Category: 1240390-28-6

Electric Literature of 1240390-28-6, Adding some certain compound to certain chemical reactions, such as: 1240390-28-6, name is 2,4-Dichloropyrimidine-5-carboxylic acid amide,molecular formula is C5H3Cl2N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1240390-28-6.

General procedure: Procedure B: A mixture of substituted 2,4-dichloropyrimidine (1.0 equiv.), and substituted aniline (1.0-1.05 equiv.), and DIPEA (1.2 equiv.) in isopropanol (0.1 M) was stirred and heated at reflux. The reaction time, work-up, and product isolation procedure are described below.

According to the analysis of related databases, 1240390-28-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas, J.; LAWRENCE, Harshani, R.; (257 pag.)WO2016/22460; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1240390-28-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1240390-28-6, name is 2,4-Dichloropyrimidine-5-carboxylic acid amide, molecular formula is C5H3Cl2N3O, molecular weight is 192.0028, as common compound, the synthetic route is as follows.

4-(tert-Butylamino)-2-chloropyrimidine-5-carboxamide A mixture of 2,4-dichloro-pyrimidine-5-carboxamide (10.0 g), DIPEA (11 mL) in NMP (30 mL) were stirred at 25 C. tert-Butylamine (6.6 mL) was charged to the mixture, and the mixture was stirred at 25 C. for 16 h. Water (100 mL) was added to the mixture at 25 C. The mixture was stirred for 1 h. The suspension was filtered, washed with water (50 mL) and dried in a vacuum oven at 40 C. with a nitrogen bleed for 24 h to give 4-(tert-butylamino)-2-chloropyrimidine-5-carboxamide as a white solid (8.7 g, 84%). 1H NMR (DMSO-d6) delta 9.41 (s, 1H), 8.55 (s, 1H), 8.19 (s, 1H), 7.67 (s, 1H), 1.42 (s, 9H).

Statistics shows that 1240390-28-6 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloropyrimidine-5-carboxylic acid amide.

Reference:
Patent; Ferretti, Antonio Christian; Man, Hon-Wah; Muslehiddinoglu, Jale; Xu, Jean; Yong, Kelvin Hin-Yeong; Beauchamps, Marie Georges; Kothare, Mohit Atul; Zou, Nanfei; Boersen, Nathan Andrew; Li, Ying; Ye, Ying; US2015/210650; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1240390-28-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1240390-28-6, name is 2,4-Dichloropyrimidine-5-carboxylic acid amide. This compound has unique chemical properties. The synthetic route is as follows.

4-(Bicyclo [1.1.1] pentan-l-ylamino)-2-chloropyrimidine-5-carboxamide : A mixture of 2,4-dichloro-pyrimidine-5-carboxamide (2 g), bicyclo[l.l.l]pentan-l-amine hydrochloride (1.18 g), sodium bicarbonate (1.75 g), and NMP (10 mL) was stirred at 25 C for 24 h. Water (10 mL) was charged maintaining the reaction temperature less than 30 C, and the mixture was stirred at 25 C for 2 h. The suspension was filtered, and washed with NMP: water (1 : 1 10 mL), then water (2X10 mL), and dried in a vacuum oven at 40 C with nitrogen sweep to give 4-(bicyclo[l .l . l]pentan-l-ylamino)-2-chloropyrimidine-5 -carboxamide as a white solid (1.97 g, 83 %yield). 1H NMR (DMSO-d6) delta 2.14 (s, 6H), 2.51-2.53 (m, 1H), 7.76 (br. s., 1H), 8.23 (br. s., 1H), 8.60 (s, 1H), 9.57 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1240390-28-6, 2,4-Dichloropyrimidine-5-carboxylic acid amide.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; FERRETTI, Antonio Christian; MAN, Hon-Wah; MUSLEHIDDINOGLU, Jale; XU, Jean; YONG, Kelvin Hin-yeong; BEAUCHAMPS, Marie Georges; KOTHARE, Mohit Atul; ZHOU, Nanfei; BOERSEN, Nathan Andrew; LI, Ying; HILGRAF, Robert; NAGY, Mark A.; ZOU, Daozhong; HUANG, Lianfeng; WO2015/116755; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia