Category: 1197953-49-3

Reference of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

General procedure: To a solution of 2,5-dichloro-N-(2-(dimethylphosphoryl)phenyl)pyrimidin-4-amine (2g, 6.3mmol) in DMF (30mL) were added s-2a (2.4g, 7.8mmol)Pd(OAc)2 (176mg, 0.78mmol)Xantphos (810mg, 1.4mmol) and Cs2CO3(6.4g, 19.6mmol) in microwave tube, the solution was purged and refilled with nitrogen three times. Then the mixture was stirred at 110C for 2h in the microwave. After the starting material was consumed, the reaction mixture was filtered through a pad of silica gel and most of the solvent of the filtrate was removed under the reduced pressure. Then the mixture was quenched with water, extracted with ethyl acetate, washed with water and brine, dried over anhydrous Na2SO4. The solvent was evaporated under the reduced pressure and the residue was purified by reverse phase ISCO (C18) to give the title compound s-3a as a brown solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sun, Ning; Ren, Chaowei; Kong, Ying; Zhong, Hui; Chen, Jinju; Li, Yan; Zhang, Jianshui; Zhou, Yuedong; Qiu, Xing; Lin, Haifan; Song, Xiaoling; Yang, Xiaobao; Jiang, Biao; European Journal of Medicinal Chemistry; vol. 193; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C12H12Cl2N3OP, blongs to pyrimidines compound. Formula: C12H12Cl2N3OP

A suspension of 2(1.27g, 4.0 mmol), 3-Boc-amino-5-methoxyaniline(965mg, 4.0mmol), palladium acetate(133mg, 0.59mmol), XantPhos(352mg, 0.61 mmol) and potassium phosphate(1.4g, 6.6mmol) in anhydrous DMF(35 mL) was heated at 120 C overnight. After the reaction was cooling to room temperature, ethyl acetate was added to dilute the reaction and the content was filtered through celite. Solvent was removed under vacuum. The residue was purified by flash column chromatography on silica gel to give pure product 1.3g (yield 62%) as a tan solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, and friends who are interested can also refer to it.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; ZHU, Xiaotian; WANG, Yihan; SHAKESPEARE, William, C.; HUANG, Wei-Sheng; DALGARNO, David, C.; WO2013/169401; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1197953-49-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. This compound has unique chemical properties. The synthetic route is as follows.

Add compound 13 to a 25 mL single-mouth bottle with magnetic stirrer and condenser(160 mg, 0.61 mmol), compound 7 (192 mg, 0.61 mmol)And ethylene glycol monomethyl ether (4mL), stir and dissolve,Add hydrogen chloride isopropanol solution (0.91 mmol, 0.18 mL, 5 M) dropwise.The temperature was raised to 120 C under a nitrogen atmosphere and stirred to react overnight. Cool to room temperature,Add water(10 mL) and saturated sodium bicarbonate (5 mL), dichloromethane (15 mL×3)The organic phase was combined, washed with saturated brine, dried over anhydrous sodiumConcentrated, the residue was passed through a silica gel column to give a white solid200 mg, the yield was 60.7%.

According to the analysis of related databases, 1197953-49-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (49 pag.)CN109851638; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1197953-49-3 ,Some common heterocyclic compound, 1197953-49-3, molecular formula is C12H12Cl2N3OP, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

AP26113 intermediate (2g, 6.3mmol) was added sequentially in a standard microwave reaction tube at room temperature.SIAIS 1197129 (2.4 g, 7.8 mmol), Pd(OAc) 2 (176 mg, 0.78 mmol), Xantphos (810 mg, 1.4 mmol),cesium carbonate (6.4 g, 19.6 mmol), 30 mL DMF, followed by argon exchange, microwave reaction at 110 C for 1.5 h. TLC detection reactionAfter the bundle, the mixture was filtered through silica gel, water-purified, ethyl acetate, washed with water, dried over anhydrous sodium sulfate,Methanol and water gave a reddish brown solid (900 mg) directly to the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1197953-49-3, its application will become more common.

Reference:
Patent; ShanghaiTech University; Yang Xiaobao; Jiang Biao; Song Xiaoling; Lin Haifan; Sun Ning; Chen Jinju; Qiu Xing; Ren Chaowei; Kong Ying; (232 pag.)CN109912655; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1197953-49-3 ,Some common heterocyclic compound, 1197953-49-3, molecular formula is C12H12Cl2N3OP, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

AP26113 intermediate (2g, 6.3mmol) was added sequentially in a standard microwave reaction tube at room temperature.SIAIS 1197129 (2.4 g, 7.8 mmol), Pd(OAc) 2 (176 mg, 0.78 mmol), Xantphos (810 mg, 1.4 mmol),cesium carbonate (6.4 g, 19.6 mmol), 30 mL DMF, followed by argon exchange, microwave reaction at 110 C for 1.5 h. TLC detection reactionAfter the bundle, the mixture was filtered through silica gel, water-purified, ethyl acetate, washed with water, dried over anhydrous sodium sulfate,Methanol and water gave a reddish brown solid (900 mg) directly to the next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1197953-49-3, its application will become more common.

Reference:
Patent; ShanghaiTech University; Yang Xiaobao; Jiang Biao; Song Xiaoling; Lin Haifan; Sun Ning; Chen Jinju; Qiu Xing; Ren Chaowei; Kong Ying; (232 pag.)CN109912655; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1197953-49-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. This compound has unique chemical properties. The synthetic route is as follows.

2-[D3]methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline (1.25 g, 4.06 mmol), (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide (the compound of Formula IV) (0.92 g, 2.90 mmol), 14% hydrogenchloride-ethanol (7.5 g, 29 mmol) and ethylene glycol monomethyl ether (22mL) were respectively added in a 35 mLpressure tubing, heated in a microwave to 120C and reacted for 5.5 hours. After the reaction was completed, thereaction solution was cooled down to room temperature and evaporated under reduced pressure to remove the solvent.The residue was dissolved in dichloromethane (60mL) and adjusted to alkaline pH by adding saturated sodium carbonatesolution. The resulting solution was separated. The organic phase was washed with saturated brine (30 mL), dried overanhydrous sodium sulfate, and evaporated under reduced pressure to remove the solvent. The residue obtained wassubjected to silica gel column chromatography (mobile phase, dichloromethane : methanol : triethylamine = 300 : 30 :1.5) to give a crude product. The crude product was beaten with ethyl acetate (10 mL) to give (2-((5-chloro-2-((2-[D3]methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethyl phosphorusoxide (0.18 g, 11.0% yield), with >98% of D3 content.1H-NMR(300 MHz, CDCl3): delta = 10.80 (s, 1H), 8.62 (dd, J = 4.4, 8.2 Hz, 1H), 8.09-8.08 (m, 2H), 7.47 (dd, J = 7.7, 8.0Hz, 1H), 7.31-7.25 (m, 1H), 7.11 (dd, J = 7.4, 7.0 Hz, 1H), 6.54 (s, 1H), 6.48 (dd, J = 1.4, 8.4 Hz, 1H), 3.65 (d, J = 12.2Hz, 2H), 2.73-2.41 (m, 11H), 2.37 (s, 3H), 1.95 (d, J = 11.2 Hz, 2H), 1.85, 1.80 (2s, 6H), 1.73-1.66 (m, 2H).13C-NMR (75 MHz, CDCl3) : delta = 157.76, 155.87, 154.93, 149.29, 147.48, 143.90, 143.87, 132.33, 132.30, 129.52,129.37, 123.10, 123.01, 122.44, 122.27, 122.09, 120.58, 119.55, 108.36, 105.99, 101.01, 61.78, 55.27, 50.46, 48.78,45.83, 28.19, 19.02, 18.08.HRMS (ESI, [M+H]+) m/z: 587.2861.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.

Reference:
Patent; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; ZHANG, Yinsheng; LIU, Baomin; YANG, Beibei; (35 pag.)EP3381925; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1197953-49-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. A new synthetic method of this compound is introduced below.

Compound a6 (150 mg, 0.5 mmol) was dissolved in acetone/water (3:1 by volume,A total of 8 mL), adding compound b3-1 (200 mg, 0.6 mmol), 3 drops of concentrated hydrochloric acid, sealed, heated to 100 C, stirred overnight.Cool to room temperature and adjust to pH 12 with 10% aqueous sodium hydroxide.Extract three times with dichloromethane, dry the organic phase, filter and concentrate.Column chromatography was carried out with ethyl acetate, dichloromethane/methanol (10:1 by volume) as mobile phase.Yield 110 mg of a pale yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1197953-49-3, its application will become more common.

Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1197953-49-3, blongs to pyrimidines compound. Product Details of 1197953-49-3

General procedure: To asolution of (2-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide (3f) (0.1 g, 0.334 mmol) and 4-fluoro-2-methoxy-5-nitroaniline (0.124 g, 0.667 mmol) in sec-butanol(2 mL) was added potassium carbonate (0.231 g, 1.669 mmol). Thereaction mixturewas stirred at 80 C for 10 min and then Pd2 (dba)3(0.031 g, 0.033 mmol) and Xphos (0.016 g, 0.033 mmol) were addedrapidly. The reaction mixture was stirred at 100 C for 2 h. Aftercompletion of the reaction, the resulting mixture was hot-filteredthrough Celite and washed with DCM. The filtrate was concentratedunder reduced pressure and then purified by flash columnchromatography on silica gel (0-20% MeOH in DCM) to afford 4f asa yellowish solid (0.128 g, 85%).

The synthetic route of 1197953-49-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jang, Jaebong; Son, Jung Beom; To, Ciric; Bahcall, Magda; Kim, So Young; Kang, Seock Yong; Mushajiang, Mierzhati; Lee, Younho; Jaenne, Pasi A.; Choi, Hwan Geun; Gray, Nathanael S.; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 497 – 510;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1197953-49-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. This compound has unique chemical properties. The synthetic route is as follows.

171 mg of compound c25-12 and 165 mg of compound b3-1 were dissolved in 13 mL of ethylene glycol monomethyl ether and 0.43 mL of ethanol, and 0.26 mL of a hydrogen chloride solution (5.6 M) was added thereto, and the mixture was reacted at 120 C for 18 hours.The solvent was removed under reduced pressure, water was added to PH 9 with potassium carbonate, extracted with dichloromethane, dried, concentrated, obtained by column chromatography 24mg compound c-25;

According to the analysis of related databases, 1197953-49-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

The above compound B (0.1g, 0.53mmol) and 4-(ortho dimethyl phosphinyl anilino)- 5- chloro – 2-chloro pyrimidine (0.17g, 0.53mmol) were dissolved in a mixture of 2-butanol (1.2mL) & trifluoroacetic acid (0.25 mL) and were heated to 100 C in a seal tube for overnight. The reaction mixture was then cooled to rt and poured into a saturated NaHCC solution while stirring to afford an orange solid which was filtered, washed with Et.20 to remove final traces of water. The product was dried to afford C (0.19g) which was directly used in the next step.

According to the analysis of related databases, 1197953-49-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; ZHU, Xiaotian; WANG, Yihan; SHAKESPEARE, William, C.; HUANG, Wei-Sheng; DALGARNO, David, C.; WO2013/169401; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia