Category: 14001-66-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14001-66-2, name is 5-Bromo-2-methoxypyrimidine, molecular formula is C5H5BrN2O, molecular weight is 189.01, as common compound, the synthetic route is as follows.SDS of cas: 14001-66-2

General procedure: To a well stirred solution of substituted internal alkenyltrifluoroborate and the aryl/heteroarylbromides, Cs2CO3 in toluene/H2O (10:1) was added Pd(PPh3)4 and heated to reflux. After 16 h, the reaction was cooled to room temperature and diluted with water. The reaction mixture was extracted with ethyl ether (3x mL). The organic layer was washed with 2N HCl. The aqueous layer was washed with ether and then neutralized with 2N NaOH and extracted with ethyl ether. The organic layer was dried (Na2SO4). The solvent was removed in vacuo and this usually gave clean product. If necessary the crude material was further purified by silica gel column chromatography (elution with EtOAc/MeOH 19:1): The products were usually obtained as a clear pale yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14001-66-2, 5-Bromo-2-methoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Math, Shivanand K.; Mokri, Homayoun H.; Lamunyon, James B.; Cefalo, Dustin R.; Testa, Charles A.; Tetrahedron Letters; vol. 53; 23; (2012); p. 2847 – 2849;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 14001-66-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14001-66-2, name is 5-Bromo-2-methoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Step 4 A mixture of 5-bromo-2-methoxy-pyrimidine (0.218 mmol), X-Phos (28.4 mg, 0.060 mmol), Pd2(dba)3 (18.2 mg, 0.020 mmol) and Cs2C03 (129 mg, 0.397 mmol) was flushed with argon before the addition of a solution of (tetrahydro-pyran-4-yl)-[(S)-3-(5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yloxy)-pyrrolidin-1 -yl]-methanone in dioxane (2 mL). The reaction mixture was heated at 120C for 1 h in a sealed vial, cooled down to rt and filtered over Hyflo, The recovered organic phase was washed with NaHC03 and brine, dried over Na2S04, filtered and concentrated. Purification by preparative reverse phase Gilson HPLC and neutralization of the combined fractions by passing through a SCX-2 cartridge (The cartridge was washed with acetonitrile, CH2CI2 and MeOH, then a solution of NH3 in MeOH 3.5 N was used to released the expected product) gave {(S)-3-[6-(2-methoxy-pyrimidin-5-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yloxy]-pyrrolidin-1 -yl}-(tetrahydro-pyran-4-yl)-methanone (18.7 mg, 21 % yield) 1 H NMR (400 MHz, CDCI3-d, 298K) delta ppm 1.62-1.70 (m, 2H) 1.87-2.01 (m, 2H) 2.20-2.41 (m, 2H) 2.49-2.71 (m, 1 H) 3.07-3.19 (m, 2H) 3.37-4.19 (m, 16H) 5.76 (m, 1 H) 8.32 (s, 2H) 8.65-8.67 (m, 1 H). LCMS: [M+H]+= 441.2, Rt(1 )= 1.12 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14001-66-2, 5-Bromo-2-methoxypyrimidine.

Reference:
Patent; NOVARTIS AG; COOKE, Nigel Graham; FERNANDES GOMES DOS SANTOS, Paulo Antonio; FURET, Pascal; HEBACH, Christina; HOeGENAUER, Klemens; HOLLINGWORTH, Gregory; KALIS, Christoph; LEWIS, Ian; SMITH, Alexander Baxter; SOLDERMANN, Nicolas; STAUFFER, Frederic; STRANG, Ross; STOWASSER, Frank; TUFILLI, Nicola; VON MATT, Anette; WOLF, Romain; ZECRI, Frederic; WO2013/88404; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia