Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1256353-15-7, name is 8-Bromopyrido[4,3-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1256353-15-7
Step B: 8-Bromopyrido[4,3-]pyrimidin-4-ol (0.82 g, 3.62 mmol) was suspended in thionyl chloride (36 mL) and DMF was added (0.28 mL, 3.62 mmol). The reaction mixture was stirred at reflux for 5 hours and then concentrated under reduced pressure. Toluene was added, and the mixture was re-concentrated in vacuo (repeated twice) to afford crude 8-bromo-4- chloropyrido[4,3-d]pyrimidine (0.89 g, quantitative yield) which was used in the next step without further purification.
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Reference:
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; ALIAGAS, Ignacio; GRADL, Stefan; GUNZNER, Janet; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim; WEN, Zhaoyang; ZHAO, Guiling; BUCKMELTER, Alexandre J.; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen; MORENO, David; REN, Li; WENGLOWSKY, Steven Mark; WO2011/25938; (2011); A2;,
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