Category: 14048-15-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14048-15-8, name is 2,4-Dimethoxypyrimidin-5-amine, the common compound, a new synthetic route is introduced below. name: 2,4-Dimethoxypyrimidin-5-amine

2,4-Dimethoxypyrimidin-5-amine (0.1 g) was dissolved in dry dichloromethane (5 mL)and pyridine (1 mL) and to this was added /’so-butylchloroformate (0.11 mL). Theresulting mixture was stirred at room temperature for 1 hour and was then poured into INhydrochloric acid and extracted into dichloromethane (2 x lOmL), dried (MgSO4), filteredand concentrated. The residue was dissolved in dry 1,2-dimethoxyethane (5 mL) andsodium hydride (60%, 0.032g) was added, followed by 2,3-dichlorobenzenesulphonylchloride (0.196 g). The reaction was stirred for 1 hour, poured into water and extractedinto ethyl acetate (2 x lOmL) and concentrated. The residue was dissolved in methanol (5mL) and IN sodium hydroxide (5 mL) added. The mixture was heated to reflux for 1hour, cooled and concentrated to 5 mL, acidified by the addition of 2N hydrochloric acidand extracted into ethyl acetate, dried (MgSO4), filtered and concentrated. The residue waspurified by chromatography on silica gel eluting with ethyl acetate /wo-hexanes (1/2) toafford the titled compound as a solid

The synthetic route of 14048-15-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2004/108690; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 14048-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14048-15-8, name is 2,4-Dimethoxypyrimidin-5-amine, molecular formula is C6H9N3O2, molecular weight is 155.16, as common compound, the synthetic route is as follows.

General Procedure for Synthesis; General procedure for 4-Aza-2,3-didehydropodophyllotoxin Sythesis (1). A mixture of substituted heteroaromatic amines (1 eq ), tetronic acid (1 eq), and a corresponding substituted aromatic aldehydes (1 eq) in EtOH (4 mL) was refluxed at temperature 78 oC for 1 h. The reaction mixture was allowed to cool to room temperature 25 oC. and the precipitated product was collected by vacuum filtration and washed with EtOH (3 mL) at room temperature 25 oC and then recrystallized with ethanol (15 mL and 78 oC) to give pure compounds in 90 – 98 % yield in all case.Example 12,4-dimethoxy-5-(3,4,5-trimethoxyphenyl)-5,6,8,9tetrahydrofuro[3′,4′:5,6]pyrido[2,3-iflpyrimidin-6-one (4a). This compound was prepared by method described above employing 3,4,5-trimethoxybenzaldehyde (200 mg, 1.020 mmol), tetronic acid (102 mg, 1.020 mmol) and 2,4-dimethoxypyrimidine-5-amine (158 mg, 1.020 mmol) to affords 4a, 390 mg in 92% yield. Mp: 299-300 C, NMR (200 MHz, DMSO-d6): (53.61 (s, 3H), 3.70 (s, 6H), 3.81 (s, 3H), 3.85 (s, 3H), 4.79-5.02 (m, 3H), 6.43 (s, 2H), 10.61 (s,lH); 13C NMR (75 MHz, DMSO-d6): £34.3, 53.8, 54.3, 55.7, 59.7, 65.2, 93.8, 99.6, 104.7, 136.1, 139.9, 152.4, 156.8, 163.2, 168.8, 171.1; MS (ESI): 416 [M++H]; HRMS (ESI) calcd for C20H22N3O7 ([M+Na]+) 416.1457; found: 416.1447.

Statistics shows that 14048-15-8 is playing an increasingly important role. we look forward to future research findings about 2,4-Dimethoxypyrimidin-5-amine.

Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; AHMED, Kamal; PAIDAKULA, Suresh; BANALA, Ashwini, Kumar; ADLA, Mallareddy; PAPAGARI, Venkat, Reddy; JAKI, Rasheed, Tamboli; WO2012/76942; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14048-15-8, name is 2,4-Dimethoxypyrimidin-5-amine, molecular formula is C6H9N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2,4-Dimethoxypyrimidin-5-amine

In a 250 mL round-bottomed flask equipped with magnetic stirring bar, compounds C-4A (11.6 g, 47 mmol, 1 eq), C-7A (8.7 g, 56 mmol, 1.2 eq) and C-6F (10 g, 47 mmol, 1 eq) were suspended in 75 mL of AcOH, and the flask was tightly closed with plastic stopper. The mixture was heated up to 70 C and stirred at this temperature for 24 h. After that time UPLCMS analysis showed 47 % of the expected product. The reaction mixture was evaporated to dryness. The solid residue was preadsorbed onto silicagel and purified using flash chromatography (20 % to 50 % of AcOEt in n-hexane). All fractions which contained the product were evaporated to dryness to furnish 6.6 g of the desired product C-8.C10, with 83 % purity according to UPLCMS analysis. Yield: 32 %.

With the rapid development of chemical substances, we look forward to future research findings about 14048-15-8.

Reference:
Patent; Adamed sp. z o.o.; FEDER, Marcin; MAZUR, Maria; KALINOWSKA, Iwona; JASZCZEWSKA, Joanna; LEWANDOWSKI, Wojciech; WITKOWSKI, Jakub; JELEN, Sabina; WOS-LATOSI, Katarzyna; (56 pag.)EP3511334; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 14048-15-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14048-15-8, name is 2,4-Dimethoxypyrimidin-5-amine. A new synthetic method of this compound is introduced below.

To a 250 mL sealed tube equipped with magnetic stirring bar, compounds C-4A (12.48 g, 50 mmol, 1 eq), C-7A (7.76 g, 50 mmol, 1 eq) and C-6E (9.06 g, 50 mmol, 1 eq) were added followed by AcOH (100 mL), and the tube was tightly closed with plastic stopper. The mixture was heated up to 80 C (temperature of the heating bath) and stirred at this temperature overnight. After that time UPLCMS analysis showed almost full consumption of starting materials (which equals to 40 % of a product peak area). The reaction mixture was cooled to room temperature and AcOH was evaporated to dryness. The residue was preadsorbed onto silicagel and purified by chromatography (50 % of AcOEt/n-hexane). After removing of solvents product C-8.C7 was obtained as a dark brown solid/foam (7.63 g, 24.9 % yield, 84 % of purity according to UPLCMS analysis.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14048-15-8, its application will become more common.

Reference:
Patent; Adamed sp. z o.o.; FEDER, Marcin; MAZUR, Maria; KALINOWSKA, Iwona; JASZCZEWSKA, Joanna; LEWANDOWSKI, Wojciech; WITKOWSKI, Jakub; JELEN, Sabina; WOS-LATOSI, Katarzyna; (56 pag.)EP3511334; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 14048-15-8 ,Some common heterocyclic compound, 14048-15-8, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2,6-Di-tert-butyl-4-[(2,4-dimethoxypyrimidin-5-yl)amino]phenol was synthesized using the same method as described for 4-[(5-bromo-3-methoxypyrazin-2-yl)amino]-2,6-di-tert- butylphenol in Example 2. 387 mg (2.9 mmol) of A1C13, 0.55 ml of pyridine, 20 ml of 1,2- dichloroethane, 255 mg (1.16 mmol) of 2,6-di-tert-butyl-l,4-benzoquinone, and 180 mg (1.16 mmol) of 2,4-dimethoxypyrimidin-5-amine was used. Reaction time in the imine formation stage was 17 h.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14048-15-8, 2,4-Dimethoxypyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MEDEIA THERAPEUTICS LTD; GOLDSTEINS, Gundars; KOISTINAHO, Jari; KOISTINAHO, Milla; RATILAINEN, Jari; PYSTYNEN, Jarmo; WO2014/68171; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 14048-15-8 , The common heterocyclic compound, 14048-15-8, name is 2,4-Dimethoxypyrimidin-5-amine, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Example 95 5-Isothiocyanato-2,4-dimethoxypyrimidine To a solution of 2,4-dimethoxypyrimidin-5-amine (prepared by the method described in U.S. Pat. No. 6,342,503B1) (4.68 g, 30.0 mmol) in tetrahydrofuran (60 mL) was added 1,1-thiocarbonyldiimidazole (6.41 g, 36.0 mmol) portionwise at 0 C. The mixture was warmed to room temperature and stirred for 20 hr. The mixture was concentrated in vacuo to give a residue which was passed through a pad of silica gel eluding with n-hexane/ethyl acetate. The filtrate was concentrated in vacuo to give the title compound (5.0 g, 84%) as a colorless solid. 1H NMR (CDCl3) delta 3.99 (s, 3H), 4.09 (s, 3H), 8.06 (s, 1H). MS Calcd.: 197; Found: 198 (M+H).

The synthetic route of 14048-15-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/186879; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

14048-15-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14048-15-8, name is 2,4-Dimethoxypyrimidin-5-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a 250 mL sealed tube equipped with magnetic stirring bar, compounds C-4A (12.48 g, 50 mmol, 1 eq), C-7A (7.76 g, 50 mmol, 1 eq) and C-6E (9.06 g, 50 mmol, 1 eq) were added followed by AcOH (100 mL), and the tube was tightly closed with plastic stopper. The mixture was heated up to 80 C (temperature of the heating bath) and stirred at this temperature overnight. After that time UPLCMS analysis showed almost full consumption of starting materials (which equals to 40 % of a product peak area). The reaction mixture was cooled to room temperature and AcOH was evaporated to dryness. The residue was preadsorbed onto silicagel and purified by chromatography (50 % of AcOEt/n-hexane). After removing of solvents product C-8.C7 was obtained as a dark brown solid/foam (7.63 g, 24.9 % yield, 84 % of purity according to UPLCMS analysis.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14048-15-8, 2,4-Dimethoxypyrimidin-5-amine.

Reference:
Patent; Adamed sp. z o.o.; FEDER, Marcin; MAZUR, Maria; KALINOWSKA, Iwona; JASZCZEWSKA, Joanna; LEWANDOWSKI, Wojciech; WITKOWSKI, Jakub; JELEN, Sabina; WOS-LATOSI, Katarzyna; (56 pag.)EP3511334; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia