Category: 1193-21-1

Kamaura, Masahiro; Kubo, Osamu; Sugimoto, Hiromichi; Noguchi, Naoyoshi; Miyashita, Hirohisa; Abe, Shinichi; Matsuda, Kae; Tsujihata, Yoshiyuki; Odani, Tomoyuki; Iwasaki, Shinji; Murata, Toshiki; Sato, Kenjiro published an article in 2021. The article was titled 《Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach》, and you may find the article in Bioorganic & Medicinal Chemistry.Product Details of 1193-21-1 The information in the text is summarized as follows:

We previously identified a novel series of indolinylpyrimidine derivatives exemplified by 2 in Figure 1, which is an indoline based derivative, as potent GPR119 agonists. Despite the attractive potency of 2, this compound inhibited the human ether-a-go-go-related gene (hERG) K+ channel. We elucidated crucial roles of the methylsulfonyl group of 2 in its interaction with the hERG channel and the GPR119 receptor, presumably as a hydrogen bond acceptor (HBA). To remove the undesirable hERG inhibitory activity, a strategy was implemented to arrange an HBA on a less conformationally flexible framework at the indoline 5-position instead of the methylsulfonyl group. This successfully led to the discovery of a piperidinone ring as a desirable motif at the indoline 5-position, which could minimize hERG liability as shown by 24b. Further optimization focused on the reduction of lipophilicity in terms of more favorable drug-like properties. Consequently, the introduction of a hydroxy group at the 3-position of the piperidinone ring effectively reduced lipophilicity without compromising GPR119 potency, resulting in the identification of (3S)-3-hydroxy-1-{1-[6-({1-[3-(propan-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}oxy)pyrimidin-4-yl]- 2,3-dihydro-1H-indol-5-yl}piperidin-2-one ((S)-29) as a novel, potent, and orally bioavailable GPR119 agonist with a well-balanced profile. The pharmacol. effects of this compound were also confirmed after single and chronic oral administration in diabetic animal models. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1Product Details of 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Recommanded Product: 1193-21-1In 2021 ,《Design, synthesis, and structure-activity relationships study of N-pyrimidyl/pyridyl-2-thiazolamine analogues as novel positive allosteric modulators of M3 muscarinic acetylcholine receptor》 appeared in Chemical & Pharmaceutical Bulletin. The author of the article were Tanaka, Hiroaki; Akaiwa, Michinori; Negoro, Kenji; Kawaminami, Eiji; Mihara, Hisashi; Fuji, Hideyoshi; Okimoto, Risa; Ino, Katsutoshi; Ishizu, Kenichiro; Takahashi, Taisuke. The article conveys some information:

The M3 muscarinic acetylcholine receptor (mAChR) plays an essential pharmacol. role in mediating a broad range of actions of acetylcholine (ACh) released throughout the periphery and central nerve system (CNS). Nevertheless, its agonistic functions remain unclear due to the lack of available subtype-selective agonists or pos. allosteric modulators (PAMs). Based on the extended structure-activity relationships (SARs) study on a previously reported PAM of the M3 mAChR, 2-acylaminothiazole I, aa series of N-azinyl-2-thiazolamine analogs II (X = pyridine-2,6-diyl, pyrimidine-2,4-diyl, 5-fluoropyrimidine-4,6-diyl, pyrazine-3,6-diyl, etc.) were identified as new scaffolds. The SARs study was rationalized using conformational analyses based on intramol. interactions. A comprehensive study of a series of analogs described in this paper suggests that a unique sulfur-nitrogen nonbonding interaction in the N-azinyl-2-thiazolamine moiety enables conformations that are essential for activity. Further, a SARs study around the N-pyrimidyl/pyridyl-2-thiazolamine core culminated in the discovery of the compound II (X = 5-fluoro-2-methylpyrimidine-4,6-diyl), which showed potent in vitro PAM activity for the M3 mAChR with excellent subtype selectivity. Compound II (X = 5-fluoro-2-methylpyrimidine-4,6-diyl) also showed a distinct pharmacol. effect on isolated smooth muscle tissue from rat bladder and favorable pharmacokinetics profiles, suggesting its potential as a chem. tool for probing the M3 mAChR in further research. In addition to this study using 4,6-Dichloropyrimidine, there are many other studies that have used 4,6-Dichloropyrimidine(cas: 1193-21-1Recommanded Product: 1193-21-1) was used in this study.

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 1193-21-1

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 4,6-DichloropyrimidineIn 2020 ,《Ruthenium, rhodium and iridium complexes containing pyrimidine based thienyl pyrazoles: Synthesis and antibacterial studies》 was published in Journal of Organometallic Chemistry. The article was written by Lapasam, Agreeda; Mawnai, Ibaniewkor L.; Banothu, Venkanna; Kaminsky, Werner; Kollipara, Mohan Rao. The article contains the following contents:

The reaction of pyrimidine based electron-rich heterocyclic thiophene pyrazoles and halide bridged arene d6 metal precursors yielded a series of mononuclear and dinuclear half sandwich d6 metal complexes. Mononuclear and dinuclear complexes formed by the ratio-based reaction between ligand and metal precursor. All these cationic complexes have been characterized by IR, UV-Vis, 1H NMR, 13C NMR spectroscopic techniques. Complex 5 has been established by single-crystal anal. X-ray diffraction studies revealed the formation of mononuclear and dinuclear complexes and suggest that the vicinity around the metal atom is distorted octahedral. An in vitro study to screen the antibacterial potential of these complexes against pathogenic bacteria, S. aureus, K. pneumoniae, and E. coli was addressed. All the complexes display a better zone of inhibitions for both Gram-pos. (S. aureus) and Gram-neg. strains (K. pneumoniae, and E. coli). The min. inhibitory concentrations (MICs) for the most active complex ranged from 0.125 to 0.25 mg/mL for S. aureus and Klebsiella Pneumoniae and 0.25-0.5 mg/mL for E. coli. The experimental part of the paper was very detailed, including the reaction process of 4,6-Dichloropyrimidine(cas: 1193-21-1Quality Control of 4,6-Dichloropyrimidine)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Quality Control of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1193-21-1In 2020 ,《Achieving Submicrosecond Thermally Activated Delayed Fluorescence Lifetime and Highly Efficient Electroluminescence by Fine-Tuning of the Phenoxazine-Pyrimidine Structure》 was published in ACS Applied Materials & Interfaces. The article was written by Serevicius, Tomas; Skaisgiris, Rokas; Dodonova, Jelena; Jagintavicius, Laimis; Banevicius, Dovydas; Kazlauskas, Karolis; Tumkevicius, Sigitas; Jursenas, Saulius. The article contains the following contents:

Thermally activated delayed fluorescence (TADF) materials, combining high fluorescence quantum efficiency and short delayed emission lifetime, are highly desirable for application in organic light-emitting diodes (OLEDs) with negligible external quantum efficiency (EQE) roll-off. Here, we present the pathway for shortening the TADF lifetime of highly emissive 4,6-bis[4-(10-phenoxazinyl)phenyl]pyrimidine derivatives Tiny manipulation of the mol. structure with Me groups was applied to tune the singlet-triplet energy-level scheme and the corresponding coupling strengths, enabling the boost of the reverse intersystem crossing (rISC) rate (from 0.7 to 6.5) × 106 s-1 and shorten the TADF lifetime down to only 800 ns in toluene solutions An almost identical TADF lifetime of roughly 860 ns was attained also in solid films for the compound with the most rapid TADF decay in toluene despite the presence of inevitable conformational disorder. Concomitantly, the boost of fluorescence quantum efficiency to near unity was achieved in solid films due to the weakened nonradiative decay. Exceptional EQE peak values of 26.3-29.1% together with adjustable emission wavelength in the range of 502-536 nm were achieved in TADF OLEDs. Reduction of EQE roll-off was demonstrated by lowering the TADF lifetime. In the experiment, the researchers used many compounds, for example, 4,6-Dichloropyrimidine(cas: 1193-21-1Related Products of 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Related Products of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2019,Journal of Organic Chemistry included an article by Perez-Caaveiro, Cristina; Oliva, Maria Moreno; Lopez Navarrete, Juan T.; Perez Sestelo, Jose; Martinez, M. Montserrat; Sarandeses, Luis A.. Application In Synthesis of 4,6-Dichloropyrimidine. The article was titled 《Synthesis of D-A-A and D-A-D Pyrimidine π-Systems Using Triorganoindium Reagents: Optical, Vibrational, and Electrochemical Studies》. The information in the text is summarized as follows:

A series of donor-acceptor-acceptor (D-A-A) and donor-acceptor-donor (D-A-D) systems based on a pyrimidine π-spacer with various substituents at the C-2 position has been successfully prepared The synthesis involved site-selective palladium cross-coupling reactions of chloropyrimidines with triorganoindium reagents and proceed in good yields and with atom economy. 4-(N,N-Diphenylamino)phenyl was chosen as the donor group and thien-2-yl dicyanovinylene as the acceptor one. The optical, vibrational, electrochem., and d. functional theory (DFT) calculations of these mol. systems were analyzed, and exptl. values show the important role of the substituents at the C-2 position of the pyrimidine with stronger electron accepting ability, absorption in a wide range of UV/vis, acceptable fluorescence lifetime, and effective intramol. charge transfer (ICT) properties. The ICT was observed in both series by the bathochromic shift on increasing the polarity of the solvent. In addition, DFT calculations found lower lowest unoccupied MOs of D-A-A mols. that suggest good electron ejection and transportation, being good properties for their application in various organic optoelectronic devices. After reading the article, we found that the author used 4,6-Dichloropyrimidine(cas: 1193-21-1Application In Synthesis of 4,6-Dichloropyrimidine)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Application In Synthesis of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Mycobacterium tuberculosis Decaprenylphosphoryl-β-D-ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity》 was written by Borthwick, Jennifer A.; Alemparte, Carlos; Wall, Ian; Whitehurst, Benjamin C.; Argyrou, Argyrides; Burley, Glenn; de Dios-Anton, Paco; Guijarro, Laura; Monteiro, Maria Candida; Ortega, Fatima; Suckling, Colin J.; Pichel, Julia Castro; Cacho, Monica; Young, Robert J.. Product Details of 1193-21-1 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:

Decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1) is an essential enzyme in Mycobacterium tuberculosis and has recently been studied as a potential drug target, with inhibitors progressing to clin. studies. Here we describe the identification of a novel series of morpholino-pyrimidine DprE1 inhibitors. These were derived from a phenotypic high-throughput screening (HTS) hit with suboptimal physicochem. properties. Optimization strategies included scaffold-hopping, synthesis, and evaluation of fragments of the lead compounds and property-focused optimization. The resulting optimized compounds had much improved physicochem. properties and maintained enzyme and cellular potency. These mols. demonstrated potent efficacy in an in vivo tuberculosis murine infection model. After reading the article, we found that the author used 4,6-Dichloropyrimidine(cas: 1193-21-1Product Details of 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Product Details of 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In 2019,ACS Applied Materials & Interfaces included an article by Shafikov, Marsel Z.; Daniels, Ruth; Pander, Piotr; Dias, Fernando B.; Williams, J. A. Gareth; Kozhevnikov, Valery N.. Application In Synthesis of 4,6-Dichloropyrimidine. The article was titled 《Dinuclear Design of a Pt(II) Complex Affording Highly Efficient Red Emission: Photophysical Properties and Application in Solution-Processible OLEDs》. The information in the text is summarized as follows:

The light-emitting efficiency of luminescent materials is invariably compromised on moving to the red and near-IR regions of the spectrum due to the transfer of electronic excited-state energy into vibrations. The authors describe how this undesirable energy gap law can be sidestepped for phosphorescent organometallic emitters through the design of a mol. emitter that incorporates two Pt(II) centers. The dinuclear cyclometalated complex of a substituted 4,6-bis(2-thienyl)pyrimidine emits very brightly in the red region of the spectrum (λmax = 610 nm, Φ = 0.85 in deoxygenated CH2Cl2 at 300 K). The lowest-energy absorption band is extraordinarily intense for a cyclometalated metal complex: at λ = 500 nm, ε = 53,800 M-1 cm-1. The very high efficiency of emission achieved can be traced to an unusually high rate constant for the T1 → S0 phosphorescence process, allowing it to compete effectively with nonradiative vibrational decay. The high radiative rate constant correlates with an unusually large zero-field splitting of the triplet state, which is 40 cm-1 by variable-temperature time-resolved spectroscopy over the range 1.7 < T < 120 K. The compound was successfully tested as a red phosphor in an organic light-emitting diode prepared by solution processing. The results highlight a potentially attractive way to develop highly efficient red and NIR-emitting devices through the use of multinuclear complexes. In the experimental materials used by the author, we found 4,6-Dichloropyrimidine(cas: 1193-21-1Application In Synthesis of 4,6-Dichloropyrimidine)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.Application In Synthesis of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Maimaitiyiming, Xieraili; Shi, Caijin published their research in Materials Chemistry and Physics in 2021. The article was titled 《Poly(1,4-diethynylphenylene-4,6-pyrimidine)s for fluorescence detection of mercury(II) ion》.Category: pyrimidines The article contains the following contents:

A series of alternating conjugated polymers (poly (1,4-diethynylphenylene-4,6-pyrimidine) (PI) and poly (2,5-diheptyloxy-1,4-diethynyl-phenylene-4,6-pyrimidine) (PII) were synthesized via Sonogashira coupled reaction. Chem. structure of conjugated polymers were certified by NMR and FT-IR. The PIII(poly(2,5-bis(dodecoxy)-1,4-diethynyl-phenylene-4,6-pyrimidine) previously reported by our group to illustrate the application of such polymer. The fluorescence of PIII were efficiently quenched when introduced I-, the specificity of the polymer for I- was verified by experiments and detection limit reaches 5.19 x 10-7 mol/L. Thanks to the high association constant between Hg2+ and I-, the fluorescence of PIII/I- system recovered with the addition of Hg2+. The detection limit of Hg2+ reaches ∼4.92 x 10-6 mol/L for PIII/I- complex system. PIII/I- could act as high selective, sensitive and anti-interference optical probe for Hg2+. In the part of experimental materials, we found many familiar compounds, such as 4,6-Dichloropyrimidine(cas: 1193-21-1Category: pyrimidines)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Category: pyrimidines

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《A short de novo synthesis of nucleoside analogs》 was written by Meanwell, Michael; Silverman, Steven M.; Lehmann, Johannes; Adluri, Bharanishashank; Wang, Yang; Cohen, Ryan; Campeau, Louis-Charles; Britton, Robert. HPLC of Formula: 1193-21-1 And the article was included in Science (Washington, DC, United States) in 2020. The article conveys some information:

Nucleoside analogs are commonly used in the treatment of cancer and viral infections. Their syntheses benefit from decades of research but are often protracted, unamenable to diversification, and reliant on a limited pool of chiral carbohydrate starting materials. We present a process for rapidly constructing nucleoside analogs from simple achiral materials. Using only proline catalysis, heteroaryl-substituted acetaldehydes are fluorinated and then directly engaged in enantioselective aldol reactions in a one-pot reaction. A subsequent intramol. fluoride displacement reaction provides a functionalized nucleoside analog. The versatility of this process is highlighted in multigram syntheses of D- or L-nucleoside analogs, locked nucleic acids, iminonucleosides, and C2′- and C4′-modified nucleoside analogs. This de novo synthesis creates opportunities for the preparation of diversity libraries and will support efforts in both drug discovery and development. In the experiment, the researchers used 4,6-Dichloropyrimidine(cas: 1193-21-1HPLC of Formula: 1193-21-1)

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.HPLC of Formula: 1193-21-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application In Synthesis of 4,6-DichloropyrimidineIn 2019 ,《Design, Synthesis, and Structure-Activity Relationship of New Arylpyrazole Pyrimidine Ether Derivatives as Fungicides》 appeared in Journal of Agricultural and Food Chemistry. The author of the article were Zhang, Pengfei; Guan, Aiying; Xia, Xiaoli; Sun, Xufeng; Wei, Siyuan; Yang, Jinlong; Wang, Junfeng; Li, Zhinian; Lan, Jie; Liu, Changling. The article conveys some information:

To explore a novel fungicide effectively against cucumber downy mildew (CDM), a series of new arylpyrazole containing pyrimidine ether derivatives were designed and synthesized by employing the intermediate derivatization method (IDM). The structures of synthesized compounds were identified by 1H NMR, 13C NMR, elemental analyses, MS, and X-ray diffraction. Bioassays demonstrated that some of the title compounds exhibited excellent fungicidal activities against CDM. Especially, compound I (EC50 = 1.22 mg/L) displayed significantly higher bioactivity than that of com. fungicides diflumetorim and flumorph and nearly equal effect to that of cyazofamid. The relationship between the structure and fungicidal activity of the synthesized compounds was discussed as well. The study showed that compound I was a promising fungicide candidate for further development. In addition to this study using 4,6-Dichloropyrimidine, there are many other studies that have used 4,6-Dichloropyrimidine(cas: 1193-21-1Application In Synthesis of 4,6-Dichloropyrimidine) was used in this study.

4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 4,6-Dichloropyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia