Synthetic Route of 126728-20-9 ,Some common heterocyclic compound, 126728-20-9, molecular formula is C7H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2,4-Dichloropyrido[2,3-d]pyrimidine (170.0 mg, 0.85 mmol) and 2-(4-nitrophenyl)ethan-1-amine hydrochloride (172.0 mg, 0.85 mmol) were dissolved in iPrOH (8.5 mL), and Et3N (250.0 muL, 1.80 mmol) was added thereto at room temperature. The reaction mixture was stirred at 21C for 5 hours and distilled under reduced pressure. After addition of CH2Cl2and water, the residue was stirred. The obtained solid was filtered and dried to obtain the white solid compound, 2-chloro-N-(4-nitrophenethyl)pyrido[2,3-d]pyrimidin-4-amine (250.0 mg, 89%).[735][736]1H NMR (300 MHz, DMSO-d6) delta = 9.15 (t,J= 5.3 Hz, 1H), 8.97 (d,J= 2.7 Hz, 1H), 8.71 – 8.61 (m, 1H), 8.20 – 8.12 (m, 2H), 7.62 – 7.52 (m, 3H), 3.86 – 3.74 (m, 2H), 3.17 – 3.06 (m, 2H)[737]LC/MS ESI (+): 330 (M+1)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 126728-20-9, 2,4-Dichloropyrido[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; C&C RESEARCH LABORATORIES; PARK, Chan Hee; IM, Jun Hwan; LEE, Soon Ok; LEE, Sang Hwi; KO, Kwang Seok; KIM, Byung Ho; MOON, Hyung Jo; KIM, Jae Ill; PARK, Heon Kyu; HONG, Yeon Ju; (0 pag.)WO2019/231271; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia