Category: 135481-57-1

Electric Literature of 135481-57-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.135481-57-1, name is 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione, molecular formula is C14H15N3O2, molecular weight is 257.29, as common compound, the synthetic route is as follows.

To 6-benzyl-5, 6, 7, 8-tetrahydropyrido [4, 3-d] pyrimidine-2, 4(1 H, 3H)-dione (7.2 g, 27.9 mmol), POCI3 (45mL, 6V) was added slowly at 0C and refluxed for 4h. The reactionmixture was evaporated under vacuum. EtOAc (200 mL) was added and the solution was poured over cold 3M NaOH solution. The resulting organic layer was separated and washed with brine (30 mL), dried over anhydrous Na2SO4 and evaporated, affording the title compound. Yield: 79% (6.5 g, brown solid). 1H NMR (400 MHz, DMSO-d6): 6 7.33- 7.32 (m, 5H), 3.77 (s, 2H), 3.56 (s, 2H), 2.94 (t, J = 7.2 Hz, 2H), 2.80 (t, J = 6.8 Hz, 2H).LCMS: (Method A) 296.3 (M +2), Rt. 2.50mm, 97.94% (Max).

The chemical industry reduces the impact on the environment during synthesis 135481-57-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut, Gajendra; (280 pag.)WO2017/144633; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

135481-57-1, Adding a certain compound to certain chemical reactions, such as: 135481-57-1, 6-Benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 135481-57-1, blongs to pyrimidines compound.

6-Benzyl-5,6,7,8-tetrahydropyrido-[4,3-d]pyrimidine-2,4 (1H, 3H) -dione (30.0 g, 0.116 mol) prepared according to Process Step 1 was mixed with phosphorus oxychloride (300 mL), followed by stirring with heating for five hours. After checking the completion of the reaction by thin layer chromatography, excess phosphorus oxychloride was distilled off under reduced pressure. The residue was mixed with isopropyl alcohol (300 mL) for crystallization. The suspension containing the precipitated crystals was stirred under reflux for one hour and was further stirred at room temperature for one hour. The precipitated crystals were collected by filtration, were dried under reduced pressure and thereby yielded 6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimid ine hydrochloride (33 g, in a yield of 85%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,135481-57-1, its application will become more common.

Reference:
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1552842; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia