Category: 1312535-78-6

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1312535-78-6, name is 1-(2-Chloropyrimidin-4-yl)ethanone, molecular formula is C6H5ClN2O, molecular weight is 156.5697, as common compound, the synthetic route is as follows.HPLC of Formula: C6H5ClN2O

Step 1 : l-(2-chloropyrimidin-4-yl)ethanone (1 eq) is disolved in HBr/HOAc(1 mL/ mmol) and E¾ (1.1 eq) is added drop wise. The reaction mixture is stirred for 1 hour at room temperature, ether (10 mL/mmol) was added and the mixture was cooled at 0 C. The solid is collected by filtration to afford 2-bromo-l-(2-chloropyrimidin-4-yl)ethanone.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1312535-78-6, 1-(2-Chloropyrimidin-4-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; SELEXAGEN THERAPEUTICS, INC.; VERNIER, Jean-michel; HOPKINS, Stephanie; BOUNAUD, Pierre-Yves; O’CONNOR, Patrick; MATTHEWS, David; BENDER, Steve; WO2012/125981; (2012); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1312535-78-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1312535-78-6, name is 1-(2-Chloropyrimidin-4-yl)ethanone, molecular formula is C6H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of l-(2-chloropyrimidin-4-yl)ethanone 2 (1.0 g, 6.4 mmol) in acetic acid (15.0 mL), bromine (0.3 mL, 6.4 mmol) and HBr (47%, 0.7 mL, 6.4 mmol) were added. The resulting mixture was stirred at room temperature for 6h. After completion of the reaction, solvent was distilled off, and the residue obtained was washed with diethyl ether to afford INT- 27 (0.7 g, 46%) as a light brown solid. 1H NMR (400 MHz, CDC13+ DMSO-d6) delta 4.68 (s, 2H), 8.86 (d, J = 4.9 Hz, 1H), 8.80 (d, J = 4.8 Hz, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1312535-78-6, 1-(2-Chloropyrimidin-4-yl)ethanone.

Reference:
Patent; CELGENE AVILOMICS RESEARCH, INC.; ALEXANDER, Matthew David; MCDONALD, Joseph John; NI, Yike; NIU, Deqiang; PETTER, Russell C.; QIAO, Lixin; SINGH, Juswinder; WANG, Tao; ZHU, Zhendong; WO2014/149164; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia