Category: 1215787-31-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1215787-31-7, name is 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 1215787-31-7

General procedure: To a solution of compound 4 (2.43 g, 0.01 mol) in 25 mL dioxane was added 1-(2,6-Dichloro-3-fluorophenyl)ethan-1-amine (3.12 g, 0.015 mol), and then the reaction mixture was stirred at room temperature overnight. After that, the mixture was poured into 150 mL H2O, and then the resulting precipitate was filtered, washed with 50% ethanol, and dried overnight under vacuum to give 5a as white solid (3.58 g, yield, 86%).

The synthetic route of 1215787-31-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hou, Ju; Wan, Shanhe; Wang, Guangfa; Zhang, Tingting; Li, Zhonghuang; Tian, Yuanxin; Yu, Yonghuan; Wu, Xiaoyun; Zhang, Jiajie; European Journal of Medicinal Chemistry; vol. 118; (2016); p. 276 – 289;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1215787-31-7, name is 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, molecular formula is C7H3BrClN3, molecular weight is 244.4758, as common compound, the synthetic route is as follows.Formula: C7H3BrClN3

Add 24.2 g (0.1 mol) of 4-chloro-6-bromopyrido[2,3-d]pyrimidine, 7.4 g (0.1 mol) of propylenediamine and 400 ml of 1,4-dioxane to a 1 L round bottom flask. The mixture was heated to 60 C, and the reaction was monitored by TLC until the reaction was completed, and the solvent was evaporated to givethe compound 8-1 18.9 g of white solid (yield: 79.8%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1215787-31-7, 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Heilongjiang University Of Traditional Chinese Medicine; Chen Hong; Chen Qun; Li Yan; Liu Yan; Song Qiannan; Wang Lin; Su Yuming; Liu Linlin; Dai Jinzhu; Guo Jianbo; Li Fei; Lu Lu; Guo Wei; (18 pag.)CN109836423; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia