Category: 1195-08-0

Adding a certain compound to certain chemical reactions, such as: 1195-08-0, 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, blongs to pyrimidines compound. Safety of 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

General procedure: To a solution of the pseudothiohydantoin 6a (139 mg, 1.2 mmol), and sodium acetate (328 mg, 4.0 mmol) in acetic acid (5 ml) was added 5-phenyl-2-furaldehyde 5a (172 mg,1.0 mmol) at 25C. The solution was refluxed at 135C for 12 h. The precipitate was filtered and washed with water and diethyl ether. The filter cake was dried under high vacuum to afford 230 mg (85%) of compound 7a as an orange solid.

The synthetic route of 1195-08-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5842 – 5848;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1195-08-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1195-08-0, name is 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.

To a DMF (0.35 M) solution of 5-formyluracil (1 eq.) was added sequentially at O0C 1 – 5 bromo-3-methoxypropane (2.2 eq.) and DBU (2.2 eq.). The resulting solution was stirred at RT for 72 h. The volatiles were then removed in vacuo. The crude product mixture thus obtained was directly subjected to purification by way of column chromatography (SiCb, EtOAc) to afford the title compound as a yellow oil.

The chemical industry reduces the impact on the environment during synthesis 1195-08-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2009/140769; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1195-08-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1195-08-0, name is 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.

General procedure: To a stirred solution of free amine ester (1 equiv was previously isolated: 1 equiv of the corresponding hydrochloride with 1.3 equiv K2CO3, in a mixture of AcOEt/H2O during 1h. It was washed with water and the organic fase evaporated), in toluene (2 mL) was added 5-formyluracile (1 equiv, 0.5 mmol). After that, dipolarophile (1.0 equiv, 0.5 mmol) and AgOAc (5 mol%). The solvent was removed under reduced pressure. The crude mixture was filtrated through Celite with warm EtOH to furnish the corresponding product.

Statistics shows that 1195-08-0 is playing an increasingly important role. we look forward to future research findings about 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde.

Reference:
Article; Selva, Elisabet; Castello, Luis M.; Mancebo-Aracil, Juan; Selva, Veronica; Najera, Carmen; Foubelo, Francisco; Sansano, Jose M.; Tetrahedron; vol. 73; 49; (2017); p. 6840 – 6846;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1195-08-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1195-08-0, name is 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.

Example 8 5-{4-[2-(4-tert-Butyl-phenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-piperazin-1-ylmethyl}-1H-pyrimidine-2,4-dione (9). 2-(4-tert-Butyl-phenyl)-7-piperazin-1-yl-3H-imidazo[4,5-b]pyridine (7) (50 mg, 0.15 mmol) and 5-formyluracil (21 mg, 0.15 mmol) were dissolved in NMP (4 ml) and sodium triacetoxyborohydride (64 mg, 0.30 mmol) was added. The reaction mixture was allowed to stir for 18 h under nitrogen. It was judged complete by MS, and purified by HPLC Method E to yield the title product 9 (25 mg (36%), 0.054 mmol). 1H NMR (DMSO-d6): delta 11.45 (s, 1H), 11.30 (d, J=3 Hz, 1H), 9.85(bs, 1H), 8.11 (d, J=8.3 Hz, 3H), 7.74 (d, J=6.1 Hz, 1H), 7.54 (d, J=8.3 Hz, 2H), 6.78 (s, 1H), 4.05 (s, 2H), 3.20-3.65 (m, 8H), 1.33 (s, 9H). (ESI-POS): [M+H]+=460; MS(ESI-NEG):[M-H]-=458.

Statistics shows that 1195-08-0 is playing an increasingly important role. we look forward to future research findings about 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde.

Reference:
Patent; WYETH; US2006/189617; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1195-08-0, name is 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, molecular formula is C5H4N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1195-08-0

General Synthesis of Tethered Oxime Dimers. A set of 14 aryl aldehydes was selected for library synthesis for coupling to the three uracil containing aldehydes using the O, O’-diaminoalkanediol linkers as follows. To each 0.5-ml well of a Matrix microtiter plate was added a DMSO stock solution of AcOH (20 mul, 150 niM, 3 mumol), uracil aldehyde 1, 2 or 3 (20 mul, 150 mM, 3 mumol) and a single aryl aldehyde (20 mul, 150 niM, 3 mumol). The plate was carefully agitated to make the solutions homogenous. To each of the uracil-aryl aldehyde mixture was added a DMSO solution of the O, O’-diaminoalkanediol linkers containing each of the five linker lengths in equal proportion (22 mul, 150 mM, 3.3 mumol total amine equivalents). The plate was sealed, further agitated and incubated in an oven for 12 h at 370C.The most potent inhibitors from this first screen 2-(2)-3 and 3-(3)-13) were synthesized in larger scale and thoroughly characterized after HPLC purification of the heterodimers:2-(2)-3: 1H NMR (400 MHz, DMSO-d6): delta 8.05 (s, 1 H), 7.91 (s, 1 H), 7.78 (s, 1 H), 7.04 (s, J= 2.4 Hz, 1 H), 6.86 (m, 1 H), 6.74 (d, J= 8.0 Hz, 1 H), 4.26 (s, 1 H); 13C NMR (100 MHz, DMSO-d6): delta 162.40, 151.04, 149.25, 147.92, 145.75, 142.74, 140.66, 123.05, 119.88, 115.74, 113.10, 104.31, 71.82, 71.54. UV/Vis: Aax 275 nm; HRMS (m/z): [M+Naf calcd for C14H14N4O6Na, 357.08; found, 357.08.3-(3)Lambda3: 1H NMR (400 MHz, DMSO-d6): delta 9.10 (bs, H), 8.01 (s, 1 H), 7.94 (s, 1 H), 7.04 (d, J= 1.6 Hz, 1 H), 6.82 (d, J= 7.6 Hz, 1 H), 6.74 (d, J= 7.6 Hz, 1 H), 5.78 (s, 1 H), 4.26 (t, J= 6.8 Hz, 2 H), 4.12 (t, J= 6.0 Hz, 2 H), 2.06 (t, J= 6.8 Hz, 2 H); 13C NMR (125 MHz, DMSO-d6): delta 163.95, 151.15, 148.96, 148.04, 145.89, 144.73, 142.23, 123.12, 119.83,-66-211592 1 EPO 115.81, 113.15, 101.60, 71.94, 69.76, 28.46; UV/Vis: lambdamax 273 nm; HRMS (m/z): [M+H]+ calcd for Ci5Hi7N4O6, 349.11; found, 349.11.

With the rapid development of chemical substances, we look forward to future research findings about 1195-08-0.

Reference:
Patent; THE JOHNS HOPKINS UNIVERSITY; WO2006/135763; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1195-08-0 ,Some common heterocyclic compound, 1195-08-0, molecular formula is C5H4N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Amine 2.2; 5-[(cyclopropylamino)methyl]-l ,3-bis(3-methoxypropyl)pyrimidine-2,4(lH,3/i)- dione; Step 1 : l,3-bis(3-methoxypropyl)-2,4-dioxo-l,2,3,4-tetrahvdropyrimidine-5-carbaldehvde; To a solution of 2,4-dioxo-l,2,3,4-tetrahydropyrimidine-5-carbaldehyde (1 eq.) and l-bromo-3-methoxypropane (2.2 eq.) at rt in DMF (0.36 M) was added DBU (2.2 eq.). The reaction mixture was stirred at rt 3 days, concentrated in vacuo, and the residue purified by flash chromatography (SiO2; EtOAc) to afford the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1195-08-0, 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2009/70869; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1195-08-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1195-08-0, name is 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.

To a slurry of 400mg of 5-formyluracil (2.8 mM) in DMF (10 mL) at room temperature was added sodium hydride (280 mg, 7 mM, 60% in oil). After stirring for 30 min., MeI (1.013 g, 7.2 mM) was added. When the turbid reaction mixture became a homogeneous yellow solution tlc revealed the absence of starting uracil. The reaction mixture was treated with MeOH and water, concentrated on the rotovap and the residue partitioned between MeOH and hexane. The MeOH fraction was concentrated and the residue partitioned between chloroform and water. The organic phase dried (MgSO4), filtered and concentrated to give 420 mg (89% yield) of 1,3-dimethyl-5-formyluracil as an off-white waxy solid. 1H-NMR (DMSO-d6), delta=9.82 (s, 1H), 8.52 (s, 1H), 3.43 (s, 3H), 3.2 (s, 3H). LC/MS; rt=0.34 mins. m/z=169, [M+H]+.

Statistics shows that 1195-08-0 is playing an increasingly important role. we look forward to future research findings about 2,4-Dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde.

Reference:
Patent; Wyeth; US2006/19965; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia