Category: 1337962-47-6

Adding a certain compound to certain chemical reactions, such as: 1337962-47-6, 5-Bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1337962-47-6, blongs to pyrimidines compound. Quality Control of 5-Bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine

To a suspension of 50mg (0.1633 mmol) of 5-bromo-2,6-di(1H-pyrazol-1-yl)- pyrimidin-4-amine (Form F) in lmL ethyl acetate was added 54.5uL HC1 aqueous solution (6M, 0.3266 mmol) dropwise. The mixture was stirred at 50 degree C for 20 hours. The mixture was cooled to room temperature within 2 hours and the stirring was maintained for another 1 hour. The solid was collected with vacuum filtration and dried at r.t overnight. 5-bromo-2,6-di(1H- pyrazol-1-yl)-pyrimidin-4-amine di-hydrochloride hydrate was obtained as a crystalline Form B. The solid was analyzed by XRPD after isolation.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1337962-47-6, its application will become more common.

Reference:
Patent; NOVARTIS AG; CUI, Kai; KONG, Weiyong; CASTRO-PALOMINO LARIA, Julio Cesar; (100 pag.)WO2018/220546; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1337962-47-6, Adding some certain compound to certain chemical reactions, such as: 1337962-47-6, name is 5-Bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine,molecular formula is C10H8BrN7, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1337962-47-6.

A mixture of 8.9 mg (13.1 mu?iotaomicron) of Pd-PEPPSI-IPr-catalyst, 0.1 g (0.33 mmol) of 5-bromo-2,6- di(lH-pyrazol-l-yl)pyrimidin-4-amine (Example 1), 0.1 g (0.65 mmol) of cesium fluoride and activated, crushed 4A molecular sieves (33 mg) in a glass vial was purged with argon and 1 ml of dioxane was added. 0.15 (0.39 mmol) of 2-tributylstannylthiazole was then added and the reaction was stirred at 80C for 24 h. The mixture was filtered throw celite/CsF. The solvent was removed in vacuum. The residue was purified by column chromatography with silica gel and methylene chloride and methanol as eluent to give 47.9 mg (47.2 %) of the desired product.1H-RM (300 MHz, DMSO-d6): delta = 6.57 (dd, 1H), 6.58 (dd, 1H), 7.34 (d, 1H), 7.52 (s, 1H), 7.81 (d, 1H), 7.86 (d, 1H), 7.92 (d, 1H), 8.41 (s, 1H), 8.51 (d, 1H), 8.60 (d, 1H).

According to the analysis of related databases, 1337962-47-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PALOBIOFARMA, S.L.; CAMACHO GOMEZ, Juan Alberto; CASTRO-PALOMINO LARIA, Julio Cesar; WO2011/121418; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia