Category: 120747-84-4

Reference of 120747-84-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde, molecular formula is C5H5N3O, molecular weight is 123.11, as common compound, the synthetic route is as follows.

To a mixture of 166 mg (1.35 mmol) of aminopyrimidine 67, 17 mg (0.14 mmol) of DMAP and 418 muL (3.00 mmol) OfEt3N in 10 mL of THF was added 589 mg (2.7 mmol) of (BOC)2O. The mixture was stirred at room temperature for 5 h, concentrated-dry loaded on silica gel and flash chromatographed (1-3% acetone/ CH2Cl2) to produce 117 mg (0.36 mmol; 27%) of 68 as a clear oil.

The chemical industry reduces the impact on the environment during synthesis 120747-84-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SCHERING CORPORATION; WO2008/108957; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Aminopyrimidine-5-carbaldehyde

General procedure: To a solution of amine and TEA in the indicated solvent is added acyl chloride dropwise at room temperature. After stirring for 16 hours, the mixture is concentrated.Following Procedure A using isonicotinoyl chloride (2.76 g, 19.. 5 rnmoi). dioxane (20 mL), 10 (800 mg, 6.5 mmol). and TEA (5.42 ml, 39 mmoi), react at 100 C and then dilute the mixture with EA (20 rnL), wash with water (30 mL) and brine (50 mL), concentrate, and purify with silica gel column chromatography (MeOH:DCM == 1:50) to give 27 as a white solid (400 mg, 27% yield). (MS: [M+H] 229.1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 120747-84-4, 2-Aminopyrimidine-5-carbaldehyde.

Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Aminopyrimidine-5-carbaldehyde

General procedure: To a solution of amine and TEA in the indicated solvent is added acyl chloride dropwise at room temperature. After stirring for 16 hours, the mixture is concentrated.Following Procedure A using isonicotinoyl chloride (2.76 g, 19.. 5 rnmoi). dioxane (20 mL), 10 (800 mg, 6.5 mmol). and TEA (5.42 ml, 39 mmoi), react at 100 C and then dilute the mixture with EA (20 rnL), wash with water (30 mL) and brine (50 mL), concentrate, and purify with silica gel column chromatography (MeOH:DCM == 1:50) to give 27 as a white solid (400 mg, 27% yield). (MS: [M+H] 229.1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 120747-84-4, 2-Aminopyrimidine-5-carbaldehyde.

Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 120747-84-4, Adding some certain compound to certain chemical reactions, such as: 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde,molecular formula is C5H5N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 120747-84-4.

Sodium triacetoxy borohydride (883 mg, 4.166 rnmol) was added slowly at 0 C to a solution of (trans)-2-(4-(benzyloxy)phenyl)cyclopropanamine (Intermediate B, 500 mg, 2.083 mmol), 2-aminopyrimidine-5-carbaldehyde (256 mg, 2.083 mmol) in DCE (10 mL) and stirred for 20 h. After completion, the solvent was evaporated. The residue was dissolved in Methanol (15 mL), NaBH4 (237 mg, 6.249 mmol) was added slowly at 0 C and stirred for 3 h. After completion, the solvent was evaporated, the residue was dissolved in ice water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic layers were washed with brine (20 mL) and dried over anhydrous Na2S04; filtered and evaporated. The crude residue was purified by prep HPLC to afford 5-(((tran_?)-2-(4- (benzyloxy)phenyl)cyclopropylamino)methyl)pyrimidin-2-amine (180 mg, 25 %) as white solid. .H-NMR (400 MHz, DMSO-d6) delta (ppm): 0.85 (q, 1H), 0.90 (quin, 1H), 1.73 (m, 1H), 2.07 (m, 1H), 2.75 (brs, 1 H), 3.53 (s, 2H), 5.04 (s, 2H), 6.46 (s, 2H), 6.85 (d, 2H), 6.92 (d, 2H), 7.33 (m, 1H), 7.42 (m, 4H), 8.1 1 (s, 2H). Mass (M+H): 347.3

According to the analysis of related databases, 120747-84-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORYZON GENOMICS S.A.; ORTEGA MUNOZ, Alberto; FYFE, Matthew, Colin, Thor; MARTINELL PEDEMONTE, Marc; TIRAPU FERNANDEZ DE LA CUESTA, Inigo; ESTIARTE-MARTINEZ, Maria de los Angeles; WO2012/13728; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde, molecular formula is C5H5N3O, molecular weight is 123.11, as common compound, the synthetic route is as follows.SDS of cas: 120747-84-4

A solution of aldehyde (50 g, 0.41 mol) [see, for example, WO 0232893] in MeOH (300 mL) was cooled to 0 C. and carefully treated with NaBH4 (20 g, 0.53 mol in 6 batches) over 20 minutes. The reaction was then allowed to warm to 20 C. and was stirred for 4 hours. The mixture was again cooled to 0 C., carefully quenched with saturated aqueous NH4Cl, and concentrated. Flash chromatography (5-10% 7N NH3-MeOH/CH2Cl2) provided the primary alcohol (31 g, 62%) as a light yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,120747-84-4, 2-Aminopyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING CORPORATION; US2005/187219; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 120747-84-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde, molecular formula is C5H5N3O, molecular weight is 123.11, as common compound, the synthetic route is as follows.

5G To a solution of compound 5F (0.41 g, 1.0 mmol) in CH2Cl2 (20 mL) was added a solution of compound 5G (0.31 g, 2.5 mmol, JP Patent 63227573, 1988), NaBH(OAc)3 (0.53 g, 2.5 mmol) and few drops of AcOH and the resulting reaction was allowed to stir for about 15 hours at 20 C. The reaction mixture was partitioned between 10% NaOH and CH2Cl2 and the organic layer was dried with Na2SO4 then concentrated in vacuo. The resulting residue was purified using flash chromatography (0-5% 7N NH3-CH3OH/CH2C12) to provide compound 5 (0.45g, 87%). MS: 516 (M+H).

The chemical industry reduces the impact on the environment during synthesis 120747-84-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SCHERING CORPORATION; WO2008/108958; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 120747-84-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below.

Preparation 3: Step 2: To a mixture of 20 (166 mg, 1.35 [MMOL),] DMAP (17 mg, 0.14 [MMOL)] and Et3N (418 [LLI,] 3.00 [MMOL)] in THF (10 ml) was added (BOC) [20] (589 mg, 2.7 [MMOL).] The mixture was stirred at RT for 5 h, concentrated-dry loaded on silica gel and flash chromatographed (1-3% [ACETONE/CH2CI2)] to produce 21 (117 mg, 0.36 [MMOL] ; 27%) as a clear oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,120747-84-4, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; WO2004/831; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 120747-84-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below.

(0209) To a solution of the compound of Reference Example 1 (30 mg, 0.129 mmol) in dichloromethane (1.5 mL) was added triethylamine (0.036 mL, 0.258 mmol), the mixture was stirred at room temperature for 10 minutes, and then 2-aminopyrimidine-5-carboxyaldehyde (15.9 mg, 0.129 mmol) and sodium triacetoxyborohydride (41.0 mg, 0.194 mmol) were added thereto. The mixture was stirred at room temperature for 1.5 hours, then sodium triacetoxyborohydride (41.0 mg, 0.194 mmol) was added thereto, and the mixture was stirred at room temperature for additional 24 hours. To the reaction mixture was then added saturated aqueous sodium hydrogen carbonate solution (20 mL), and the mixture was extracted with chloroform (20 mL) twice. The combined organic layer was dried over anhydrous sodium sulfate, filtrated, and concentrated. The resulting residue was purified by silica gel column chromatography (chloroform:methanol=100:0 to 90:10) to give the title compound (20.1 mg, 58%). (0210) 1H-NMR (400 MHz, CDCl3) delta: 2.65-2.70 (2H, m), 2.71-2.75 (2H, m), 3.20-3.24 (2H, m), 3.50 (2H, s), 4.99 (2H, brs), 6.60-6.64 (1H, m), 7.13 (1H, ddd, J=7.4, 4.8, 1.0 Hz), 7.37 (1H, d, J=8.0 Hz), 7.63 (1H, ddd, J=7.7, 7.7, 1.8 Hz), 8.30 (2H, s), 8.54-8.57 (1H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,120747-84-4, 2-Aminopyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Sumitomo Dainippon Pharma Co., Ltd.; YOSHINAGA, Hidefumi; URUNO, Yoshiharu; NAGATA, Hidetaka; HASHIMOTO, Masakazu; KATO, Taro; (43 pag.)US2016/122319; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia