Category: 130838-36-7

Synthetic Route of 130838-36-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130838-36-7, name is 2,6-Dichloropyrimidine-4,5-diamine. This compound has unique chemical properties. The synthetic route is as follows.

This compound was synthesized in two steps starting from 2,6-dichloropyrimidine-4,5-diamine 5 (Axon MedChem BV, Groningen, Netherlands), according to the procedure described by Baenteli R.et al. [22]. Briefly, a sealed microwave vial was charged with a solution of 5 (400 mg, 2.25 mmol) in EtC(OEt)3 (8 mL) and heated at 160 C for 1 h. After cooling to RT, Et2O (10 mL) was added and the mixture was placed in an ice bath for 1 h. The intermediate product was filtered off and rinsed with ice-cold Et2O (10 mL). The solid wasadded to a sealed microwave vial charged with a mixture of NMP and t-BuNH2 (10 mL; 1/4 v:v), and the mixture was heated at 160 C for 2 h. After cooling to RT, the reaction mixture was partitioned between a saturated NaHCO3 aqueous solution (10 mL) and EtOAc (10 mL). Layers were separated and the aqueous layer was extractedwith EtOAc (2 20 mL). The combined organic layers were washed with brine (10 mL), dried over MgSO4 and concentrated under vacuum to an oily residue. Purification by flash chromatography (SiO2, DCM/MeOH, 98/2) yielded compound 6a (250 mg, 44%) as a white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130838-36-7, 2,6-Dichloropyrimidine-4,5-diamine.

Reference:
Article; Daumar, Pierre; Zeglis, Brian M.; Ramos, Nicholas; Divilov, Vadim; Sevak, Kuntal Kumar; Pillarsetty, Nagavarakishore; Lewis, Jason S.; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 769 – 781;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 130838-36-7, name is 2,6-Dichloropyrimidine-4,5-diamine, the common compound, a new synthetic route is introduced below. Recommanded Product: 130838-36-7

4, 5-Diamino-1,6-DICHLOROPYRIMIDINE (0,55MMMOL), prepared as described in Example 16, was suspended in water (2 ml) and heated to dissolve. After cooling the solution in the ice-water bath, acetic acid (2ml) was added to the solution. Sodium nitrite in water (0,5 MOL/1-2 ml) was added to this stirred solution at 0C during 15 minutes. After next 20 minutes in the ice-water bath, the reaction mixture was etracted with diethyl ether. The etheric solution was neutralized and dried and then evaporated to give the crude product (100%). This product was purified by crystallization from absolute diethyl ether. Yield= 47% m. p. 260C. TLC (I, 12: 2: 1). RF= 0,22. MS: 188,0 (100%, M-H+), 190,0 (65 %, M-H+)

The synthetic route of 130838-36-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSTITUTE OF EXPERIMENTAL BOTANY ASCR; WO2004/18473; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.130838-36-7, name is 2,6-Dichloropyrimidine-4,5-diamine, molecular formula is C4H4Cl2N4, molecular weight is 179.0074, as common compound, the synthetic route is as follows.Quality Control of 2,6-Dichloropyrimidine-4,5-diamine

A suspension of 2,6-dichloropyrimidine-4,5-diamine (16b) (4.4 g, 24.58 mmol) in water (47 ml) was heated and the solid was dissolved. The solution was cooled to 0 C and acetic acid (94 ml) was added, followed by addition of a solution of sodium nitrite (3.05 g, 44.3 mmol) in water (47 mL) during a period of 15 mm. The reaction mixture was stirred at 0 C for another 20 mm and then was extracted with EtOAc. The organics were neutralized, dried and concentrated, the crude product was purified by column chromatography (petroleum ether/ethyl acetate: from 3:1 to 2:1) to provide the title compound (16c) (3.4 g, 72.8%) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,130838-36-7, 2,6-Dichloropyrimidine-4,5-diamine, and friends who are interested can also refer to it.

Reference:
Patent; ORIC PHARMACEUTICALS, INC.; DU, Xiaohui; EKSTEROWICZ, John; FANTIN, Valeria R.; JACKSON, Erica L.; SUN, Daqing; YE, Qiuping; MOORE, Jared; ZAVOROTINSKAYA, Tatiana; (262 pag.)WO2019/90111; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia