Category: 1316216-05-3

Adding a certain compound to certain chemical reactions, such as: 1316216-05-3, Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate, blongs to pyrimidines compound. Application In Synthesis of Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate

0128] 2N NaOH (200 mL) was added to a solution of intermediate 3 (3.0 g, 9.4 mmol) in EtOH (200 mL). The mixture was stirred at 60C for 30 min. After evaporation of the solvent, the solution was neutralized with 2N HCl to give a white precipitate. The suspension was extracted with EtOAc (2 x 200 mL) and the organic layer was separated, washed with water (2 x 100 mL), brine (2 x 100 mL) and dried over Na2SO4. Removal of solvent gave a brown solid (2.5 g, 92%).

The synthetic route of 1316216-05-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; Golonzhka, Olga; Jarpe, Matthew B.; (30 pag.)US2017/114023; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1316216-05-3, Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate, blongs to pyrimidines compound. Quality Control of Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate

2N NaOH (200 ml) was added to a solution of compound 3 (3.0 g, 9.4 mmol) in EtOH (200 ml). The mixture was stirred at 60 C for 30min. After evaporation of the solvent, the solution was neutralized with 2N HCl to give a white precipitate. The suspension was extracted with EtOAc (2 chi 200 ml), and the organic layers were separated, washed with water (2 chi 100 ml), brine (2 chi 100 ml), and dried over Na2SO4. Removal of the solvent gave a brown solid (2.5 g, 92 %).

The synthetic route of 1316216-05-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.,; ACETYLON PHARMACEUTICALS, INC.,; WONG, Kwok-kin; LIU, Yan; ADEEGBE, Dennis, O.; QUAYLE, Steven, Norman; (97 pag.)WO2017/214565; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia