Category: 138274-14-3

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine, molecular formula is C11H9ClN2O, molecular weight is 220.66, as common compound, the synthetic route is as follows.HPLC of Formula: C11H9ClN2O

To a 50 mL single-mouth bottle was added 5-benzyloxy-2-chloro-pyrimidine 34b (0.21 g, 0.95 mmol), morpholine (1.0 mL, 11 mmol), water (1 mL) and potassium carbonate (0.27 g, 1.9 mmol) The resulting reaction solution was stirred at 100 C for 19 hours.After the reaction solution was cooled to room temperature, the reaction solution was adjusted to pH = 3 with hydrochloric acid (1 mol/L).The mixture was extracted with EtOAc (EtOAc) (EtOAc)The title compound 46a (0.25 g, yield 96%) obtained as white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,138274-14-3, 5-(Benzyloxy)-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Gu Zheng; Li Jianhao; Li Zheng; Wang Weihua; Tan Haoxiong; Wang Xuli; Cui Yunzeng; Xie Zeqiang; Zhang Yingjun; (101 pag.)CN109251166; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 138274-14-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine, molecular formula is C11H9ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 100 mL two-necked vial, 5-benzyloxy-2-chloropyrimidine 34b (0.50 g, 2.3 mmol), thiophene-3-boronic acid(0.44 g, 3.4 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (0.17 g, 0.23 mmol).After the addition, the reaction system was replaced three times with nitrogen. Toluene (20 mL), ethanol (10 mL) and aqueous sodium carbonate (5.2 mL, 10 mmol, 2 mol/L) were added under nitrogen. The reaction solution was then warmed to 80 C for 2 hours.The heating was stopped, and after the reaction solution was cooled to room temperature, the diatomaceous earth was suction filtered, and the filtrate was washed with water (10 mL) and saturated sodium chloride solution (10 mL).Dry over anhydrous sodium sulfate, concentrate by suction filtration, and the residue obtained was purified by silica gel column chromatography[Petroleum ether / ethyl acetate (v / v) = 10/1] purified,The title compound 42a (0.50 g, yield 82%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 138274-14-3, 5-(Benzyloxy)-2-chloropyrimidine.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Gu Zheng; Li Jianhao; Li Zheng; Wang Weihua; Tan Haoxiong; Wang Xuli; Cui Yunzeng; Xie Zeqiang; Zhang Yingjun; (101 pag.)CN109251166; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 138274-14-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine, molecular formula is C11H9ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 5-benzyloxy-2-chloro-pyrimidine 34b (0.20 g, 0.91 mmol) of N-methylpyrrolidone (5 mL)Potassium fluoride (0.17 g, 2.9 mmol) was added to the solution.Thiomorpholine dioxide (0.13 g, 0.91 mmol). After the addition, the reaction solution was heated to 140 C for 23 hours.The heating was stopped, and after the reaction solution was cooled to room temperature, dichloromethane (30 mL) and water (10 mL) were added and stirred for 10 minutes.The lower organic phase was separated, the aqueous phase was extracted with dichloromethane (10 mL¡Á3), and the combined organic phases were washed with saturated sodium chloride solution (10 mL).Dry over anhydrous sodium sulfate, concentrate by suction filtration, and the residue obtained was purified by silica gel column chromatography[Petroleum ether / ethyl acetate (v / v) = 5 / 1] purified to give the title compound50a (60 mg, 21% yield) as a pale yellow solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 138274-14-3, 5-(Benzyloxy)-2-chloropyrimidine.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Gu Zheng; Li Jianhao; Li Zheng; Wang Weihua; Tan Haoxiong; Wang Xuli; Cui Yunzeng; Xie Zeqiang; Zhang Yingjun; (101 pag.)CN109251166; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 138274-14-3

Sodium hydride (400 mg, 8.33 mmol) was suspended in toluene (10 mL), ethyl 2-hydroxyacetate (0.70 mL,7.40 mmol) was added and the mixture was stirred at room temperature for 30 min. To the reaction mixture was added(M-30) (1.00 g, 4.53 mmol), and the mixture was stirred at 60C for 18 hr. The reaction mixture was allowed to cool,saturated ammonium chloride solution was added and the mixture was extracted with ethyl acetate. The organic layerwas dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residuewas purified by silica gel column chromatography (n-hexane:ethyl acetate) to give compound (M-31) (yield 650 mg,50%) as a colorless oil

With the rapid development of chemical substances, we look forward to future research findings about 138274-14-3.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; WATANABE, Atsushi; SATO, Yuuki; OGURA, Keiji; TATSUMI, Yoshiyuki; (331 pag.)EP3351533; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 138274-14-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine, molecular formula is C11H9ClN2O, molecular weight is 220.66, as common compound, the synthetic route is as follows.

Step 1 In a microwave vial, cis-7-mcthyl-8-((3,4,5-trifluorophcnyl)carbamoyl)-2,3,3a,4,10,10a-hexahydro-lH,7H-dipyrrolo[3,4-b:3′,4′-f][l,4,5]oxathiazocin-2-ium 5,5-dioxide iodide (E11) (20 mg, 0.036 mmol) and 5-(benzyloxy)-2-chloropyrimidine (l5.8 mg, 0.072 mmol) were suspended in 1 -Butanol (0.3mL), dry DIPEA (0.020 mL, 0.115 mmol) was added and mixture heated at l55C under MW for 2 h. The reaction mixture was evaporated under reduced pressure to afford a dark brown solid. The residue was purified by preparative HPLC (H20, CH3CN 0.1% TFA) to afford, after lyophilization 2-(5-(benzyloxy)pyrimidin-2-yl)-7-methyl-N-(3,4,5-trifluorophenyl)-2,3,3a,4,10,10a-hexahydro-lH,7H-dipyrrolo[3,4-b:3′,4′-f][l,4,5]oxathiazocine-8-carboxamide 5,5-dioxide (lOmg, 0.016 mmol, yield= 45%).

Statistics shows that 138274-14-3 is playing an increasingly important role. we look forward to future research findings about 5-(Benzyloxy)-2-chloropyrimidine.

Reference:
Patent; OSPEDALE SAN RAFFAELE S.R.L.; IRBM S.P.A.; PROMIDIS S.R.L.; ISTITUTO NAZIONALE DI GENETICA MOLECOLARE – INGM; DE FRANCESCO, Raffaele; DONNICI, Lorena; GUIDOTTI, Luca; IANNACONE, Matteo; DI FABIO, Romano; SUMMA, Vincenzo; PRANDI, Adolfo; RANDAZZO, Pietro; GORNATI, Davide; GRILLO, Alessandro; FERRANTE, Luca; BENCHEVA, Leda Ivanova; DE MATTEO, Marilenia; FERRARA, Marco; (238 pag.)WO2020/30781; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia