Category: 13036-50-5

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13036-50-5, name is 2-Chloro-4-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-4-phenylpyrimidine

A solution of 2-chloro-4-phenylpyrimidine (245 mg, 0.59 mmol), 2-amino-N,N-dimethylpropanamide hydrochloride (294 mg, 1.93 mmol) and DIPEA (0.673 mL, 3.86 mmol) in acetonitrile (2.0 mL) was heated to 100 C for 16 h. The reaction mixture was concentrated and dissolved in ethyl acetate (15 mL) and washed with water (3 x 10 mL). The aqueous layers were then combined and washed with ethyl acetate (2 x 15 mL). The organic layers were combined and concentrated in vacuo. The crude material was purified using silica chromatography with a gradient of 0-100 % (3:1 ethyl acetate:ethanol + 1 % triethylamine)/cyclohexane. The relevant fractions were combined and concentrated in vacuo to yieldN,N-dimethyl-2-((4-phenylpyrimidin-2-yl)amino)propanamide (238 mg, 0.880 mmol, 69% yield) as a white powder. LCMS (High pH, ES+ ): tR = 0.92 min, [M+H]+ 271.2. 1H NMR (400 MHz, CDCl3) delta 1.45 (d, J = 6.8 Hz, 3H), 3.01 (s, 3H), 3.17 (s, 3H), 5.15 (qd, J=6.8, 5.1 Hz, 1H), 6.05 (d, J=5.1 Hz, 1 H), 6.98 (d, J = 5.31 Hz, 1H), 7.43-7.49 (m, 3H), 7.96-8.03 (m, 2H), 8.33 (d, J = 5.3 Hz, 1H). 13C NMR (101 MHz, CDCl3) delta 18.4, 35.9, 37.1, 46.8, 106.9, 127.0, 128.7, 130.5, 137.5, 158.6, 161.6, 173.3. HRMS: (C15H18N4O) [M+H]+ requires 271.1553, found [M+H]+ 271.1553. numax (neat): 3257, 1654, 1563, 1530, 1412, 767, 695, 656, 628 cm-1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 13036-50-5, 2-Chloro-4-phenylpyrimidine.

Reference:
Article; Law, Robert P.; Ukuser, Sabri; Tape, Daniel T.; Talbot, Eric P. A.; Synthesis; vol. 49; 16; (2017); p. 3775 – 3793;,
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Pyrimidine – Wikipedia

Application of 13036-50-5 ,Some common heterocyclic compound, 13036-50-5, molecular formula is C10H7ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2,4-dichloropyrimidine (149 mg, 1 mmol) in THF (5 mL), tetrakis (triphenylphosphine) palladium (23 mg, 2 mol%) and 0.5M solution of phenylzinc bromide (2.1 mL, 1.05 mmol) in THF were added. The reaction mixture was stirred at50 C for overnight. Then it was added saturated ammonium chloride solution and extracted with EtOAc twice. The organic layers were combined, washed with water and dried(MgS04). Evaporation of solvent gave a yellow residue which was purified by Prep. HPLC to afford a yellowish oil as 2-chloro-4-phenyl- pyrimidine to carry on. To a solution of intermediate 2 (20 mg, 0.039 mmol) in DMF (3 mL), NaH (3.9 mg of 60% dispersion in mineral oil, 0.0975 mmol) was added at0 C. The reaction mixture was then warmed to rt. and stirred for 1 hr. Then 2-chloro-4-phenyl- pyrimidine prepared above (18 mg as crude) was added. The reaction mixture was stirred at rt. for overnight. It was then quenched with water and extracted with EtOAc. The organic layer was separated, washed with brine and dried(MgS04). Evaporation of solvent gave yellowish oil which was then purified by Prep. HPLC to give a thick colorless oil as final product (Compound 335) as TFA salt. (5.5 mg, 18% yield) ‘H NMR (CD30D, 300 MHz) 0.92-1. 12 (m, 11 H). 1.25 (m, 2 H), 1.44 (dd, J=9. 2, 5.5 Hz,1 H), 1.89 (dd, J=8. 1,5. 5 Hz, 1H), 2.17-2. 37 (m, 2 H), 2.57 (m, 1 H), 2.95 (m,1 H), 3.52 (s, 3 H), 4.14 (m,1 H), 4.24-4. 38 (m, 2 H), 4.51 (m,1 H), 5.13 (d, J=10. 2 Hz,1 H), 5.31 (d, J=17. 2 Hz,1 H), 5.77 (m,1 H), 5.86 (s,1 H), 7.48-7. 60 (m,3 H), 7.66 (d, J=5.3 Hz, 1 H), 8.18 (m,2 H), 8.60 (d, J=5.1 Hz, 1 H). LC-MS (retention time: 1.947 min. ), MS m/z 669(MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13036-50-5, 2-Chloro-4-phenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99274; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13036-50-5, name is 2-Chloro-4-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 13036-50-5

To a solution of compound 1-2 (1.00 g, 6.60 mmol, 1.00 eq) and 2-chloro-4-phenyl-pyrimidine (1.26 g, 6.60 mmol, 1.00 eq) in EtOH (20.00 mL) were added DIPEA(2.56g, 19.80 mmol, 3.46mL, 3.00 eq) and Na2CO3(2.10g, 19.80 mmol, 3.00 eq) at room temperature. The reaction mixture was heated to 40C and stirred for 12 h. Then the solvent was removed by rotary evaporation under reduced pressure, and the residue was diluted with water (20 mL) and then extracted with ethyl acetate. The organic phases were combined, washed with a saturated saline solution, dried over anhydrous sodium sulfate, filtered, and then concentrated. The resulting residue was separated by preparative chromatography (mobile phase: petroleum ether/ethyl acetate = 5/1) to afford compound 2-2. MS (ESI) m/z: 269.9 [M+1].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 13036-50-5, 2-Chloro-4-phenylpyrimidine.

Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; XIONG, Jian; XIE, Cheng; CHEN, Kevin X; XU, Xiongbin; ZHANG, Xuejin; GONG, Zhen; LI, Jian; CHEN, Shuhui; ZHANG, Aiming; JIANG, Zhulian; ZHANG, Xiquan; TIAN, Xin; EP3590944; (2020); A1;,
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Pyrimidine – Wikipedia

Reference of 13036-50-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13036-50-5, name is 2-Chloro-4-phenylpyrimidine. A new synthetic method of this compound is introduced below.

A mixture of 2-chloro-4-phenylpyrimidine (71 mg, 0.37 mmol), Intermediate 20 (100 mg, 0.34 mmol) and DIPEA (120 muIota_, 0.68 mmol) in NMP (1 mL) was heated at 130C for 3 hrs. The reaction mixture was allowed to cool to ambient temperature and diluted with water (10 mL). The crude product was extracted into diethyl ether (20 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by chromatography on the Biotage Companion (12 g column, 0 to 100% diethyl ether in isohexane) to afford the title compound as a gum (65 mg). LCMS (Method A): Two peaks at 2.45 min and 2.66 min, 451 [M+H]+.1H NMR (400 MHz, DMSO-d6, 374 K) 8.36 (d, 0.8 H), 8.30 (bd, 0.2 H), 8.15-8.07 (m, 1 .6 H), 7.97 (bm, 0.3 H), 7.56-7.46 (m, 3.92 H), 7.46-7.24 (m, 7.38 H), 7.16-7.05 (m, 1.8 H), 6.33 (bs, 1 H), 4.41 (td, 1 H), 3.71 (m, 1 H), 3.50 (m, 1 .1 H), 3.26 (bm, 0.2 H), 2.84 (s, 0.3 H), 2.82 (s, 0.3 H), 2.63 (s, 0.3 H), 2.48 (s, 2.1 H), 1 .82 (bm, 0.7 H), 1.00 (d, 2.5 H), 0.78 (bd, 0.5 H), 0.56 (bs, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13036-50-5, 2-Chloro-4-phenylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; C4X DISCOVERY LIMITED; BLANEY, Emma Louise; MARTIN, Barrie Phillip; NOWAK, Thorsten; WATSON, Martin John; (212 pag.)WO2016/34882; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 13036-50-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13036-50-5 as follows.

To the obtained 2-chloro-4-phenylpyrimidine was added concentrated hydrochloric acid (~10 N) and stirred well. The homogeneous mixture was refluxed for 1 hour. The reaction mixture was poured into 10% aqueous sodium carbonate solution. The white precipitate was filtered off and dried to give a white solid. TLC was observed at Rf: 02 (chloroform: methanol (9.5: 0.5)).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13036-50-5, its application will become more common.

Reference:
Patent; CHUNGNAM NATIONAL UNIVERSITY INDUSTRY & ACADEMIC COOPERATION (IAC); JUNG, SANG HUN; WOO, SUN HEE; KIM, SANG KYUM; JEON, EUN SEOK; LEE, YOU JUNG; MANICKAM, MANOJ; JALANI HITESHKUMAR, HITESHKUMAR; SHARMA, NITI; (234 pag.)KR2015/111825; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 13036-50-5, Adding some certain compound to certain chemical reactions, such as: 13036-50-5, name is 2-Chloro-4-phenylpyrimidine,molecular formula is C10H7ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13036-50-5.

To the obtained 2-chloro-4-phenylpyrimidine was added concentrated hydrochloric acid (~ 10 N) and stirred well. The homogeneous mixture was refluxed for 1 hour. The reaction mixture was poured into 10% aqueous sodium carbonate solution. The white precipitate was filtered off and dried to give a white solid. TLC was observed at R f: 02 (chloroform: methanol (9.5: 0.5))

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13036-50-5, 2-Chloro-4-phenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Industry & Academic Cooperation in Chungnam National University (IAC); Jung, Sang-Hun; Woo, Sun-Hee; Kim, Sang- Kyum; Jeon, Eun-Seok; Lee, Yu-Jung; Meunikam, Manoj; Jalani, Hiteshkumar; Sharma, Niti; (205 pag.)KR2016/108281; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 13036-50-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13036-50-5, name is 2-Chloro-4-phenylpyrimidine, molecular formula is C10H7ClN2, molecular weight is 190.629, as common compound, the synthetic route is as follows.

Example 37 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetamidePart I: 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetic acidGeneral Procedure I: Microwave assisted halogen displacement with amino group [0166] A mixture of 2-chloro-4-phenylpyrimidine (0.19 g, 1.0 mmol), 2-(4- aminophenyl)acetic acid (0.38 g, 2.5 mmol), diisopropylethylamine (0.38 mL, 2.0 mmol), THF (3.0 mL) and water (1.0 mL) was placed in a seal tube and heated up to 160C in a microwave (Biotage, Model: Initiator) for 1O h. The reaction mixture was diluted with ether and washed with brine. The organic layer was separated, dried (MgSO4), and concentrated to afford 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetic acid in 77% yield. MS (ESI) 306 (M+H).

Statistics shows that 13036-50-5 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-phenylpyrimidine.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/32861; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 13036-50-5 , The common heterocyclic compound, 13036-50-5, name is 2-Chloro-4-phenylpyrimidine, molecular formula is C10H7ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Man erhitzte 0, 80 g (4, 20 MMOL) 2-CHLOR-4-PHENYLPYRIMIDIN AUS BEISPIEL 24. 1 in 3, 20 ml konz. HCI 1 Stunde auf 100 C. Anschliessend engte man den Ansatz ein, suspendierte ihn in Methylenchlorid und engte erneut ein. Ausbeute : 0, 83 g. ESI-MS : 174, 3, [M+H+] = 173, 2 ;

The synthetic route of 13036-50-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT GMBH & CO. KG; WO2004/80981; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 13036-50-5, Adding some certain compound to certain chemical reactions, such as: 13036-50-5, name is 2-Chloro-4-phenylpyrimidine,molecular formula is C10H7ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13036-50-5.

Preparation of Compound 48 [132] After Compound 2-6 (0.75 g, 3.9 mmol), Compound 2-5 (2.53 g, 4.7mmol), Tetrakis(triphenylphosphine)palladium (0.23 g, 0.2 mmol), potassium carbonate (1.31 g, 9.4 mmol) and ethanol (50 mL) were dissolved in toluen (150 mL), the mixture was stirred under reflux for 5 hours at 120 . After extracting with EA/H2O, drying an organic layer with MgSO4, and removing a solvent by the rotary type evaporator, Compound 48 (0.76 g, 30%) was obtained via column separation.

According to the analysis of related databases, 13036-50-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.; KIM, Hye Mi; KIM, Young Gil; CHO, Young Jun; KWON, Hyuck Joo; KIM, Bong Ok; KIM, Sung Min; WO2011/93609; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia