Category: 1245506-61-9

Electric Literature of 1245506-61-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1245506-61-9, name is 2-Chloro-5-methoxy-4-methylpyrimidine. A new synthetic method of this compound is introduced below.

To a -78 C solution of Intermediate 3B (1.60 g, 10.09 mmol) in DCM (20 mL) was added BBr3 (3.82 mL, 40.4 mmol) dropwise. The reaction mixture was allowed to slowly warm to RT and stirred for 16 h at RT, then was cautiously quenched with satd aq. NaHC03 (pH adjusted to ~4) and partitioned between EtOAc and water. The aqueous phase was extracted with EtOAc (2x); the combined organic layers were dried (MgS04) and concentrated in vacuo. The crude product was chromato graphed (40 g S1O2; continuous gradient from 0-100% EtOAc in Hexane over 15 min) to afford the title compound (1.33 g, 9.20 mmol, 91 % yield) as a white solid. NMR (400 MHz, DMSO- d6) d 10.63 (s, 1H), 8.11 (s, 1H), 2.34 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1245506-61-9, 2-Chloro-5-methoxy-4-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SHI, Yan; WANG, Ying; CHENG, Peter Tai Wah; LI, Jun; WALKER, Steven J.; (147 pag.)WO2019/126089; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1245506-61-9, name is 2-Chloro-5-methoxy-4-methylpyrimidine. A new synthetic method of this compound is introduced below., Product Details of 1245506-61-9

General procedure: To a solution of 2-methoxy-5-methylpyridin-3-yl acetate (5.80 g, 32.0 mmol) in anhydrous CH2Cl2 (50 mL) was added with N-bromosuccinimide (5.69 g, 32.0 mmol) and AIBN (530 mg, 3.23 mmol). The reaction mixture was heated at reflux for 24 h, added with N-bromosuccinimide (1.14 g, 6.41 mmol), further heated at reflux for 18 h, and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, hexane ramping to CH2Cl2:hexane = 1:1) to give 9 as a colourless liquid (3.88 g, 47%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1245506-61-9, 2-Chloro-5-methoxy-4-methylpyrimidine.

Reference:
Article; Long, Yi; Yu, Mingfeng; Li, Peng; Islam, Saiful; Goh, Aik Wye; Kumarasiri, Malika; Wang, Shudong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5674 – 5678;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1245506-61-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1245506-61-9, name is 2-Chloro-5-methoxy-4-methylpyrimidine, molecular formula is C6H7ClN2O, molecular weight is 158.59, as common compound, the synthetic route is as follows.

(2) 2-Chloro-4-methylpyrimidin-5-ol (Prep 1-2)A dichloromethane solution (50 ml) of the compound Prep 1-1 (6.6 g) was added dropwise to a dichloromethane solution (1.0 M: 100 ml) of boron tribromide, and the obtained mixture was then stirred at room temperature for 4 days. Thereafter, methanol was added to the reaction mixture, and a 5 N sodium hydroxide aqueous solution was then added to the reaction solution for neutralization. Liquid separation and extraction were carried out successively using chloroform and ethyl acetate at a pH value of approximately pH 2 to 3. The organic layer was dried over magnesium sulfate, and the solvent was then concentrated under reduced pressure. Diethyl ether was added to the obtained residue to solidify it, and the solidified product was collected by filtration and was then dried, so as to obtain the title compound.1H-NMR (400 MHz, DMSO-d6) delta (ppm): 2.32 (s, 3H), 8.09 (s, 1H), 10.61 (s, 1H).

The chemical industry reduces the impact on the environment during synthesis 1245506-61-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; US2012/95031; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1245506-61-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1245506-61-9, name is 2-Chloro-5-methoxy-4-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a -78 C solution of Intermediate 3B (1.60 g, 10.09 mmol) in DCM (20 mL) was added BBr3 (3.82 mL, 40.4 mmol) dropwise. The reaction mixture was allowed to slowly warm to RT and stirred for 16 h at RT, then was cautiously quenched with satd aq. NaHC03 (pH adjusted to ~4) and partitioned between EtOAc and water. The aqueous phase was extracted with EtOAc (2x), and the combined organic layers were dried (MgS04) and concentrated in vacuo. The crude product was chromatographed (40 g S1O2; continuous gradient from 0-100% EtOAc in Hexane over 15 min) to afford the title compound (1.33 g, 9.20 mmol, 91 % yield) as a white solid. NMR (400 MHz, DMSO- d6) d 10.63 (s, 1H), 8.11 (s, 1H), 2.34 (s, 3H).

According to the analysis of related databases, 1245506-61-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SHI, Yan; CHENG, Peter Tai Wah; ZHANG, Hao; LI, Jun; FANG, Tianan; CORTE, James R.; (135 pag.)WO2019/126103; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia