Category: 1193-21-1

Reference of 1193-21-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-21-1, name is 4,6-Dichloropyrimidine. A new synthetic method of this compound is introduced below.

45.0 g (302.1 mmol) of 4,6-dichloropyrimidine are initially charged in 450 ml of water. 26.3 g (302.1 mmol) of morpholine are added, and the mixture is stirred at 90 C. for 16 h. The mixture is then cooled to 0 C., and the precipitate formed is filtered off. The precipitate is washed once with 50 ml of water and air-dried.Yield: 51.0 g (85% of theory)LC-MS (Method 4): Rt=1.09 min; MS (ESIpos): m/z=200 [M+H]+;1H-NMR (400 MHz, DMSO-d6): delta=8.35 (s, 1H), 6.95 (s, 1H), 3.62 (s, 8H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1193-21-1, 4,6-Dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Thede, Kai; Flamme, Ingo; Oehme, Felix; Ergueden, Jens-Kerim; Stoll, Friederike; Schuhmacher, Joachim; Wild, Hanno; Kolkhof, Peter; Beck, Hartmut; Akbaba, Metin; Jeske, Mario; US2012/264704; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-21-1, name is 4,6-Dichloropyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4,6-Dichloropyrimidine

The 4,6-dichloropyrimidine 3.88g (26mmol) were dissolved in 40ml of isopropyl alcohol and p-anisidine 2.46g (20mmol), under stirring, 1.5ml of concentrated sulfuric acid was added dropwise, the reaction was heated at reflux for 6 hour monitoring of the reaction system. After completion of the reaction was cooled to room temperature, placed in 4 refrigerator overnight, the precipitated white solid was filtered off with suction, the filter cake was dried in an oven, to give 6-chloro -N- (4- methoxyphenyl) pyrimidin-4-amine The crude product 4.3g, 93% yield.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1193-21-1, 4,6-Dichloropyrimidine.

Reference:
Patent; XI’AN JIAOTONG UNIVERSITY; ZHANG, JIE; ZHANG, TAO; DONG, JINYUN; PAN, XIAOYAN; HE, LANGCHONG; LU, WEN; WANG, SICEN; SHI, YALING; (19 pag.)CN104262263; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1193-21-1, name is 4,6-Dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4,6-Dichloropyrimidine

To 398 4,6-dichloropyrimidine (131 g, 879 mmol), 399 4-(trifluoromethoxy)phenylboronic acid (200g, 970 mol), 106 potassium carbonate (244 g, 1.77 mol) and 266 tetrakis(triphenylphosphine)palladium(0) (21.5 g, 18.6 mmol) were added 115 1,4-dioxane (3.0 L) and 52 water (200 mL) and the mixturewas stirred at 105 C. for 6 hr. The insoluble material was filtered off, the filtrate was concentrated underreduced pressure and the obtained residue was purified by silica gel column chromatography (petroleumether/ethyl acetate) to give the 400 title compound ( 78.0 g , 284 mmol, 32%). MS (ESI) m/z 275 (M+H)+ 1H NMR (400 MHz, CDCl3) delta 9.04 (s, 1H), 8.13 (d, J=8.6 Hz, 2H), 7.73 (s, 1H), 7.36 (d, J=8.6 Hz, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 1193-21-1.

Reference:
Patent; EA PHARMA CO., LTD.; KOBAYASHI, Kaori; SUZUKI, Tamotsu; KAWAHIRA, Mizuki; FUJII, Tomohiro; SUGIKI, Masayuki; OHSUMI, Koji; OKUZUMI, Tatsuya; (285 pag.)US2016/332999; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1193-21-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a suspension of 4,6-dichloropyrimidine 53 (3.0 g, 20 mmol) in isopropanol (40 mL) was added appropriate amine at such a rate that the internal temperature did not rise above 40 C. After completion of the addition, the reaction mixture was stirred for 1 h at 25 C. Water (30 mL) was added, and the resulting suspensio nwas cooled in an ice bath to 0 C. The precipitated product was filtered off and washed with cold isopropanol/water (2:1, 50 mL) and water. The collected material was dried in vacuo to afford the title compounds.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1193-21-1, 4,6-Dichloropyrimidine.

Reference:
Article; Zhan, Wenhu; Li, Daqiang; Che, Jinxin; Zhang, Liangren; Yang, Bo; Hu, Yongzhou; Liu, Tao; Dong, Xiaowu; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 11 – 20;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1193-21-1, Adding some certain compound to certain chemical reactions, such as: 1193-21-1, name is 4,6-Dichloropyrimidine,molecular formula is C4H2Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1193-21-1.

First, 5.0 g of 4,6-dichloropyrimidine,4.9 g of phenylboronic acid, 7.1 g of sodium carbonate, 0.34 g of bis (triphenylphosphine) palladium (II) dichloride (abbreviation: PdCl 2 (PPh) 2) 20 mL of acetonitrile,20 mL of water was placed in a 100 mL round bottom flask provided with a reflux tube, The inside of the flask was replaced with argon. Thereafter, microwave (2.45 GHz, 100 W) was irradiated for 1 hour and heated. The organic layer was extracted from the resulting mixture by dichloromethane,The organic layer was washed with water,Washed with saturated brine,Magnesium sulfate was added and dried. The mixture was naturally filtered. The solvent of the filtrate was removed by distillation,The residue thus obtained was subjected to solid-By purification by flash column chromatography using dichloromethane as a developing solvent,1.6 g of the desired product (yield: 23%, pale yellow solid) was obtained.

According to the analysis of related databases, 1193-21-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Handotai Energy Kenkyusho Corporation; Inoue, Hideko; Kanamoto, Mickey; Seo, Hiromi; Takahashi, Tsuyoshi; Seo, Satoshi; (43 pag.)KR2015/2504; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1193-21-1, name is 4,6-Dichloropyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 1193-21-1

298 mL of methanol was added to 387 mL (7.98 mols) of hydrazine monohydrate, cooled at 10C (inside temperature), and 149 g (1.00 mol) of 4,6-dichloropyrimidine was gradually added to the mixture liquid (at inside temperature of not higher than 20C), then the ice bath was removed, and this was restored to room temperature and stirred at the temperature for 30 minutes. Afterwards, this was further heated up to 60C (inside temperature), and stirred at the temperature for 5 hours. After the reaction, 750 mL of water was added thereto, and cooled with ice to 8C (inside temperature), and the precipitated crystal was collected through filtration, washed with water poured thereto, and then with isopropanol poured thereto. This was dried at room temperature for 36 hours to give 119 g of the intermediate (c) (white powder, yield 84.5%). The NMR data of the obtained intermediate (c) are as follows: 1H-NMR (300 MHz, d-DMSO): 7.80 (s, 1H), 7.52 (s, 2H), 5.98 (s, 1H), 4.13 (s, 4H)

The synthetic route of 1193-21-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJIFILM Corporation; EP2228409; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1193-21-1, 4,6-Dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

4,6-dichloro-2-phenylpyrimidineN-Butyl lithium (3.22 g, 50.3 mmol, and 1.6N in hexane) was added dropwise to a stirred solution of bromobenzene (7.9 g, 50.3 mmol) in THF (70 mL) over a period of 30 min at -78 ¡ãC, and reaction was continued stirring for 2 h. The generated phenyl lithium was added dropwise to a stirred solution of 4, 6-dichloropyrimidine (5 g, 33.5 mmol) in THF (50 mL) over a period of 45 min at -78 0C, and reaction was continued stirring for 30 min. Then, the reaction mixture was slowly heated to 0 ¡ãC and quenched with water (100 ml), DDQ (7 g, 30. 8 mmol) dissolved in THF (70 mL) was added portionwise and stirred for 10 min. Then, the reaction mixture was washed with 10percent NaOH (50 mL), extracted with CH2Cl2 (3×100 mL), washed with brine (100 mL), dried (Na2SO4) and concentrated. The concentrated product was purified through silica column chromatography using pet. ether to afford 4,6-dichloro-2- phenylpyrmimidine (example 21, 2.6 g, 35 percent) as a white solid. Rf: 0.3 (100percent PE). 1H NMR (400 MHz, CD3OD): delta 8.41-8.39 (m, 2H), 7.60 (s, IH), 7.58-7.50 (m, 3H). m/e (M+l): 224.8.

The synthetic route of 1193-21-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MIIKANA THERAPEUTICS, INC.; WO2008/154026; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1193-21-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1193-21-1, name is 4,6-Dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

4,6-Dichloropyrimidine (20.85 g, 139 mmol) and 7 N Ammonia in methanol (200 mL) were heated to 85 C in a sealed glass bomb for 16 h. The reaction was cooled to ambient temperature, the solvent evaporated, and the residue recrystalized from water yielding compound 17 (12.07 g, 93.17 mmol, 67% yield). 1H NMR (400 MHz, DMSO-D6): S 6.43 (s, 1 H), 7.22 (s, 2 H), 8.18 (s, 1 H). ESI-MS mXz : 130 (M + H) +.

According to the analysis of related databases, 1193-21-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SUNESIS PHARMACEUTICALS, INC.; MORROW, Joelle; WO2005/34840; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1193-21-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Sodium thiomethoxide (28.2 g, 0.403 mol) was suspended in 350 mL of THF and stirred at ambient temperature under a blanket of nitrogen gas while 4,6- dichloropyrimidine (50 g, 0.33 mol) was added. After the addition was completed, the reaction was stirred and heated at 60 0C for 4 hours. The solvent was removed under reduced pressure and the residue was dissolved into 500 mL of 0.25N sodium hydroxide and extracted 3 times with ethyl acetate. The organics were combined and backwashed with water, brine, and 1: 1 brine/lN HCl. The combined organic layer was dried (Na2SO4 anh.) and the solvent was removed under reduced pressure. The crude material was re- crystallized from hot petroleum ether to afford ~24 g of material. LC/MS (M+l): 161.

According to the analysis of related databases, 1193-21-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2009/85913; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia