Category: 137281-08-4

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 137281-08-4, name is N-(4-Oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide, molecular formula is C11H14N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 137281-08-4

N-Methyl benzylamine (3.63 g, 30 mmol) and paraformaldehyde(1.05 g, 35 mmol) were added to water (20 mL). To this solution, aceticacid (20 mL) was added dropwise. The mixture was stirred at 80 C for3 h. Compound 21 (2.34 g, 10 mmol) and KOAc (2.94 g, 30 mmol) wereadded and the stirring was continued at 80 C overnight. The solventwas removed by a rotary evaporator and acetone (40 mL) was added.The suspension was filtered and the filtrate was concentrated into asemisolid residue. This residue was purified by a silica column, whichwas flushed with CHCl3 and MeOH, to provide 2.86 g of a white solid,22, in 78% yield. mp: 181.1-182.5 C; TLC Rf 0.37 (CHCl3: MeOH,20:1); 1H NMR (DMSO-d6) delta 1.24 (s, 9H, Piv), 2.09 (s, 3H, NCH3), 3.48(s, 2H, NCH2), 3.58 (s, 2H, NCH2), 6.31 (s, 1H, 5-H), 7.32 (m, 5H, Ph),10.85 (br, 1H, exch, PivNH), 11.55 (br, 1H, exch, NH), 11.95 (br, 1H,exch, NH); Anal. calcd. for (C20H25N5O2·0.5H2O) C, H, N; UPLCMS> 95%; m/z [M-MePhNH]+, calcd 247.12, found 247.25.

With the rapid development of chemical substances, we look forward to future research findings about 137281-08-4.

Reference:
Article; Xiang, Weiguo; Dekhne, Aamod; Doshi, Arpit; O’Connor, Carrie; Hou, Zhanjun; Matherly, Larry H.; Gangjee, Aleem; Bioorganic and Medicinal Chemistry; vol. 27; 23; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 137281-08-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 137281-08-4, name is N-(4-Oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 7-Iodo-N2-pivaloyl-7-deazaguanine 1a (0.0363 g, 0.101 mmol) and DMAP (0.0272 g, 0.223mmol) were dried by repeated co-evaporation with dry pyridine and dry toluene, and dissolved in dry DMF (0.50mL) under argon. DPC-Cl (0.0263 g, 0.114 mmol) was added, and the mixture was stirred for 24 h at 80 C. Themixture was then cooled to rt, poured into a saturated aqueous solution of NaHCO3 (15 mL), and extracted with CH2Cl2 (3 ¡Á 10 mL). The organic layers were combined, dried over Na2SO4, filtered, and concentrated underreduced pressure. The residue was then purified by column chromatography on silica gel (hexane/AcOEt = 2:1,v/v) to afford 2a (0.0432 g, 0.0777 mmol, 78%) as a pale yellow solid.

According to the analysis of related databases, 137281-08-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Oka, Natsuhisa; Nakano, Koki; Fukuta, Akane; Ando, Kaori; Tetrahedron Letters; vol. 61; 28; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia