7% external quantum efficiency (EQE) and Commission Internationale de l′Eclairage (CIE) coordinates of (0.16; 0.12). In the part of experimental materials, we found many familiar compounds, such as 4,6-Dichloropyrimidine(cas: 1193-21-1COA of Formula: C4H2Cl2N2)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia