Category: 1194-21-4

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1194-21-4, name is 2-Amino-6-chloropyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1194-21-4

PREPARATION 7 2-Amino-5-iodo-6-chloro-4-pyrimidinol To 1.45 grams (10.0 millimoles) of 6-chloro-isocytosine is added 15 ml. of dimethylformamide (DMF) and 2.27 grams (10.08 millimoles) of N-iodosuccinimide. With protection from external moisture, the mixture is heated on a steam bath for one-hour hour. The resulting brownish red solution is allowed to stand overnight at room temperature with continued exclusion of moisture. The solution is evaporated under reduced pressure and the residual solid azeotroped once with ethanol in vacuo. The resulting solid is triturated with glacial acetic acid. The insoluble solid is collected, washed with a small volume of glacial acetic acid, then with acetone. The solid is re-triturated with glacial acetic acid, collected, washed with acetone and air-dried. Yield, 1.50 g. Evaporation of the combined filtrate in vacuo, trituration of the residue with water, then acetone gives, after collecting and drying, 970 mg. of second-crop material. The first-crop material is crystallized twice from glacial acetic acid to give 540 mg. of 2-amino-5-iodo-6-chloro-4-pyrimidinol which decomposes at >270, has lambdamax0.1N NaOh 236 nm. (epsilon9,150); 285 nm. (epsilon6,200) and the infrared absorption below. NH/CH, 3380, 3300, 3190, 3130; O=O/C=C/C=N/NH deformation, 1670v.s., 1580, 1540; C–N/Other, 1320, 1215, 1010; Other, 910, 755 cm-1. Analysis Calcd. for: C4 H3 CllN3 O: C, 17.73; H, 1.11; Cl, 13.08; l, 46.83; N, 15.51. Found: C, 18.51; H, 2.24; Cl, 13.38; l, 46.50; N, 14.70.

With the rapid development of chemical substances, we look forward to future research findings about 1194-21-4.

Reference:
Patent; The Upjohn Company; US3932617; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1194-21-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1194-21-4, name is 2-Amino-6-chloropyrimidin-4(3H)-one, molecular formula is C4H4ClN3O, molecular weight is 145.55, as common compound, the synthetic route is as follows.

6-Amino-4-chloropyrimidin-2(1H)-one (3, 200 mg, 0.84 mmol) and 2-methyl-5-nitroaniline (627 mg, 2.52 mmol) were heated at 170 C for 3 h. The mixture was then cooled to rt and diethyl ether was added. The mixture was sonicated for 5 min. The suspension was filtered, and the filter cake was dissolved in MeOH and purified by column chromatography (silica gel, dichloromethane/methanol 9:1 v/v) to afford 4 (128 mg, 60%) as a brown solid.

Statistics shows that 1194-21-4 is playing an increasingly important role. we look forward to future research findings about 2-Amino-6-chloropyrimidin-4(3H)-one.

Reference:
Article; Kim, Hee Jin; Oh, Chang-Hyun; Yoo, Kyung Ho; Bulletin of the Korean Chemical Society; vol. 34; 8; (2013); p. 2311 – 2316;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia