Related Products of 1194-78-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1194-78-1 as follows.
(D) 7-Chloro-1H-1,2,3-triazolo[4,5-d]pyrimidin-5-amine A solution of 6-chloro-2,4,5-pyrimidinetriamine (10.94 g, 0.0686 mol) and isoamyl nitrite (9.20 ml, 0.0686 mol)in dioxane (500 ml, freshly purified by passage through basic alumina) was heated under nitrogen with stirring for 2 hours at 90. The reaction mixture was cooled, treated with activated carbon, filtered, and concentrated to 150 ml. Petroleum ether (250 ml, bp 35-60) was added. The precipitate was filtered, washed the petroleum ether (50 ml) and dried in vacuo over P2 O5 at 40 for 16 hours to give 9.23 g of crude desired product which was then used in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1194-78-1, its application will become more common.
Reference:
Patent; E. R. Squibb & Sons, Inc.; US5126345; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia