Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1208087-83-5, name is 1-(2-Chloropyrimidin-4-yl)piperidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1208087-83-5
To a suspension of the compound obtained in the previous step (8.87 g, 36.7 mmol) in dichloromethane (300 ml) were added Nu,Nu-diisopropylethyl amine (14.23 g, 1 10.1 mmol), 3,5- dimethoxyaniline (16.87 g, 1 10.1 mmol) and TBTU (17.68 g, 55.1 mmol). After stirring for 17h at room temperature the reaction mixture quenched by the addition of a saturated aqueous solution of sodiumbicarbonate and extracted with dicloromethane. The combined organic layers were dried over Na2S04 and evaporated under reduced pressure. The crude product was purified by normal phase chromatography, eluting with Heptane with 50% ethyl acetate to give 1 -(2-chloropyrimidin-4-yl)-N-(3,5-dimethoxyphenyl)piperidine-4-carboxamide (6.99 g) as a white solid
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Reference:
Patent; MSD OSS B.V.; HUISMAN, Ines; VAN DER STELT, Marcelis; WIEDENHOF, Wouter; BAKER-GLENN, Charles, Anthony, Graham; BLACKABY, Wesley, Peter; TRIVEDI, Naimisha; WO2013/41457; (2013); A1;,
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