Category: 131860-97-4

Synthetic Route of 131860-97-4, Adding some certain compound to certain chemical reactions, such as: 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate,molecular formula is C15H13ClN2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131860-97-4.

A slurry containing methyl (£)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (80.9g at 99%, 0.25mols), potassium carbonate (52.8g at 98%, 0.375mols) and 2- cyanophenol (33.6g at 97.5%, 0.275mols) in isopropyl acetate (13OmIs) was heated to approximately 6O0C. A solution of DABCO (0.28g, 0.0025mols) in isopropyl acetate (1 OmIs) was added. The mixture was heated to 8O0C and held at this temperature for 360 minutes. The isopropyl acetate was removed by vacuum distillation to a maximum temperature of 8O0C. Toluene (160ml) was added to the distillation residues, maintaining the temperature between 60-700C, followed by water (265mls) which had been heated to 6O0C, again maintaining the temperature between 60-700C. The mixture was stirred for 40 minutes at 8O0C and then settled and the lower aqueous phase separated. The toluene solution (229.8g) EPO contained methyl (E)-2- {2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl} -3- methoxyacrylate (41.2%w/w) 94.2% of theory.

According to the analysis of related databases, 131860-97-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA LIMITED; WO2006/114572; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 131860-97-4, Adding some certain compound to certain chemical reactions, such as: 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate,molecular formula is C15H13ClN2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131860-97-4.

Methyl (£)-2-{2-[6-chloropyiimidin-4-yloxy]phenyl}-3-methoxyacrylate (E) (3g of 95.4% strength) was charged to the reaction tube followed by the solvent (10 ml) then 2- cyanophenol (1.2g), base (1.5 mol equivalents) and the compound being tested as a catalyst (15 mol%). The reaction mixtures were held, with stirring, at 400C for 4hrs, then at 6O0C for 2 hrs. The reaction was monitored for formation of product, throughout the hold period, by Gas Chromatography. Results are recorded as area % levels of methyl (£)-2-{2-[6- chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (II) and methyl (E)-2-{2-[6-(2- cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (I) in the reaction mixture.The following systems were tested:TABLE l The results are shown in Table 2 below:TABLE 2; A stirred solution of (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (80.0g at 98%w/w, 0.24mols) in DMF (80g) was heated to approximately 500C and then potassium carbonate (51.6g at 98%w/w, 0.37mols) was added. The mixture was heated to 6O0C and a solution of 2-cyanophenol in DMF was added (63.9g at 50%w/w, 0.27mols), followed by quinuclidine hydrochloride (1.85g at 97%w/w, 0.012mols). The reaction mixture was heated to 8O0C (exotherm took the temperature to 910C) and held for 20 minutes when analysis indicated that the reaction was complete. The DMF was distilled off under vacuum to a final temperature of 1000C and then toluene (134.8g) was charged, followed by hot water (259.4g), maintaining the temperature of the mixture above 700C. The mixture was stirred at 800C for 30 minutes, settled and then the aqueous phase separated. The toluene phase (233.Og) contained methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidm-4-yloxy]phenyl}-3- methoxyacrylate (41.4%w/w) 98.1 % of theory.; stirred solution of (JS)-2-{2-[6-chloropyrimidiri-4-yloxy]phenyl}-3-methoxyacrylate (80.0g at 98%w/w, 0.24mols) in DMF (80g) was heated to approximately 500C and then potassium carbonate (51.6g at 98%w/w, 0.37mols) was added. The mixture was heated to 600C and quinuclidine hydrochloride (1.85g at 97%w/w, 0.012mols) was charged. The mixture was held at 600C for 10 minutes before adding a solution of 2-cyanophenol in DMF (63.9g at 50%w/w, 0.27mols). The mixture was heated to 80C (exotherm took the temperature to 850C) and held for 90 minutes when analysis indicated that the reaction was complete. The DMF was distilled off under vacuum to a final temperature of 100C and then toluene (134.8g) was charged, followed by hot water (259.4g), maintaining the temperature. of the mixture above 70C. The mixture was stirred at 8O0C for 30 minutes, settled and then the aqueous phase separated. The toluene phase (230.6g) contained methyl (E)-2-{2-[6-(2- cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (35.8%w/w) 84.0% of theory.; A stirred solution of (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (80.0g at 98%w/w, 0.24mols) in DMF (80g) was heated to approximately 5O0C and then potassium carbonate (51.6g at 98%w/w, 0.37mols) was added. The mixture was heated to 60C and a solution of 2-cyanophenol in DMF was added (63.9g at 50%w/w, 0.27mols), followed by quinuclidine hydiOchloride (0.37g at 97%w/w, 0.002mols). The reaction mixture was heated to 8O0C (exotherm took the temperature to 890C) and held for 20 minutes when analysis indicated that the reaction was complete. The DMF was distilled off under vacuum to a final temperature of 1000C and then toluene (134.8g) was charged, followed by hot water (259.4g), maintaining the temperature of the mixture above 700C. The mixture was stirred at 800C for 30 minutes, settled and then the aqueous phase separated. The toluene phase (233.Og) contained methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3- methoxyacrylate (41.3%w/w) 97.9% of theory.; A stirred solution of (E)-I- {2- [6-chloiOpyrimidin-4-yloxy]phenyl} -3 -methoxyacrylate (80.0g at 98%w/w, 0.24mols) in DMF (80g) was heated to approximately 5O0C and then potassium carbonate (51.6g at 98%w/w, 0.37mols) was added. The mixture was heated to 600C and a solution of 2-cyanophenol (32.8g at 97.5%w/w, 0.27mols) in DMF (32g) was added, followed by quinuclidine hydrochloride (0.07g at 97%w/w, 0.0005mols). The reaction mixture was heated to 8O0C (exotherm took the temperature to 85C) and held for 105 minutes when analysis indicated that the reaction was complete. The DMF was distilled off under vacuum to a final temperature of 1000C and then toluene (134.8g) was charged, followed by hot water (259.4g), maintaining the temperature of the mixture above 700C. The mixture was stirred at 8O0C for 30 minutes, settled and then the aqueous phase separated. The toluene phase (229.8g) contained methyl (E)-2-{2-[6-(2-cyanorhohenoxy)pyrimidin-4- yloxy]phenyl}-3-methoxyacrylate (40.5%w/w) 94.7% of theory.; A stirred DMF solution of (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (193.Og at 47.12%w/w, 0.283mols) was heated to …

According to the analysis of related databases, 131860-97-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA LIMITED; WO2008/43977; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. A new synthetic method of this compound is introduced below., Quality Control of (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate

A solution of the above (E) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl] -3-methoxypropenoate in toluene Poured into 500mL three-necked reaction flask, 15.0 g (95%, 0 · 12 mol) of salicylonitrile was added, 10.7 g of sodium carbonate (99% (L) was stirred, heated to 90-95 C for 5 h, and the HPLC analysis showed that (Epsilon) -2- [2- (6-chloropyrimidin-4-yloxy) phenyl] -3 The reaction mixture was cooled to room temperature, filtered and the solid was washed twice with 50 mL of toluene. The filtrate and the washing solution were combined. The toluene was recovered by distillation under reduced pressure, 70 mL of methanol was added, stirred and cooled to 5-KTC , Crystallization, filtration, filter cake with 20mL methanol washing twice, drying, weight 36.7g, content 98.2%, yield 89.4%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 131860-97-4, (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate.

Reference:
Patent; Chongqing Ziguang International Chemical Co., Ltd.; Ding Yongliang; Liu Jia; Zhang Fei; You Huan; Wu Chuanlong; Jin Haiqin; Zheng Daomin; Yao Rujie; (15 pag.)CN104230822; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. A new synthetic method of this compound is introduced below., category: pyrimidines

Methyl (£)-2-{2-[6-chloropyiimidin-4-yloxy]phenyl}-3-methoxyacrylate (E) (3g of 95.4% strength) was charged to the reaction tube followed by the solvent (10 ml) then 2- cyanophenol (1.2g), base (1.5 mol equivalents) and the compound being tested as a catalyst (15 mol%). The reaction mixtures were held, with stirring, at 400C for 4hrs, then at 6O0C for 2 hrs. The reaction was monitored for formation of product, throughout the hold period, by Gas Chromatography. Results are recorded as area % levels of methyl (£)-2-{2-[6- chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (II) and methyl (E)-2-{2-[6-(2- cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (I) in the reaction mixture.The following systems were tested:TABLE l The results are shown in Table 2 below:TABLE 2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 131860-97-4, (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate.

Reference:
Patent; SYNGENTA LIMITED; WO2008/43977; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate

Toluene (40.8g) was stirred and heated to 700C. Methyl (E)-2-{2-[6-chloropyrimidin-4- yloxy]phenyl}-3-methoxyacrylate (24.2g at 98%w/w, 0.074mols), DABCO (0.85g at 98%w/w, 0.007mols) and 2-cyanophenol (9.9g at 97.5%w/w, O.Odeltamols) were added at 10 minute intervals, maintaining the temperature at 7O0C. After a further 10 minutes DBU , (13.8g at 98%w/w, 0.09mols) was added over 5.5 minutes. During the addition the temperature went up to 78C and cooling was applied to maintain 7O0C. The reaction mixture was stirred at 700C for 90 minutes (still 35.8 area% methyl (E)-2-{2-[6- chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate unreacted by GC analysis). The reaction temperature was raised to 800C and stirring continued for another 90 minutes at which time the reaction was still not complete (14.2 area% methyl (E)-2- {2-[6-chloropyrimidin-4- yloxy]phenyl}-3-methoxyacrylate unreacted by GC analysis). The temperature was raised to 1000C and stirring continued for a further 60 minutes to complete the reaction. The reaction mixture was cooled to 700C before hot water (75C) (78.3g) was added. The mixture was stirred for 15 minutes at 70-75C, then settled and the aqueous phase separated. A second water wash (78.3g) was applied in the same way. The toluene phase (66.6g) contained methyl (J£)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (32.8%w/w), 73.3% of theory.

With the rapid development of chemical substances, we look forward to future research findings about 131860-97-4.

Reference:
Patent; SYNGENTA LIMITED; WO2008/43978; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 131860-97-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate, molecular formula is C15H13ClN2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Methyl (£)-2-{2-[6-chloropyiimidin-4-yloxy]phenyl}-3-methoxyacrylate (E) (3g of 95.4% strength) was charged to the reaction tube followed by the solvent (10 ml) then 2- cyanophenol (1.2g), base (1.5 mol equivalents) and the compound being tested as a catalyst (15 mol%). The reaction mixtures were held, with stirring, at 400C for 4hrs, then at 6O0C for 2 hrs. The reaction was monitored for formation of product, throughout the hold period, by Gas Chromatography. Results are recorded as area % levels of methyl (£)-2-{2-[6- chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (II) and methyl (E)-2-{2-[6-(2- cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (I) in the reaction mixture.The following systems were tested:TABLE l The results are shown in Table 2 below:TABLE 2

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 131860-97-4, (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate.

Reference:
Patent; SYNGENTA LIMITED; WO2008/43977; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate

Toluene (40.8g) was stirred and heated to 70C. DABCO (0.85g at 98%w/w, 0.007mols) and 2-cyanophenol (9.9g at 97.5%w/w, 0.08mols) were added at 10 minute intervals. After a further 10 minutes DBU (13.8g at 98%w/w, 0.09mols) was added over 5 minutes (exotherm to 74C). After stirring for a further 10 minutes, methyl (E)-2-{2-[6-chloropyrimidin-4- yloxy]phenyl}-3-methoxyacrylate (24.2g at 98%w/w, 0.074mols) was added and the reaction stirred at 7O0C for 60 minutes (reaction was complete in 30 minutes). Hot water (750C) (78.3g) was added and the mixture stirred for 15 minutes at 70-750C, then settled and the aqueous phase separated. A second water wash (78.3g) was applied in the same way. The toluene phase (73,Ig) contained methyl (i^-2-{2-[6-(2-cyanophenoxy)pyrimidin-4- yloxy]phenyl}-3-methoxyacrylate (38.6%w/w), 94.7% of theory.

With the rapid development of chemical substances, we look forward to future research findings about 131860-97-4.

Reference:
Patent; SYNGENTA LIMITED; WO2008/43978; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 131860-97-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 25 A mixture of 2-cyanophenol (39.7 g), potassium carbonate (62.2 g), polyethylene glycol 400 (60.0 g), (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxypropenoate (98.3 g) and toluene (130 g) was heated at 105 C. for 16 hours. (E)-methyl 2-[2-(6-(2-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate was produced (89.5 area %).

According to the analysis of related databases, 131860-97-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZENECA Limited; US6153750; (2000); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate, molecular formula is C15H13ClN2O4, molecular weight is 320.73, as common compound, the synthetic route is as follows.Formula: C15H13ClN2O4

In this example, a trimethylamine solution in water with the amount of 15 mol % of methyl (E)-2-[2-[6-chloropy-rimidin-4-yloxy]phenyl]-3-methoxyacrylate was used as a catalyst to synthesize azoxystrobin. The specific preparation method was:150 g of toluene, 80.99 g (0.25 mol, 99%) of methyl (E)-2-[2-[6-chloropyrimidin-4-yloxy]phenyl]-3-methoxy-acrylate, 33.09 g (0.275 mol, 99%) of 2-cyanophenol, 27.88 g (0.2 mol, 99%) of potassium carbonate and 8.96 g (0.0375 mol, having a concentration of 33%) of trimethylamine solution in water were added sequentially into a 500 mL reaction flask, stirred, heated to 80 C. and incubated for 4h. When the reaction was completed, 100 g of water was added. Layers were separated to obtain 247.34 g of a toluene solution of azoxystrobin, with a content of 41.21% (w/w), which is 98.94% of the theoretical value.The post-processing was performed as Example 1 toprovide 98.92 g of azoxystrobin with a content of 98.43%and a yield of 96.55%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,131860-97-4, (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate, and friends who are interested can also refer to it.

Reference:
Patent; CAC NANTONG CHEMICAL CO., LTD; Yang, Binglian; Wang, Haishui; Xie, Simian; Tian, Xiaohong; Xu, Jiwang; (8 pag.)US10189793; (2019); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 131860-97-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. A new synthetic method of this compound is introduced below.

Methyl (£)-2-{2-[6-chloropyiimidin-4-yloxy]phenyl}-3-methoxyacrylate (E) (3g of 95.4% strength) was charged to the reaction tube followed by the solvent (10 ml) then 2- cyanophenol (1.2g), base (1.5 mol equivalents) and the compound being tested as a catalyst (15 mol%). The reaction mixtures were held, with stirring, at 400C for 4hrs, then at 6O0C for 2 hrs. The reaction was monitored for formation of product, throughout the hold period, by Gas Chromatography. Results are recorded as area % levels of methyl (£)-2-{2-[6- chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (II) and methyl (E)-2-{2-[6-(2- cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (I) in the reaction mixture.The following systems were tested:TABLE l The results are shown in Table 2 below:TABLE 2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131860-97-4, its application will become more common.

Reference:
Patent; SYNGENTA LIMITED; WO2008/43977; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia