Category: 13162-43-1

Adding a certain compound to certain chemical reactions, such as: 13162-43-1, 4,6-Dichloro-2-methyl-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 13162-43-1, blongs to pyrimidines compound. SDS of cas: 13162-43-1

General procedure: 10% Pd/C(0.05) gwas added to the solution of substituted pyrimidine (4.48mmol) in ethyl acetate (EA, 20mL) in Parr hydrogenater. Then, replace the air with nitrogen three times, and react for 4hat room temperature in normal pressure. Filter the solution to remove Pd/C through Celite filter agent, the filtrate was concentrated to yield the intermediates 11a,b [46]. 5.4.1 4,6-Dichloro-2-methyl-5-nitropyrimidine (11a) Pale solid; Yield: 84.0%; MS (ESI) m/z: 177.94 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13162-43-1, 4,6-Dichloro-2-methyl-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Huang, Daowei; Huang, Lei; Zhang, Qingwei; Li, Jianqi; European Journal of Medicinal Chemistry; vol. 140; (2017); p. 212 – 228;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 13162-43-1 ,Some common heterocyclic compound, 13162-43-1, molecular formula is C5H3Cl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 4,6-dichloro-2-methyl-5-nitropyrimidine (3; J. Chem. Soc. 1954, 3836) (2.23 g, 11 mmol) in EtOH (30 mL) at -30 C. was treated with 1-ethylpropylamine (870 mg, 10 mmol) in EtOH (8 mL) and the reaction mixture was stirred at -30 C. for 1 hour and then warmed to ambient temperature. Volatiles were evaporated and the residue was partitioned between water and EtOAc. The organic layer was dried (sodium sulfate), evaporated, purified by flash chromatography (silica) to give compound (4).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13162-43-1, its application will become more common.

Reference:
Patent; Neurocrine Biosciences, Inc.; US6348466; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia