Category: 1193-21-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1193-21-1, name is 4,6-Dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dichloropyrimidine

4,6-Dichloropyrimidine (190 mg, 1.28 mmol, 1.0 equiv.),157 mg p-anisidine (1.27 mmol, 1.0 equiv.), and 180 mg N,N-diisopropylethylamine (1.39 mmol, 1.1 equiv.) were introduced into a Falcon tube, dissolved in NMP, and filled up to a volume of 12.7 cm3 with NMP. The solution was reacted according to general procedure A at 160 Cusing a 4 cm3 coil at a flow rate of 0.5 cm3/min. Crude product was purified as described for the batch synthesis giving pyrimidine 1 as a white, fluffy solid in 81 % yield (243 mg, 1.03 mmol).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1193-21-1, 4,6-Dichloropyrimidine.

Reference:
Article; Schoen, Michael; Dreier, Dominik; Schnuerch, Michael; Mihovilovic, Marko D.; Monatshefte fur Chemie; vol. 147; 3; (2016); p. 523 – 532;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1193-21-1, 4,6-Dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1193-21-1, blongs to pyrimidines compound. Recommanded Product: 1193-21-1

298 mL of methanol is added to 387 mL (7.98 mol) of hydrazine monohydrate, and the mixture is cooled to 10C (internal temperature). To this mixed solution is gradually added 149 g (1.00 mol) of 4,6-dichloropyrimidine (at an internal temperature of 20C or lower), then the ice bath is removed to increase the temperature to room temperature, followed by stirring at the same temperature for 30 minutes. Thereafter, the mixture is further heated to an internal temperature of 60C, and is stirred at the same temperature for 5 hours. After completion of the reaction, 750 ml of water is added thereto, and then the mixture is cooled to an internal temperature of 8C with ice. Crystals precipitated are collected by filtration, spray-washed with water, then spray-washed with isopropanol. The crystals are dried at room temperature for 36 hours to obtain 119 g (white powder; yield: 84.5%) of the intermediate (28). Results of NMR measurement of the thus-obtained intermediate (28) are as follows. 1H-NMR (300 MHz, d-DMSO) 7.80 (s, 1H), 7.52 (s, 2H), 5.98 (s, 1H), 4.13 (s, 4H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1193-21-1, 4,6-Dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; FUJIFILM Corporation; EP2253672; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 4,6-Dichloropyrimidine

Weigh 2 ‘, 3′, 4’-trisubstituted phenylboronic acid 28 (0.016 mol)4,6-dichloropyrimidine 2.458 (0.016 mol), tetrakis (triphenyl-palladium 0.2 g and anhydrous sodium carbonate 3.0 g were placed in a 120 mL sealed tube,With tetrahydrofuran 20 mLwithDeionized water 20mL of the mixed solution as a solvent placed in the tube, add a stir, cover the stopper.The entire device vacuum nitrogen nitrogen replacement 3 ~ 4 times, placed in the oil bath pot,The mixture was heated to 120 C for about 8 h with stirring on a magnetic stirrer.After completion of the reaction, the sealing tube was cooled to room temperature,The solution in the sealed tube was placed in a rotary vial, and the tetrahydrofuran solvent was distilled off under reduced pressure by rotary evaporator.And then extracted with ethyl acetate and water organic products 3 ~ 4 times, vacuum distillation solvent,The spheroidized product was separated by column chromatography using petroleum ether: dichloromethane = 2: 1 to give about 1.13 g of white powder (4-chloro-6-phenylpyrimidine) in 36.3%

With the rapid development of chemical substances, we look forward to future research findings about 1193-21-1.

Reference:
Patent; Anhui University of Technology; Tong Bihai; He Yuheng; Liu Yuanyuan; Jin Long; Zuo Dashuai; Wang Song; (25 pag.)CN106632488; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1193-21-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1193-21-1 as follows.

EXAMPLE 8 This example illustrates the preparation of (E)-methyl 2-[2-(4-fluoropyrimidin-6-yloxy)phenyl]-3-methoxypropenoate, an intermediate for the synthesis of compounds of the invention. A mixture of 4,6-dichloropyrimidine (6.50 g), sulphur tetrafluoride (20.8 g) and Arcton 113 (35 ml) was heated at 50 C. with stirring in a 100 ml Monel reactor for 3.3 hours. The temperature was increased to 100 C. over 25 minutes and maintained at 100 C. for a further 3 hours. The temperature was increased to 151 C. over 20 minutes and maintained at 151 C. for 3 hours. The vessel was then allowed to cool to room temperature. The reaction mixture was poured into saturated sodium hydrogen carbonate solution and extracted with dichloromethane. A sticky solid was observed at the interface and was removed by filtration. The layers were then separated. The organic layer was washed with water, and then distilled at atmospheric pressure to remove the dichloromethane. 4,6-Difluoropyrimidine was isolated by distillation in vacuo (50 C./100 mmHg) as a light yellow oil (400 mg; 7.3% yield); 1 H NMR delta: 6.61 (1H, s); and 8.69 (1H, s)ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-21-1, its application will become more common.

Reference:
Patent; Imperial Chemical Industries PLC; US5145856; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-21-1, name is 4,6-Dichloropyrimidine. A new synthetic method of this compound is introduced below., Safety of 4,6-Dichloropyrimidine

Example 38; Preparation of 4-[6-(4-trifluoromethoxyphenyl)-pyrimidin-4-yl]-benzaldehyde Step 1. 4-Chloro-6-(4-trifluoromethoxy-phenyl)-pyrimidine was prepared by palladium-catalyzed arylation of 4,6-dichloropyrimidine and 4-trifluoromethoxyphenyl boronic acid. 1H NMR (400 MHz, CDCl3) delta 9.05 (s, 1H), 8.14 (d, J=9.8 Hz, 2H), 7.74 (m, 1H), 7.36 (d, J=8.4 Hz, 2H); EIMS 274 m/z (M+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1193-21-1, 4,6-Dichloropyrimidine.

Reference:
Patent; Dow AgroSciences LLC; US2009/209476; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1193-21-1 ,Some common heterocyclic compound, 1193-21-1, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION D 4-Chloro-6-isopropoxy-pyrimidine STR48 A solution of sodium isopropoxide (prepared from 0.77 g sodium) in isopropanol (230 ml) was added dropwise over 8 hours to a stirred solution of 4,6-dichloropyrimidine (5.0 g) in isopropanol (60 ml) at room temperature. The solvent was evaporated in vacuo, the residue taken up in water and extracted three times with diethylether (3*70 ml). The combined ether extracts were dried (Na2 SO4) and evaporated in vacuo to give 4-chloro-6-isopropoxy pyrimidine (4.4 g) as an oil, characterized spectroscopically, and used directly.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-21-1, its application will become more common.

Reference:
Patent; Pfizer Inc.; US4435401; (1984); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 4,6-Dichloropyrimidine

With stirring and at RT, 11.8 ml (12.1 g, 241.6 mmol) of hydrazine hydrate are added dropwise to a solution of 20.0 g (134.3 mmol) of 4,6-dichloropyrimidine in 300 ml of ethanol. If the solution becomes turbid during the addition of the hydrazine hydrate, more solvent (about 400 ml of ethanol) is added. The reaction solution is stirred at RT for a further 12 h. For work-up, the precipitated solid is filtered off, the filter residue is washed twice with in each case 150 ml of water and twice with in each case 100 ml of diethyl ether and the product is dried under reduced pressure. A further crystalline fraction is obtained from the concentrated mother liquor.Yield: 16.8 g (87% of theory)LC-MS (Method 1): Rt=1.17 min; MS (ESIpos): m/z=145 [M+H]+;1H-NMR (400 MHz, DMSO-d6): delta=8.81 (s, 1H), 8.17 (br. s, 1H), 6.75 (s, 1H), 4.48 (br. s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 1193-21-1.

Reference:
Patent; Thede, Kai; Flamme, Ingo; Oehme, Felix; Ergueden, Jens-Kerim; Stoll, Friederike; Schuhmacher, Joachim; Wild, Hanno; Kolkhof, Peter; Beck, Hartmut; Akbaba, Metin; Jeske, Mario; US2012/264704; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1193-21-1, Adding some certain compound to certain chemical reactions, such as: 1193-21-1, name is 4,6-Dichloropyrimidine,molecular formula is C4H2Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1193-21-1.

Synthesis of 4-Chloro-6-(4-trifluoromethyl-phenyl)-pyrimidine A mixture under N2 of 4,6-dichloropyrimidine (447 mg, 3.00 mmol, 1.00 eq.), 4-(trifluoromethyl)phenylboronic acid (188 mg, 0.99 mmol, 0.33 eq.), Na2CO3 (1.59 g, 15.00mmol, 5.00 eq.) and tetrakis(triphenylphosphine)palladium (0) (173 mg, 0.15 mmol, 0.05eq.) in acetonitrile (5 mL) was stirred at 80 C for 24 hours and further at 100 C for 18hours. The reaction mixture was allowed to cool down to r.t. and concentrated in vacuo.The residue was partitioned between DCM and sat. aq. NaHCO3 soln. The layers were separated. The aq. phase was extracted with DCM. The comb. org. phases were washed with sat. aq. NaCI soln., dried over MgSO4, and concentrated in vacuo. The residue was purified by prep. HPLC (column: Waters X-Bridge, 18×50 mm, 10 tm, UV/MS, basicconditions) and concentrated in vacuo to afford the title compound as a white solid. LC-MS 4: tR = 0.94 mm; [M+H] = 259.3

According to the analysis of related databases, 1193-21-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; CIANA, Claire-Lise; KIMMERLIN, Thierry; SIEGRIST, Romain; WO2015/28989; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C4H2Cl2N2

Step 1: 6-chloropyrimidin-4-amine Intermediate 14 4,6-Dichloropyrimidine (7.5 g, 50 mmol) was suspended in ammonium hydroxide (64 mL) in a sealed tube. The tube was sealed and heated at 100 C. in an oil bath overnight. The reaction mixture was cooled to rt. The solid was removed by filtration, washed with water and dried under high vacuum to afford 6-chloropyrimidin-4-amine (5.23 g, 80%) LC-MS (AA) ES+ 130.

With the rapid development of chemical substances, we look forward to future research findings about 1193-21-1.

Reference:
Patent; Millennium Pharmacuticals, Inc.; US2012/15943; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1193-21-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, molecular weight is 148.9781, as common compound, the synthetic route is as follows.

To a solution of 4, 6-dichloro-pyrimidine (10.0 g) in THF (10 mL) were added iPr2NEt (10.4 g) and 50% aqueous MezNH (6.05 g). The mixture was stirred at ambient temperature for 28 hr and poured into saturated aqueous NaHCO3. The aqueous layer was extracted with CHC13 (three times). The combined organic layer was dried over MgS04, filtered, and concentrated under reduced pressure. The residue was suspended in Et20. The precipitate was collected by filtration, washed with Et2O and dried under reduced pressure to give (6-chloro-pyrimidin-4-yl) -dimethyl-amine (6.37 g). ESI MS m/e 157, M ; IH NMR (300 MHz, CDC13) 6 3.12 (s, 6 H), 6.41 (s, 1 H), 8.37 (s, 1 H).

The chemical industry reduces the impact on the environment during synthesis 1193-21-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc; WO2005/95357; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia