Category: 14001-60-6

《Study on the preparation of heteroaryl substituted enamines. A simple synthesis of heteroaryl substituted acetaldoximes from enamines》 was written by Copar, Anton; Stanovnik, Branko; Tisler, Miha. Safety of 2-Methoxy-4-methylpyrimidine And the article was included in Journal of Heterocyclic Chemistry on April 30 ,1996. The article conveys some information:

A comparative study of the reactivity of Me groups towards N,N-dimethylformamide di-Me acetal and tert-butoxybis(dimethylamino)methane was carried out on Me substituted six-membered nitrogen containing heterocycles to give enamines, which were easily transformed to oximes by treating with hydroxylamine hydrochloride in methanol. Most of them were isolated as (E,Z)-oximes of heteroarylacetaldehyde, but 5-(1,2,4-triazinyl) substituted derivatives were isolated as (E,Z)-oximes of 2,5-dihydro-1,2,4-triazin-(Z)-5-ylideneacetaldehyde. Oximes were finally transformed to the corresponding acetontriles and 3-(dimethylamino)acrylonitriles. In the experimental materials used by the author, we found 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Safety of 2-Methoxy-4-methylpyrimidine)

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Safety of 2-Methoxy-4-methylpyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Pyrimidine reactions. XVI. Thermal rearrangement of substituted 2- and 4-alkoxyprimidines》 was published in Australian Journal of Chemistry in 1968. These research results belong to Brown, Desmond J.; Lee, Tzoong-Chyh. Category: pyrimidines The article mentions the following:

Thermal rearrangement of methyl, bromo, and nitro derivatives of 2- and 4- alkoxypyrimidines produced their N-alkyl isomers, identified by proton magnetic resonance spectral comparison with synthetic specimens of unambiguous or proven structure. The rates for such isomerizations were measured by changes in uv spectra. The C-methyl derivatives rearranged more slowly than the parent alkoxypyrimidines, but the bromo, and especially the nitro derivatives did so much more quickly. Among the derivatives of each methoxypyrimidine, the rate of rearrangement increased as the basic pKa value fell and as the methoxyl protons moved downfield, thus affording a qual. correlation with properties reflecting the electronic effect of each substituent. 32 references. The experimental process involved the reaction of 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6Category: pyrimidines)

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Pyrimidine reactions. XIV. The butylaminolysis of substituted methoxy- and methylthiopyrimidines》 was published in Australian Journal of Chemistry in 1966. These research results belong to Brown, Desmond J.; Foster, Roy V.. COA of Formula: C6H8N2O The article mentions the following:

cf. CA 65, 15374e Aminolyses of 2- and 4-methoxy (or methylthio) pyrimidines bearing C-methyl, CC’-dimethyl, 5-bromo, or 5-intro substituents have proved of value, in the absence of added solvent, for preparing the corresponding n- and tert-butylamino-pyrimidines. When these displacements are followed spectro-metrically, the apparent 1st-order rate constants indicate mild deactivation by addnl. methyl substituents, moderate activation by a bromo substituent, and profound activation by a nitro substituent. Ionization constants and uv spectra of relevant pyrimidines are recorded. 31 references. In addition to this study using 2-Methoxy-4-methylpyrimidine, there are many other studies that have used 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6COA of Formula: C6H8N2O) was used in this study.

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.COA of Formula: C6H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sakamoto, Takao; Ono, Takayasu; Sakasai, Takeji; Yamanaka, Hiroshi published an article on January 31 ,1980. The article was titled 《Studies on pyrimidine derivatives. XV. Homolytic acylation and amidation of simply substituted pyrimidines》, and you may find the article in Chemical & Pharmaceutical Bulletin.COA of Formula: C6H8N2O The information in the text is summarized as follows:

The reaction of 2,6-disubstituted pyrimidines with acyl radicals generated either from pyruvic acid-AgNO3-(NH4)2S2O8 or from aldehyde-FeSO4-Me3COOH in aqueous H2SO4, gave the corresponding 2,6-disubstituted 4-acylpyrimidines. 4,6-Disubstituted pyrimidines gave 2-acetyl- and 2,5-diacetyl-4,6-disubstituted pyrimidines under the same conditions. Homolytic amidation of pyrimidines in which the 2- or 4-positions are free yielded pyrimidine-2- or -4-carboxamides. The experimental process involved the reaction of 2-Methoxy-4-methylpyrimidine(cas: 14001-60-6COA of Formula: C6H8N2O)

2-Methoxy-4-methylpyrimidine(cas: 14001-60-6) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.COA of Formula: C6H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia