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Fang, Fang’s team published research in ACS Applied Bio Materials in 2020 | CAS: 1193-21-1

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Computed Properties of C4H2Cl2N2

《Europium-Doped Nanoparticles for Cellular Luminescence Lifetime Imaging via Multiple Manipulations of Aggregation State》 was written by Fang, Fang; Zhao, Dongxu; Zhang, Yinfeng; Li, Min; Ye, Jun; Zhang, Jinfeng. Computed Properties of C4H2Cl2N2 And the article was included in ACS Applied Bio Materials in 2020. The article conveys some information:

Luminescence lifetime imaging (LLIM) holds great promise in biomedical research owing to its excellent sensitivity and remarkable temporal-spatial resolution, but the development of effective long-lived luminescent probes for LLIM remains an unmet need. Herein, we designed two water-dispersible europium-doped nanoparticles (Eu-D1 and Eu-D2 NPs) for cellular LLIM, showing intense red luminescence emission and an increased lifetime of 4 orders of magnitude (~56 000 times) than undoped NPs, which could be attributed to the multiple manipulations of their aggregation states, including efficient Förster resonance energy transfer (FRET), suppressed self-quenching, and restrained solvent effects. With good bioavailability, the as-developed NPs were demonstrated as reliable candidates for long-lifetime imaging agents. Such a simple and versatile strategy could be extended to develop various luminescent nanoprobes for advanced high-precision bioimaging. After reading the article, we found that the author used 4,6-Dichloropyrimidine(cas: 1193-21-1Computed Properties of C4H2Cl2N2)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Xi, Sun-Chang’s team published research in European Polymer Journal in 2021 | CAS: 1193-21-1

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Application of 1193-21-1

Xi, Sun-Chang; Guo, Hao-Nan; Yang, Chang-Yuan; Wang, Ren; Wang, Dong-Yue; Dong, Bin published their research in European Polymer Journal in 2021. The article was titled 《A bisimidazolium-based cationic covalent triazine framework for CO2 capture and dye adsorption》.Application of 1193-21-1 The article contains the following contents:

In this work, an aromatic nitrile containing the pyrimidine moiety and bisimidazolium cations (PyImCl) was synthesized and subsequently employed to prepare a bisimidazolium-based cationic covalent triazine framework (PyImCl-cCTF) through the ionothermal trimerization reaction. The chem. composition and structure of PyImCl-cCTF were carefully revealed by a series of techniques. As examined by N2 sorption isotherms at 77 K, PyImCl-cCTF exhibited large surface area and abundant microporous structures. Together with the high content of imidazolium cations derived from the bisimidazolium-based monomer, PyImCl-cCTF showed high CO2 uptake capacity of 235 and 133 mg/g at 1 bar under 273 and 298 K, resp., superior to the previously reported cCTFs. The dye adsorption performance of PyImCl-cCTF was performed for commonly used dyes. Surprisingly, PyImCl-cCTF exhibited a certain removal effect on both anionic and cationic dyes. Moreover, PyImCl-cCTF with the pos. charged skeleton can quickly remove anionic dyes through electrostatic interactions, showing almost 100% removal efficiency within 20 min. These results demonstrate that PyImCl-cCTF can behave as an efficient adsorbent for both CO2 capture and dye removal to solve environmental problems.4,6-Dichloropyrimidine(cas: 1193-21-1Application of 1193-21-1) was used in this study.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Yang, Chao’s team published research in Journal of Organic Chemistry in 2020 | CAS: 1193-21-1

《Synthesis, Photophysical Properties, and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides》 was written by Yang, Chao; Pohl, Radek; Tichy, Michal; Gurska, Sona; Pavlis, Petr; Dzubak, Petr; Hajduch, Marian; Hocek, Michal. Related Products of 1193-21-1 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Two isomeric series of benzothieno-fused 7-deazapurine (benzo[4′,5′]thieno[3′,2′:4,5]- and benzo[4′,5′]thieno[2′,3′:4,5]pyrrolo[2,3-d]pyrimidine) ribonucleosides were designed and synthesized. Key steps of the synthesis included the Negishi coupling of zincated dichloropyrimidine with 2- or 3-iodobenzothiophene followed by azidation, thermal or photochem. cyclization, glycosylation, and final functionalization at position 6 through cross-couplings or nucleophilic substitutions. Deprotection gave the final nucleosides, some of which showed moderate cytotoxic and antiviral activity. Most of the free nucleosides showed moderate to strong fluorescence with emission maxima of 362-554 nm. 2′-Deoxyribonucleoside and its 5′-O-triphosphate were also prepared from benzothieno-fused 7-deazaadenine derivative, and the triphosphate was a good substrate for KOD XL DNA polymerase in primer extension synthesis of modified DNA which exerted a weak fluorescence which was slightly enhanced in double-stranded DNA as compared to single-stranded oligonucleotides. The results came from multiple reactions, including the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

AlNeyadi, Shaikha S.’s team published research in Results in Chemistry in 2021 | CAS: 1193-21-1

AlNeyadi, Shaikha S.; Adem, Abdu; Amer, Naheed; Ghattas, Mohammad A.; Atatreh, Noor; Salem, Alaa A.; Abdou, Ibrahim M. published their research in Results in Chemistry in 2021. The article was titled 《Activation of the GLP-1 receptor by chloropyrimidine derivatives》.COA of Formula: C4H2Cl2N2 The article contains the following contents:

The anti-diabetic activities of a series of chloropyrimidine derviativeswere investigated after they were designed, synthesized, and docked against the GLP-1 receptor target. In comparison to exenatide, which was utilized as a reference drug, the three chloropyrimidine synthesized compounds I, II and III exhibited potent in vitro and in vivo antidiabetic activities. Interestingly, compounds I, II and III showed to be the most effective in lowering blood glucose levels and led to even higher glucose uptake than the reference drug, exenatide. Consistent with the in vitro and in vivo data, compounds II and III had the lowest docking energy scores (Glide-XP score = 5.1 kcal/mol) and the greatest ligand efficiency score (> – 0.40 kcal/mol) among all docked compounds These findings give up new possibilities for the development of high-efficacy compounds to treat hyperglycemia. The experimental process involved the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1COA of Formula: C4H2Cl2N2)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Skaisgiris, Rokas’s team published research in Journal of Luminescence in 2022 | CAS: 1193-21-1

In 2022,Skaisgiris, Rokas; Serevicius, Tomas; Dodonova, Jelena; Banevicius, Dovydas; Kazlauskas, Karolis; Tumkevicius, Sigitas; Jursenas, Saulius published an article in Journal of Luminescence. The title of the article was 《Tuning of HOMO-LUMO localization for achieving thermally activated delayed fluorescence》.Safety of 4,6-Dichloropyrimidine The author mentioned the following in the article:

High emission yield and rapid reverse intersystem crossing are essential for efficient thermally activated delayed fluorescence (TADF) compounds In this paper, we show that efficient TADF can be achieved by enhancing the localization of HOMO and LUMO in carbazole-pyrimidine compounds with rather flat mol. structure. Simple carbazole-pyrimidine Cbz-PYR was selected as a reference compound due to the pronounced room-temperature phosphorescence activity. The subsequent modifications of carbazole and pyrimidine units with diphenylamine and Ph fragments resulted in weakened HOMO-LUMO communication, leading to the minimized singlet-triplet energy gap of only 111 meV. Due to the rather flat mol. geometry, TADF compounds showed remarkable radiative decay rate reaching 4.6 x 107 s-1 for the most efficient TADF-active carbazole-pyrimidine compound dCbz-pPYR, followed by high emission yield of 0.75. Efficient green electroluminescence with peak EQE of 18.3%. was shown for OLED device with dCbz-pPYR emitter. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Safety of 4,6-Dichloropyrimidine)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Zhang, Chufeng’s team published research in Journal of Medicinal Chemistry in 2021 | CAS: 1193-21-1

Zhang, Chufeng; Qi, Wenyan; Li, Yong; Tang, Minghai; Yang, Tao; Liu, Kongjun; Chen, Yong; Deng, Dexin; Xiang, Mingli; Chen, Lijuan published an article in 2021. The article was titled 《Discovery of 3-(4-(2-((1H-Indol-5-yl)amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease》, and you may find the article in Journal of Medicinal Chemistry.Recommanded Product: 1193-21-1 The information in the text is summarized as follows:

The design, synthesis, and structure-activity relationships (SARs) of 3-(4-(2-((1H-indol-5-yl)amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile I [R5= 2-cyanoethyl; R6 = Me, fluoro; R7 = indolin-5-yl, 1-oxoisoindolin-5-yl, 1-tert-butoxycarbonylindol-5-yl, etc.] as selective TYK2 inhibitors was reported. Among them, compound I [R5 = 2-cyanoethyl; R6 = fluoro; R7 = 1-tert-butoxycarbonylindol-5-yl] exhibited acceptable TYK2 inhibition with an IC50 value of 9 nM, showed satisfactory selectivity characteristics over the other three homologous JAK kinases, and performed good functional potency in the JAK/STAT signaling pathway on lymphocyte lines and human whole blood. In liver microsomal assay studied that the clearance rate and half-life of I [R5 = 2-cyanoethyl; R6 = fluoro; R7 = 1-tert-butoxycarbonylindol-5-yl] were 11.4 mL/min/g and 121.6 min, resp. Furthermore, in a dextran sulfate sodium colitis model, I [R5 = 2-cyanoethyl; R6 = fluoro; R7 = 1-tert-butoxycarbonylindol-5-yl] reduced the production of pro-inflammatory cytokines IL-6 and TNF-α and improved the inflammation symptoms of mucosal infiltration, thickening, and edema. Compound I [R5 = 2-cyanoethyl; R6 = fluoro; R7 = 1-tert-butoxycarbonylindol-5-yl] was aselective TYK2 inhibitor and was used to treat immune diseases and deserved further investigation. In the part of experimental materials, we found many familiar compounds, such as 4,6-Dichloropyrimidine(cas: 1193-21-1Recommanded Product: 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Noda, Hidetoshi’s team published research in Chemistry – A European Journal in 2019 | CAS: 1193-21-1

In 2019,Chemistry – A European Journal included an article by Noda, Hidetoshi; Asada, Yasuko; Maruyama, Tatsuro; Takizawa, Naoki; Noda, Nobuo N.; Shibasaki, Masakatsu; Kumagai, Naoya. Reference of 4,6-Dichloropyrimidine. The article was titled 《A C4N4 Diaminopyrimidine Fluorophore》. The information in the text is summarized as follows:

A new scaffold for producing efficient organic fluorescent materials was identified: 2,5-diamino-4,6-diarylpyrimidine featuring a C4N4 elemental composition Single-step installation of two aryl groups at the 4,6-positions of the pyrimidine core delivered fluorescent organic materials in a modular fashion. A range of fluorescent compounds with distinct absorption/emission properties was readily accessed by changing the aromatic attachments. A generally high absorption coefficient and quantum yield were observed, including C4N4 derivatives that could fluoresce even in the solid state. The two amino groups at the 2,5-positions of the pyrimidine were essential for intense fluorescence with a large Stokes shift, which was corroborated by structural relaxation to a p-iminoquinone-like structure in the excited state. Besides live-cell imaging capabilities, fluorescent labeling of a protein involved in autophagy elucidated a new protein-protein interaction, supporting potential utility in bioimaging applications. The experimental process involved the reaction of 4,6-Dichloropyrimidine(cas: 1193-21-1Reference of 4,6-Dichloropyrimidine)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wu, Tsung-Sheng’s team published research in Journal of Medicinal Chemistry in 2019 | CAS: 1193-21-1

In 2019,Journal of Medicinal Chemistry included an article by Wu, Tsung-Sheng; Lin, Wen-Hsing; Tsai, Hui-Jen; Hsueh, Ching-Cheng; Hsu, Tsu; Wang, Pei-Chen; Lin, Hui-You; Peng, Yi-Hui; Lu, Cheng-Tai; Lee, Lung-Chun; Tu, Chih-Hsiang; Kung, Fang-Chun; Shiao, Hui-Yi; Yeh, Teng-Kuang; Song, Jen-Shin; Chang, Jia-Yu; Su, Yu-Chieh; Chen, Li-Tzong; Chen, Chiung-Tong; Jiaang, Weir-Torn; Wu, Su-Ying. Synthetic Route of C4H2Cl2N2. The article was titled 《Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants》. The information in the text is summarized as follows:

Drug resistance due to acquired mutations that constitutively activate c-KIT is a significant challenge in the treatment of patients with gastrointestinal stromal tumors (GISTs). Herein, we identified 1-(5-ethyl-isoxazol-3-yl)-3-(4-{2-[6-(4-ethylpiperazin-1-yl)pyrimidin-4-ylamino]-thiazol-5-yl}phenyl)urea (10a) as a potent inhibitor against unactivated and activated c-KIT. The binding of 10a induced rearrangements of the DFG motif, αC-helix, juxtamembrane domain, and the activation loop to switch the activated c-KIT back to its structurally inactive state. To the best of our knowledge, it is the first structural evidence demonstrating how a compound can inhibit the activated c-KIT by switching back to its inactive state through a sequence of conformational changes. Moreover, 10a can effectively inhibit various c-KIT mutants and the proliferation of several GIST cell lines. The distinct binding features and superior inhibitory potency of 10a, together with its excellent efficacy in the xenograft model, establish 10a as worthy of further clin. evaluation in the advanced GISTs.4,6-Dichloropyrimidine(cas: 1193-21-1Synthetic Route of C4H2Cl2N2) was used in this study.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Wei, Xia’s team published research in Macromolecular Chemistry and Physics in 2020 | CAS: 1193-21-1

Related Products of 1193-21-1In 2020 ,《Selectable and releasable noncovalent functionalization of semiconducting SWCNTs by biethynyl-2,5-bis(dodecoxy)benzene unit-containing conjugated copolymers》 appeared in Macromolecular Chemistry and Physics. The author of the article were Wei, Xia; Maimaitiyiming, Xieraili. The article conveys some information:

A rigid structural unit diethynyl-2,5-bis(dodecoxy)benzene (DDB) is proposed to functionalize single-walled carbon nanotubes (SWCNTs) with the assistance of pyrimidine ring. The effectiveness of conjugated polymer extraction of semiconducting SWCNTs is demonstrated by absorption and Raman spectroscopy. The protonated pyrimidine ring by the trifluoroacetic acid is used to reduce the interaction between polymer and SWCNTs that the bound wrapping polymer can be removed from the sorted SWCNTs, and mol. dynamics simulations of the binding ability of DDB and pyrimidine units to SWCNTs are conducted to further illustrate the strong binding ability of DDB units to SWCNTs. Therefore, this work provides an effective structural and theor. reference for polymer separation or modification of semiconducting SWCNTs. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pola, Suresh’s team published research in Bioorganic & Medicinal Chemistry in 2021 | CAS: 1193-21-1

Pola, Suresh; Shah, Shailesh R.; Pingali, Harikishore; Zaware, Pandurang; Thube, Baban; Makadia, Pankaj; Patel, Hoshang; Bandyopadhyay, Debdutta; Rath, Akshyaya; Giri, Suresh; Patel, Jitendra H.; Ranvir, R. K.; Sundar, S. R.; Patel, Harilal; Kumar, Jeevan; Jain, Mukul R. published an article in 2021. The article was titled 《Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes》, and you may find the article in Bioorganic & Medicinal Chemistry.COA of Formula: C4H2Cl2N2 The information in the text is summarized as follows:

Benzylidenethiazolidinedione as a novel polar head for discovering a new series of GPR119 agonists I [R = H, Me; R1 = methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl, isobutoxycarbonyl, benzyloxycarbonyl] was discussed. The identification of a potent and oral GPR 119 agonist II [R = Me; R1 = tert-butoxycarbonyl], which showed in-vitro potency in the cell-based assay and in-vivo efficacy without exerting any significant signs of toxicity in relevant animal models. In the experimental materials used by the author, we found 4,6-Dichloropyrimidine(cas: 1193-21-1COA of Formula: C4H2Cl2N2)

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia