Category: 1197953-49-3

Related Products of 1197953-49-3 ,Some common heterocyclic compound, 1197953-49-3, molecular formula is C12H12Cl2N3OP, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of 5 (0798) A solution of 2 (1.0 eq), 4 (1.4 eq), and 2.5 M HCl in ethanol (excess) in 2-methoxyethanol was sealed and heated at 120 C. with stirring for 5.5 hours and then cooled to r.t. The reaction was repeated 5 times and combined. The mixture was filtered and evaporated. Saturated Na2CO3 was added, followed by DCM with stirring strongly. The layers were separated and the aqueous layer was extracted with DCM. The organics were dried, evaporated and chromatographed [EtOAc/MeOH (7M ammonia) 20:1] to give a yellow solid. EtOAc was added and the suspension was refluxed for 30 minutes. After cooled to r.t., filtration gave a solid, which was dissolved in DCM, filtered, and evaporated to afford 5 as an off-white solid (66% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARIAD PHARMACEUTICALS, INC.; Wang, Yihan; Huang, Wei-Sheng; Liu, Shuangying; Shakespeare, William C.; Thomas, Ranny M.; Qi, Jiwei; Li, Feng; Zhu, Xiaotian; Kohlmann, Anna; Dalgarno, David C.; Romero, Jan Antoinette C.; Zou, Dong; US2015/225436; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. A new synthetic method of this compound is introduced below., Computed Properties of C12H12Cl2N3OP

Add compound 8a to a 25 mL single-mouth bottle with magnetic stirrer and condenser(760 mg, 3.21 mmol), compound 5a (1.01 g, 3.21 mmol)And ethylene glycol monomethyl ether (10mL), stir and dissolve, add hydrogen chloride isopropanol solution(4.82mmol, 0.96mL, 5M),The temperature was raised to 120 C under a nitrogen atmosphere and stirred to react overnight. Cool to room temperature,Add water (10 mL) and saturated sodium bicarbonate (5 mL) and dichloromethane (15 mL×3)The organic phase was combined, washed with saturated brine and dried over anhydrous sodium sulfate.Filtration, concentration, and residue over silica gel to give a white solid600 mg, the yield was 36.1%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (49 pag.)CN109851638; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

To a solution of tert-butyl-9- (4-amino-3-methoxyphenyl) -3,9-diazaspiro [5.5] undecane-3-carboxylate(80 mg, 0.213 mmol) Tert-butanol (3.0 mL) was added a solution of (2 – ((2,5-dichloropyrimidin-4-yl) amino) phenyl)dimethylphosphine oxide (67 mg, 0.213 mmol) and methanesulfonic acid (119 mg, 1.07 mmol).The reaction solution wasthen heated to 90 C undernitrogenfor 16 hours.The reaction mixture was concentrated and subjected to preparative separation to give the title compound as a yellow solid(25 mg, yield 21%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Qilu Pharmaceutical Co., Ltd.; Ding Zhaozhong; Chen Shuhui; Liu Xile; Wan Haiwen; Zhang Lu; (27 pag.)CN106928275; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, molecular formula is C12H12Cl2N3OP, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1197953-49-3

Compound c24-10 (200 mg, 0.58 mmol) was dissolved in 18 ml of ethylene glycol monobutyl ether, then compound b3-1 (237 mg, 0.75 mmol) was added with stirring at room temperature.0.36 ml of a hydrochloric acid solution in ethanol(5.6 M) was reacted at 120 C overnight.TLC showed that the reaction was completed, diluted with water and ethyl acetate.Concentrated to give crude product by column chromatography to give c-24,20mg.

With the rapid development of chemical substances, we look forward to future research findings about 1197953-49-3.

Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

Add compound 20 (150 mg, 0.6 mmol), compound 5 (189 mg, 0.6 mmol) and ethylene glycol monomethyl ether (3 mL) to a 25 mL single-necked flask equipped with a magnetic stirring and a condensing tube, stir and dissolve, and add hydrogen chloride dropwise. Isopropyl alcohol solution(0.9 mmol, 0.18 mL, 5 M), the temperature was raised to 120 C under a nitrogen atmosphere and the reaction was stirred overnight. Cool to room temperature and add water(10 mL) and saturated sodium bicarbonate (5 mL), dichloromethane (15 mL¡Á3)The combined organic layers were washed with brine, dried over anhydrous sodium sulfateThe residue was passed through a silica gel column to give a white solid160mg,The yield was 50.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (67 pag.)CN109369721; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. This compound has unique chemical properties. The synthetic route is as follows. Safety of (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide

Compound 33 (224 mg, 0.6 mmol), compound 5 (189 mg, 0.6 mmol) and ethylene glycol monomethyl ether (3 mL) were added to a 25 mL single-necked flask equipped with a magnetic stirring and a condensing tube, and the mixture was stirred and dissolved.A hydrogen chloride isopropanol solution (0.9 mmol, 0.18 mL, 5 M) was added dropwise, and the mixture was heated to 120 C under a nitrogen atmosphere and stirred overnight. Cool to room temperature and add water(10 mL) and saturated sodium bicarbonate (5 mL), dichloromethane (15 mL¡Á3),Dry over sodium sulfate, filter, concentrate, residue over silica gel220mg, the yield is 56.2%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (67 pag.)CN109369721; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia