Category: 1220-83-3

Hypothetical scenarios estimating and simulating the fate of antibiotics: Implications for antibiotic environmental pollution caused by manure application was written by Yan, Xiao-Ting;Zhai, Yun-Qiu;Cai, Ya-ya;Guo, Zhao;Zhang, Qian-Qian;Ying, Guang-Guo. And the article was included in Science of the Total Environment in 2022.Recommanded Product: 1220-83-3 This article mentions the following:

The application of animal manure containing antibiotic residues as an organic fertilizer to farmlands, poses a major threat to the health of river basin ecosystems. Waste treatment processes can help reduce antibiotic pollution levels in river basins following manure application, but the overall influence of these processes remains unclear. This study evaluates the impact of manure treatment methods on the emission and subsequent river pollution caused by 14 frequently detected antibiotics in a typical pig breeding area in China, by using hypothetical scenarios method. Three scenarios were constructed based on possible fate pathways of antibiotics, representing in 47.0, 55.3, and 81.6 ton·yr-1 antibiotic emissions into the river basin. The soil and water assessment tool (SWAT) model successfully simulated the transport of antibiotics from farmland to surface water, with calibration and verification performed using hydrol. station monthly data over 8 consecutive years. Field measured concentrations also verified the reliability of the model and were used to determine the most realistic scenario. In basins applied with manure, environmental antibiotic pollution is most affected by the wastewater treatment process and manure applied patterns, followed by changes in streamflow. The antibiotic pollution in manure applied areas showed significant spatial and temporal differences, resulting from the different manure application patterns. The simulated total outflow of antibiotics in the river basin accounted for 18.1% of the inflow, with the loss of target antibiotics by degradation, volatilization and sedimentation deposition in the river basin being 0.23, 0.01 and 33.2 ton·yr-1, resp. This study can help to clarify the environmental fate of antibiotics in the basin following manure application, provide guidance for policy makers and help to design the effective corrective interventions for reducing the environmental pollution. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 1220-83-3).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 1220-83-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In situ application of the diffusive gradients in thin film technique in aquaculture ponds for monitoring antibiotics, hormones, and herbicides was written by Chen, Yiqin;Wen, Ju;Wu, Meng;Li, Juan-Ying;Wang, Qian;Yin, Jie. And the article was included in Environmental Science and Pollution Research in 2022.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

In recent years, as the abuse of antibiotics, hormones, and herbicides has worsened in aquaculture industry, it is important to monitor the concentrations of those trace contaminants in aquaculture water more effortlessly. The aim of this study was to develop a reliable sampling method for chem. monitoring in aquaculture ponds based on the technique of diffusive gradients in thin films (DGT). A binding material (XDA-1 resin) with high adsorption capacity for antibiotics, hormones, and herbicides was selected. In laboratory, the diffusion coefficients of 11 antibiotics, 3 hormones, and 3 herbicides of the XDA-1-DGT devices were tested and ranged from 1.0×10-6 to 8.7×10-5 cm2/s. During the in situ application of XDA-1-DGT devices in different aquaculture ponds, concentrations of 11 antibiotics, 3 hormones, and 3 herbicides in aquaculture water (CSOLN) via grab sampling were also analyzed and found ranging from 0.03 to 6.3 ng/L, lower than the results based on DGT (CDGT) (1.2-1.3×102 ng/L). The values of CDGT/CSOLN were larger than one unit, suggesting that the rates of resupply of target chems. (antibiotics, hormones, and herbicides) by the desorption and diffusion of pond water were higher than the rates of uptake by XDA-1-DGT, and pond water was proved a sufficient reservoir of antibiotics for DGT application. The value of Log (CDGT/CSOLN) of 1.1 derived from the application in the aquaculture ponds of 14 regions in Eastern China can be a reference value for future chem. monitoring based on DGT technique. And the accuracy of this value was found hardly affected by the phys. and chem. properties of chems. with pKa ranging from -1 to 12, Log Kow ranging from 0 to 4.5, and Log solubility ranging from 0.0 to 4.0. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Assessment of veterinary antibiotics from animal manure-amended soil to growing alfalfa, alfalfa silage, and milk was written by Huang, Rongcai;Guo, Zitai;Gao, Shengtao;Ma, Lu;Xu, Jianchu;Yu, Zhongtang;Bu, Dengpan. And the article was included in Ecotoxicology and Environmental Safety in 2021.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:

Using animal manure as organic fertilizer to grow fodder crops is causing public health concerns because animal manure is the major reservoir of veterinary antibiotics. In this study, we used a math. model to estimate the risk of human exposure to veterinary antibiotics when using swine manure as organic fertilizer to grow alfalfa (Medicago sativa L.). Alfalfa was planted in a greenhouse and fertilized with swine manure spiked with oxytetracycline (OTC, at 0, 150, and 1500 mg/kg of manure), ofloxacin (OFL, at 0, 15, and 150 mg/kg), or sulfamonomethoxine (SMM, at 0, 5, 15 and 150 mg/kg). Alfalfa was harvested at the budding stage and ensiled for 60 days. Results showed that OTC and OFL could be detected in the alfalfa root, stem, and leaf with a concentration ranging from 8.85 to 59.17 μg OTC /kg and from 1.50 to 4.10 μg OFL/kg dry matter, but SMM could only be detected in the root ranging from 29.10 to 63.75 μg/kg dry matter. The ensiling for 60 days decreased the OFL concentration by 68.7% but only slightly decreased the OTC concentration The maximum daily exposures of humans to OTC and OFL through liquid milk consumption were estimated to be 5.84E-8 and 1.63E-8 μg, resp., both of which are well below the intake levels of OTC (72 μg) and OFL (54 μg) mandated by the European Union. The results of the present study indicate that using swine manure as organic fertilizer to grow alfalfa poses a limited risk for human exposure to veterinary antibiotics through the consumption of liquid milk. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Safety of 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Evaluation of growth and biochemical responses of freshwater microalgae Chlorella vulgaris due to exposure and uptake of sulfonamides and copper was written by Li, Shuangxi;Yu, Yunjiang;Gao, Xinxin;Yin, Zhihong;Bao, Jianfeng;Li, Zhuo;Chu, Ruoyu;Hu, Dan;Zhang, Jin;Zhu, Liandong. And the article was included in Bioresource Technology in 2021.COA of Formula: C11H12N4O3S This article mentions the following:

Sulfonamides (SAs) and heavy metals are frequently detected together in livestock wastewater. In this study, evaluations regarding their potentially adverse effects on microalgae and according removals were investigated. Results showed that the growth of C. vulgaris was inhibited by SAs and Cu. There was an obvious recovery period in photosynthetic activity (Fv/Fm), indicating that the damage to the photosystem of microalgae was reversible. The co-existence of SAs and Cu significantly affected the biochem. characteristics, including the activities of antioxidant enzyme and the contents of photosynthetic pigments, proteins and polysaccharides. The addition of Cu obviously promoted the removal efficiencies of SMZ, SMX and SMM, which might be ascribed to the bridging effect of Cu in the bioadsorption of SAs. This study is conducive to understand the changes in the biochem. responses of microalgae under the combined impacts of SAs and Cu, and provides a new insight for the simultaneous removals. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3COA of Formula: C11H12N4O3S).

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.COA of Formula: C11H12N4O3S

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia